mechanism of bile duct carcinogenesis using rat model of pancreaticobiliary maljunction
| Project/Area Number |
23791537
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2012 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 膵 / 胆管合流異常 / adenoma-carcinoma sequence / 胆道癌 / 膵・胆管合流異常症 / 膵・胆管合流異常 / Dibutyltin chloride |
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| Research Abstract |
In pancreaticobiliary maljunction, reflux of pancreatic juice causes many conditions including inflammation, and may be relate to carcinogenesis. However, mechanism is not well known. This time, we administered DBTC torats and made the model of pancreaticobiliary maljunction. Single dose of 8mg/kg DBTC caused biliary stasis and papillary growth of epithelium, and we confirmed high expression of Ki-67, COX2 and HDAC by immunohistochemistry. However, papillary growth was recovered 4 weeks after administration. As Rats died by frequent dose of DBTC and we could not observe in long time, we try to make mouse model of pancreaticobiliary maljunction by surgical technique.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Surgical results of pancreatoduodenectomy in elderly patients2012
Author(s)
Yamada S, Shimada M, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Mori H, Kanamoto M, Hanaoka J, Iwahashi S, Saitoh Y.
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Journal Title
Surg Today
Volume: 42(9)
Pages: 857-862
NAID
Related Report
Peer Reviewed
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