Identification and functional analysis of novel MR co-regulator

• Project/Area Number: 23791051
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: Keio University
• Principal Investigator: YOKOTA Kenichi 慶應義塾大学, 医学部, 助教 (50424156)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: アルドステロン / 転写 / 高血圧 / MR / エピゲノム

Research Abstract

We identified p150 as a novel MR co-regulator. P150 interacts with MR in a ligand dependent manner and acts as a co-repressor. It is possible that p150 plays an important role in the pathophysiology of essential hypertension.

Research Products

• [Journal Article] 副腎不全 (2012)
  • Author(s): 横田健一
  • Journal Title: medicina Volume: 49 Pages: 1588-1592
• [Journal Article] 原発性アルドステロン症の局在診断 (2012)
  • Author(s): 横田健一
  • Journal Title: ホルモンと臨床 Volume: 59 Pages: 52-58
• [Journal Article] Signal-sensing activation of a histone lysine demethylase complex (2011)
  • Author(s): Baba A
  • Journal Title: Nat Cell Biol. Volume: 13 Issue: 6 Pages: 669-76
  • DOI: 10.1038/ncb2228
  • Peer Reviewed
• [Journal Article] Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS1 (2011)
  • Author(s): N.Suda, H.Shibata, et al.
  • Journal Title: Endocrinology Volume: 152 Issue: 6 Pages: 2266-2277
  • DOI: 10.1210/en.2010-1232
  • Peer Reviewed
• [Presentation] 新規MR転写共役因子の探索とその機能解析 (2011)
  • Author(s): 横田健一
  • Organizer: 2011 年日本ステロイドホルモン学会(福岡)にて招待講演
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-26
• [Presentation] 新規MR転写共役因子の探索とその機能解析 (2011)
  • Author(s): 横田健一
  • Organizer: 2011年核内受容体研究会(東京)にて招待講演
  • Place of Presentation: 東京
  • Year and Date: 2011-03-11
• [Presentation] MR結合新規転写共役因子の探索とその機能解析 (2011)
  • Author(s): 横田健一
  • Organizer: 日本ステロイドホルモン学会(招待講演)
  • Place of Presentation: 福岡大学（福岡県）
• [Book] 副腎不全medicina49(9) (2012)
  • Author(s): 横田健一, 柴田洋孝
• [Book] ミネラルコルチコイド受容体の活性化による心血管障害 原発性アルドステロン症診療マニュアル (2011)
  • Author(s): 横田健一, 柴田洋孝, 伊藤裕