Elucidation of the mechanism for hematopoietic stem cell development
| Project/Area Number |
23791078
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Mie University |
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Principal Investigator |
YAMANE Toshiyuki 三重大学, 医学(系)研究科(研究院), 准教授 (30452220)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 造血幹細胞 / 造血発生 / 幹細胞 / 発生 / 細胞分化 |
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| Research Abstract |
Hematopoietic stem cells (HSC) are a subset of cells that are capable of self-renewal and differentiation into all mature blood cell lineages. In this study, we identified the common precursors of primitive erythrocytes and multipotent hematopoietic cells in early mouse development before the emergence of HSC. We compared the gene expression profiles between pre-HSC stage hematopoietic cells and HSC. Though the analysis, we identified genes distinctly expressed between these early progenitors and stem cells, suggesting the involvement of these genes into the stemness of blood cell system.
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Report
(4 results)
Research Products
(31 results)
