Study of postoperative portal venous thrombosis after splenectomy in cirrhotic patients and its therapeutic implication
| Project/Area Number |
23791546
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
KINJYO Nao 九州大学, 大学病院, 特任助教 (00507791)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脾門脈外科学 / 門脈血栓症 / 肝硬変症 / 脾臓摘出術 / 血栓性素因 |
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| Research Abstract |
The aim of study is to elucidate the mechanism of portal venous thrombosis (PVT) after splenectomy in cirrhotic patients. Preoperative study showed that prothrombin time was more prolonged in PVT group than in non PVT group (p=0.0593), and value of antithrombin III was lower in PVT group (p=0.0054). In non PVT group, value of antithrombin III was recovered in a few days after splenectomy, however recovery of antithrombin III was delayed in PVT group after splenectomy and value of antithombin III was significantly lower in PVT group on 7thpostoperative day (p<0.05) than in non PVT group. It is supposed that hypercoagulopathy might be one of causes of PVT after splenectomy due to delayed functional recovery of liver.
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Report
(3 results)
Research Products
(9 results)
