Clinicopathological study of frontotemporal lobar degeneration
Project/Area Number |
23791346
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | Yokohama City University |
Principal Investigator |
KATSUSE Omi 横浜市立大学, 医学部, 講師 (40420674)
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Project Period (FY) |
2011-04-28 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 認知症 / 神経変性疾患 |
Outline of Final Research Achievements |
We reported 3 cases of Nasu-Hakola disease and a case of concurrent Huntington's disease and neurofibromatosis type 1. These cases had clinical presentation like frontotemporal lobar degeneration (FTLD). And, clinical and pathological features of 66 cases with FTLD were studied. Although FTLD is clinicopathological heterogeneous disorders, our results suggest that there pathological subtypes tend to have particular clinical Symptoms. Further,we pathologically studied the localization of fused in sarcoma (FUS) protein which is one of some proteins leading to FTLD. The results revealed that FUS protein is detecyed in the post-synaptic density.
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Report
(5 results)
Research Products
(54 results)
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[Journal Article] An Autopsy case of concurrent Huntington’s disease and neurofibromatosis type 1.2014
Author(s)
Kawakami I, Katsuse O, Aoki N, Togo T, Suzuki K, Isojima D, Kondo D, Iseki E, Kosaka K, Akiyama H, Hirayasu Y
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Journal Title
Psychogeriatrics
Volume: 14
Issue: 1
Pages: 81-86
DOI
Related Report
Peer Reviewed
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[Journal Article] Progressive nonfluent aphasia : A rare clinical subtype of FTLD-TDP in Japan2012
Author(s)
Aoki N, Tsuchiya K, Kobayashi Z, Arai T, Togo T, Miyazaki H, Kondo H, Ishizu H, Uchikado H, Katsuse O, Hirayasu Y, Akiyama H
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Journal Title
Neuropathology
Volume: (in press)
Issue: 3
Pages: 272-9
DOI
Related Report
Peer Reviewed
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[Journal Article] 急性期症状が明らかでなかった間歇型一酸化炭素中毒の1例2012
Author(s)
伊倉 崇浩, 勝瀬 大海, 鎌田 鮎子, 土居 浩, 鶴貝 紗矢子, 千葉 悠平, 岸田 郁子, 浅沼 和哉, 金澤 さやか, 都甲 崇, 平安 良雄
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Journal Title
精神科治療学
Volume: 27
Pages: 1085-1091
Related Report
Peer Reviewed
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[Journal Article] Neuropathological investigation of the hypometabolic regions on positron emission tomography with [18F] fluorodeoxyglucose in patients with dementia with Lewy bodies.2012
Author(s)
Kasanuki K, Iseki E, Fujishiro H, Yamamoto R, Higashi S, Minegishi M, Togo T, Katsuse O, Uchikado H, Furukawa Y, Hino H, Kosaka K, Sato K, Arai H.
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Journal Title
J Neurol Sci
Volume: 314
Pages: 111-119
Related Report
Peer Reviewed
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[Journal Article] Gray matter lesions in Nasu-Hakola disease: A report on three autopsy cases.2011
Author(s)
Aoki N, Tsuchiya K, Togo T, Kobayashi Z, Uchikado H, Katsuse O, Suzuki K, Fujishiro H, Arai T, Iseki E, Anno M, Kosaka K, Akiyama H, Hirayasu Y
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Journal Title
Neuropathology
Volume: 31
Pages: 135-143
Related Report
Peer Reviewed
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[Journal Article] Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies.2011
Author(s)
Higashi S, Moore DJ, Minegishi M, Kasanuki K, Fujishiro H, Kabuta T, Togo T, Katsuse O, Uchikado H, Furukawa Y, Hino H, Kosaka K, Sato K, Arai H, Wada K, Iseki E.
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Journal Title
J Neuropathol Exp Neurol
Volume: 70
Pages: 264-280
Related Report
Peer Reviewed
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[Presentation] レビー小体型認知症剖検脳のMelanin-Concentrating Hormone (MCH)発現に関する神経病理学的検討.2014
Author(s)
近藤大三, 笠貫浩史, 藤城弘樹, 峯岸道子, 佐藤潔, 日野博昭, 勝瀬大海, 小阪憲司, 平安良雄, 新井平伊, 井関栄三.
Organizer
第55回日本神経病理学会
Place of Presentation
学術総合センター(東京)
Year and Date
2014-06-05 – 2014-06-07
Related Report
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[Presentation] Two cases of mild neuropsychiatric systemic lupus erythematosus that responded to immunotherapy and exhibited improvement of brain [18F]-fluoro-d-glucose positron emission tomography.2014
Author(s)
Saito T, Hama M, Chiba Y, Katsuse O, Kamada A, Ikura T, Minegishi K, Ihata A, Takahash Y, Ishigatsubo Y, Hirayasu Y.
Organizer
12th Psychoimmunology Expert Meeting
Place of Presentation
Schloss Reisensburg(Guenzburg, Germany)
Related Report
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[Presentation] 認知症終末期患者のケアに関する家族の満足度についての後方視的調査2013
Author(s)
斎藤知之, 千葉悠平, 勝瀬大海, 玉津彰英, 山本かおり, 都甲崇, 内門大丈, 藤城弘樹, 佐伯彰, 小田原俊成, 平安良雄
Organizer
第109回日本精神神経学会
Place of Presentation
福岡国際会議場(福岡)
Related Report
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