Investigation of diagnostic and prognostic markers of severe cutaneous adverse drug reactions

Research Project

Project/Area Number	23791243
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Dermatology
Research Institution	Hokkaido University
Principal Investigator	MURATA Jyunko 北海道大学, 大学院・医学研究科, 非常勤講師 (10598387)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	皮膚炎症 / 再生学 / 重症薬疹 / 中毒性表皮壊死症 / Stevens-Johnson症候群 / 早期診断マーカー / 可溶性FasL / グラニュライシン / 薬剤過敏症症候群
Research Abstract	Severe cutaneous adverse drug reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis) are life-threating diseases. In this project, we investigated to identify diagnostic and prognostic markers using patients’ PBMCs. Patients’ PBMCs were stimulated with causative drugs and mRNA and proteins were collected. These mRNA and proteins profiles were compared to those of non-severe cutaneous adverse drug reactions (maculopapular tyoe). We identified sFasL and granulysin are the markers.