Development of new embolic material with high-molecular-weight polysaccharide and investigation for the degree of drug-eluting capability
| Project/Area Number |
23791423
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | インターベンショナルラジオロジー / 塞栓物質 / 血管塞栓術 / インターベンショナルラジオロジー （IVR） |
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| Research Abstract |
The main purpose of the present study was to develop the new embolic material with high-molecular-weight polysaccharide and investigate the ability of this embolic material and the degree of drug-eluting capability. As the embolic material, I have created a spherical material by cross-linking the calcium chloride and sodium alginate.
Optimal preparation for the condition of the calcium alginate beads was ezamined by measuring the physical properties of the spherical material, while changing the concentration of sodium alginate and calcium chloride. Furthermore, epirubicin hydrochloride as an anticancer drug was contained in the calcium alginate beads and its drug eluting ability was investigated. Then, embolic ability of calcium alginate beads for the vessels and organs were also evaluated by animal experiments.
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Report
(4 results)
Research Products
(1 results)
