The role of the nucleus accumbens in deficit of decision making: a rodent study with the manipulations on dopamine tone
Project/Area Number |
23791316
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | Kanazawa University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 意思決定 / 習慣形成 / モチベーション / 側坐核 / ドパミントーン / 興奮性シナプス伝達 / 個体差 / ストレス / 中脳辺縁ドパミン系 / 報酬学習 / 急性/慢性ストレス / グルタミン酸 / ドーパミントーン |
Research Abstract |
Our results suggested that a high-dose administration of a dopamine-receptor partial agonist, aripiprazole, which is thought to block dopamine tone in the nucleus accumbens, would be able to normalize the upregulated excitatory synaptic transmission induced by chronic unpredictable stress or chronic administration of an antidepressant, fluoxetine. In addition, we established a new behavioral measure to reflect motivation, which would depend on dopamine tone in the nucleusaccumbens, and flexible decision making, which would depend on glutamate tone. These resultsprovided clues to understand unknown accumbal role and molecular mechanisms in decision makingand its deficits.
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Report
(3 results)
Research Products
(29 results)
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[Presentation] Upregulation of extrasynaptic GABAA receptors in the nucleus accumbens may be responsible for animal model of major depressive disorder2011
Author(s)
Iguchi, Y., Kosugi, S., Hirosawa, T., Minabe, Y., & Toda, S
Organizer
Neuroscience 2011 (SfN's 41th annual meeting)
Place of Presentation
Washington DC, USA
Related Report
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[Presentation] Upregulation of extrasynaptic GABA^ receptors in the rat nucleus accumbens after repeated unpredictable stress: a possible compensatory mechanism against depression2011
Author(s)
Iguchi, Y., Kosugi, S., Hirosawa, T., Minabe, Y., & Toda, S
Organizer
The Anxiety and Depression: 21st Neuropharmacology Conference
Place of Presentation
Falls Church, VA, DC, USA
Related Report
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[Presentation] pregulation of extrasynaptic GABAA receptors and PSD-95 in the nucleus accumbens may be responsible for animal model of major depressive disorder2011
Author(s)
Iguchi, Y., Kosugi, S., Hirosawa, T., Minabe, Y., & Toda, S
Organizer
第32回内藤コンファランス「こころの機能と疾患の分子機構」
Place of Presentation
八ヶ岳ロイヤルホテル, 山梨
Related Report
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[Presentation] Upregulation of extrasynaptic GABAA receptors and PSD-95 in the nucleus accumbens may be responsible for animal model of major depressive disorder2011
Author(s)
Iguchi, Y., Kosugi, S., Hirosawa, T., Minabe, Y., & Toda, S
Organizer
第34回日本神経科学大会
Place of Presentation
パシフィコ横浜, 神奈川
Related Report
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[Presentation] Upregulation of extrasynaptic GABAA receptors in the nucleus accumbens may be responsible for animal model of major depressive disorder.2011
Author(s)
Iguchi, Y., Kosugi, S., Hirosawa, T., Minabe, Y., & Toda, S.
Organizer
Annual meeting of Society for Neuroscience
Place of Presentation
Convention Center, DC, USA
Related Report
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[Presentation] Upregulation of extrasynaptic GABAA receptors in the rat nucleus accumbens after repeated unpredictable stress: a possible compensatory mechanism against depression.
Author(s)
Iguchi, Y., Kosugi, S., Hirosawa, T., Minabe, Y., & Toda, S
Organizer
The Anxiety and Depression: 21st Neuropharmacology Conference
Place of Presentation
Westin, Tysons Corner, VA, USA
Related Report
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