Homeobox B9 induces EMT-associated radioresistance by accelerating DNA damage responses
| Project/Area Number |
23791499
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 乳癌 / HOXB9 / TGFβ / 放射線 / ATM / EMT / 放射線耐性 |
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| Research Abstract |
We show that HOXB9 confers resistance to ionizing radiation by promoting DNA damage response. In non-irradiated cells, HOXB9 induces spontaneous DNA damage, phosphorylated histone 2AX and p53 binding protein 1 foci, and increases baseline ataxia telangiec
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Direct inhibition of the transforming growth factor-β pathway by protein-bound polysaccharide through inactivation of Smad2 signaling2012
Author(s)
Ono Y, Hayashida T, Konagai A, Okazaki H, Miyao K, Kawachi S, Tanabe M, Shinoda M, Jinno H, Hasegawa H, Kitajima M, Kitagawa Y.
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Journal Title
Cancer Sci.
Volume: 103(2)
Issue: 2
Pages: 317-24
DOI
Related Report
Peer Reviewed
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[Journal Article] Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses2012
Author(s)
Chiba N, Comaills V, Shiotani B, Takahashi F, Shimada T, Tajima K, Winokur D, Hayashida T, Willers H, Brachtel E, Vivanco MD, Haber DA, Zou L, Maheswaran S
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Journal Title
Proc Natl Acad Sci U S A
Volume: 109
Pages: 2760-2765
Related Report
Peer Reviewed
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