Etiology elucidation of schizophrenia that focus on oligodendrocyte progenitor cells

• Project/Area Number: 23791362
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: TOYOSHIMA Manabu 独立行政法人理化学研究所, 分子精神科学研究チーム, 基礎科学特別研究員 (90582750)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 統合失調症 / NG2(+)細胞 / NG2陽性細胞 / オリゴデンドロサイト / NG2細胞

Research Abstract

We analyzed change of gene expression and cell counts in NG2 (+) cell by using therapeutic drug-treated NG2DsRed mice and schizophrenia-model NG2DsRed mice. We observed that NG2 (+) cell counts and expression of Rbpj gene changed in the lithium-treated NG2DsRed mice. These results suggest that Lithium controls the proliferation and differentiation of NG2 (+) cells via Notch signaling.

Research Products

• [Journal Article] A population-specific uncommon variant in GRIN3A associated with schizophrenia. (2013)
  • Author(s): Takata A, Iwayama Y, Fukuo Y, Ikeda M, Okochi T, Maekawa M, Toyota T, Yamada K, Hattori E, Ohnishi T, Toyoshima M, Ujike H, Inada T, Kunugi H, Ozaki N, Nanko S, Nakamura K, Mori N, Kanba S, Iwata N, Kato T, Yoshikawa T.
  • Journal Title: Biological Psychiatry Volume: 73 Pages: 532-539
  • Peer Reviewed
• [Journal Article] A cis-complex of NB-2/contactin-5 with amyloid precursor-like protein 1 is localized on the presynaptic membrane. (2012)
  • Author(s): Shimoda Y, Koseki F, Itoh M, Toyoshima M, Watanabe K
  • Journal Title: Neurosci Lett. Volume: 510 Pages: 148-153
  • Peer Reviewed
• [Journal Article] Schizophrenia with the 22q11.2 deletion and additional genetic defects: case history. (2011)
  • Author(s): Toyoshima M, Maekawa M, Toyota T, Iwayama Y, Arai M, Ichikawa T, Miyashita M, Arinami T, Itokawa M, Yoshikawa T
  • Journal Title: Br J Psychiatry. Volume: 199 Pages: 245-246
  • Peer Reviewed
• [Journal Article] 現代社会とうつ病 遺伝子発現からみたうつ病の神経科学 (2011)
  • Author(s): 前川素子, 豊島学, 吉川武
  • Journal Title: 最新医学 Volume: 66 Pages: 2400-2405
• [Presentation] 精神疾患治療薬に対するオリゴデンドロサイト前駆細胞の挙動 (2012)
  • Author(s): 前川素子、渡邉 明子、大西 哲生、豊島 学、吉川武男
  • Organizer: 第45回精神神経系薬物治療研究報告会
  • Place of Presentation: 大阪
  • Year and Date: 2012-12-15
• [Presentation] iPS 細胞を用いたカルボニルストレス性統合失調症の病因解析 (2012)
  • Author(s): 豊島学、市川智恵、赤松和土、糸川昌成、岡野栄之、吉川武男
  • Organizer: 日本人類遺伝学会第57回大会
  • Place of Presentation: 東京
• [Presentation] カルボニルストレスが 神経分化・発達に及ぼす影響 (2012)
  • Author(s): 豊島学、市川智恵、赤松和土、糸川昌成、岡野栄之、吉川武男
  • Organizer: 第39回日本脳科学会
  • Place of Presentation: 福岡
• [Presentation] Establishment of human induced pluripotent stem cells from a DiGeorge syndrome patient with schizophrenia (2011)
  • Author(s): Toyosima M, Akamatsu W, Okano H, Yoshikawa T
  • Organizer: The 32nd Naito Conference
  • Place of Presentation: Yamanashi
• [Presentation] 統合失調症特殊例(22q11.2 欠失症候群)のiPS 細胞の樹立 (2011)
  • Author(s): 豊島学、赤松和土、岡野栄之、吉川武男
  • Organizer: 第38回日本脳科学会
  • Place of Presentation: 沖縄
• [Presentation] 精神疾患治療薬に対するオリゴデンドロサイト前駆細胞の挙動
  • Author(s): 前川素子、渡邉 明子、大西 哲生、豊島 学、吉川 武男
  • Organizer: 第45回精神神経系薬物治療研究報告会
  • Place of Presentation: 大阪国際会議場