Development of noninvasive imaging biomarker for early diagnosis and prediction of outcome of intractable diseases of the central nervous system

• Project/Area Number: 23791380
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: THA KHIN KHIN 北海道大学, 医学(系)研究科(研究院), 特任講師 (20451445)
• Research Collaborator: TERAE Satoshi 北海道大学, 大学院医学研究科, 客員教授 (40240634) ; YABE Ichiro 北海道大学, 大学院医学研究科, 准教授 (60372273)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 拡散テンソル / 神経難病 / 頚髄 / 脳 / MRI

Research Abstract

This study evaluated if the major diffusion tensor imaging (DTI) metrics of the brain and the spinal cord can become the quantitative metrics for noninvasive evaluation of intractable diseases of the central nervous system.
Significant alterations in the major DTI metrics were observed in sporadic amyotrophic lateral sclerosis, multiple sclerosis, and neuromyelitis optica spectrum disorders, despite no abnormality on the routine MRI sequences. The abnormalities detected on DTI are thought to reflect axonal loss and/ or demyelination. In sporadic amyotrophic lateral sclerosis, the DTI abnormalities correlated strongly with the scores which determine disease severity or progression. In conclusion, DTI is considered a sensitive technique to detect the microstructural abnormalities of the brain and the spinal cord in the intractable diseases of the central nervous system; and can be used to noninvasively quantify the severity or progression of these diseases.

Research Products

• [Journal Article] Laterality of the corticospinal tract and the influence of handedness : the findings of a DTI study (2013)
  • Author(s): Tha KK, Terae S, Hamaguchi H, Ishizaka K, Popy KA, Hirotani M, Sugimori H, Fujima N, Yoshida A, Minowa K, Suzuki Y, Shirato H.
  • Journal Title: 日本磁気共鳴医学会雑誌 Volume: 33 (1)(現在2件投稿中) Pages: 33-34
  • NAID: 10031163469
• [Journal Article] Laterality of the corticospinal tract and the influence of handedness: the findings of a DTI study. (2013)
  • Author(s): Tha KK, Terae S, Hamaguchi H, Ishizaka K, Popy KA, Hirotani M, Sugimori H, Fujima N, Yoshida A, Minowa K, Suzuki Y, Shirato H.
  • Journal Title: 日本磁気共鳴医学会雑誌 Volume: 33 (1) Pages: 33-34
  • NAID: 10031163469
• [Presentation] 小脳白質 : 解剖と疾患(仮) (2014)
  • Author(s): Tha KK
  • Organizer: 第7回Neuro-imaging Refresher Club
  • Place of Presentation: 東京
  • Year and Date: 2014-11-23
• [Presentation] Regional DTI metrics of the cervical spinal cord in sporadic amyotrophic lateral sclerosis (2014)
  • Author(s): Tha KK, Yabe I, Terae S, Hirotani M, Hamaguchi H, Suzuki Y, Okuaki T, Minowa K, Sasaki H, Shirato H.
  • Organizer: 第73回日本放射線学会
  • Place of Presentation: 横浜
• [Presentation] The effect of respiratory and cardiac gating on the major diffusion imaging metrics (2014)
  • Author(s): Hamaguchi H, Tha KK, Sugimori H, Nakanishi M, Nakagawa S, Fujiwara T, Yoshida H, Takamori S, Shirato H.
  • Organizer: European Congress of Radiology
  • Place of Presentation: Vienna、Austria
• [Presentation] Regional DTI metrics of the cervical spinal cord in sporadic amyotrophic lateral sclerosis (2014)
  • Author(s): Tha KK, Yabe I, Terae S, Hirotani M, Hamaguchi H, Suzuki Y, Okuaki T, Minowa K, Sasaki H, Shirato H
  • Organizer: 第73回日本放射線学会
  • Place of Presentation: Pacifico Yokohama（横浜）
• [Presentation] The effect of respiratory and cardiac gating on the major diffusion imaging metrics (2014)
  • Author(s): Hamaguchi H, Tha KK, Sugimori H, Nakanishi M, Nakagawa S, Fujiwara T, Yoshida H, Takamori S, Shirato H
  • Organizer: European Congress of Radiology
  • Place of Presentation: Austria Center（Vienna, Austria）
• [Presentation] 体内水分子の拡散を非侵襲的に観察するMRI撮像法 : 現状と将来展望 (2013)
  • Author(s): Tha KK
  • Organizer: 第78回未来医療イノベーションセミナー
  • Place of Presentation: 札幌
  • Year and Date: 2013-04-10
• [Presentation] The ascending sensory pathways may not be spared in amyotrophic lateral sclerosis (2013)
  • Author(s): Tha KK, Yabe I, Terae S , Hirotani M, Hamaguchi H, Ishizaka K, Suzuki Y, Okuaki T, Minowa K, Sasaki H, Shirato H.
  • Organizer: The 11^<th> International Symposium for Future Drug Discovery and Medical Care
  • Place of Presentation: 札幌
• [Presentation] Laterality of the corticospinal tract and variation with handedness : a diffusion tensor imaging observation (2013)
  • Author(s): Tha KK, Terae S, Hamaguchi H, Ishizaka K, Hirotani M, Minowa K, Suzuki Y, Shirato H.
  • Organizer: ISMRM 21^<st> Annual Meeting & Exhibition
  • Place of Presentation: Salt Lake City、USA
• [Presentation] Diffusion tensor imaging characteristics of the normal human corticospinal tract (2013)
  • Author(s): Tha KK, Terae S, Hamaguchi H, Ishizaka K, Hirotani M, Okuakai T, Suzuki Y, Minowa K, Shirato H.
  • Organizer: 第42回日本神経放射線学会
  • Place of Presentation: 北九州
• [Presentation] The ascending sensory pathways may not be spared in amyotrophic lateral sclerosis (2013)
  • Author(s): Tha KK, Yabe I, Terae S, Hirotani M, Hamaguchi H, Ishizaka K, Suzuki Y, Okuaki T, Minowa K, Sasaki H, Shirato H
  • Organizer: The 11th International Symposium for Future Drug Discovery and Medical Care
  • Place of Presentation: Science Bldg. No. 5, 2nd Floor, Graduate School of Science, Hokkaido University （札幌）
• [Presentation] Diffusion tensor imaging characteristics of the normal human corticospinal tract (2013)
  • Author(s): Tha KK, Terae S, Hamaguchi H, Ishizaka K, Hirotani M, Okuakai T, Suzuki Y, Minowa K, Shirato H
  • Organizer: 第42回日本神経放射線学会
  • Place of Presentation: 北九州国際会議場（北九州市）
• [Presentation] Laterality of the corticospinal tract and variation with handedness: a diffusion tensor imaging observation (2013)
  • Author(s): Tha KK, Terae S, Hamaguchi H, Ishizaka K, Hirotani M, Minowa K, Suzuki Y, Shirato H
  • Organizer: ISMRM 21st Annual Meeting & Exhibition
  • Place of Presentation: Salt Palace Convention Center（USA）
• [Presentation] Laterality of the corticospinal tract and influence of handedness : a diffusion tensor imaging observation (2012)
  • Author(s): Tha KK, Terae S, Hamguchi H, Ishizaka K, Popy KA, Hirotani M, Minowa K, Suzuki Y, Shirato H.
  • Organizer: The 10^<th> International Symposium for Future Drug Discovery and Medical Care
  • Place of Presentation: 札幌
• [Presentation] Laterality of the corticospinal tract and influence of handedness : a diffusion tensor imaging observation (2012)
  • Author(s): Tha KK, Terae S, Hamaguchi H, Ishizaka K, Popy KA, Hirotani M, Sugimori H, Fujima N, Yoshida A, Minowa K, Suzuki Y, Shirato H.
  • Organizer: 第40回日本磁気共鳴医学会
  • Place of Presentation: 京都
• [Presentation] Laterality of the corticospinal tract and influence of handedness: a diffusion tensor imaging observation (2012)
  • Author(s): Tha KK, Terae S, Hamaguchi H, Ishizaka K, Popy KA, Hirotani M, Sugimori H, Fujima N, Yoshida A, Minowa K, Suzuki Y, Shirato H
  • Organizer: 第40回日本磁気共鳴医学会
  • Place of Presentation: 国立京都国際会館(京都市）
• [Presentation] Laterality of the corticospinal tract and influence of handedness: a diffusion tensor imaging observation (2012)
  • Author(s): Tha KK, Terae S, Hamaguchi H, Ishizaka K, Popy KA, Hirotani M, Minowa K, Suzuki Y, Shirato H
  • Organizer: The 10th International Symposium for Future Drug Discovery and Medical Care
  • Place of Presentation: 北海道大学フラテ会館（札幌市）
• [Presentation] 体内水分子の拡散を非侵襲的に観察するMRI撮像法：現状と将来展望
  • Author(s): タキンキン
  • Organizer: 第78回 未来医療イノベーションセミナー
  • Place of Presentation: 北海道大学大学院医学研究科医学部学友会館「フラテ」1階 大研修室〔札幌）
• [Presentation] 小脳白質ー解剖と疾患（仮）
  • Author(s): タキンキン
  • Organizer: 第7回 Neuro- Imaging Refresher Club
  • Place of Presentation: 東京コンファレンスセンター品川〔東京）
  • Invited
• [Remarks] FA database
  • URL: http://rad.med.hokudai.ac.jp/research2/fa/