antiplatelet therapy using with platelet function tests

• Project/Area Number: 23791590
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cerebral neurosurgery
• Research Institution: Gifu University
• Principal Investigator: ENOMOTO Yukiko 岐阜大学, 大学院・医学系研究科, 助教 (20377659)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 抗血小板薬 / 頚動脈狭窄症 / 血小板凝集能

Research Abstract

We reviewed the data prospectively collected from 54 patients who were randomized to clopidogrel/ aspirin or cilostazol / aspirin therapy before CAS. Blood samples had been obtained on the day of CAS to measure platelet aggregability in response to adenosine diphosphate (ADP) and collagen, VerifyNow[○!R] assay and activate platelets markers. We examined the impact of the difference of the antiplatelet therapy or platelet aggregability on the incidence of perioperative complications. There was no difference in the rate of perioperative complications after carotid artery stentingbetween clopidogrel/ aspirin group and cilostazol / aspirin group. The factors associated with perioperative complications were preoperative increased platelet aggregabilityfor ADP and collagen. Activated platelets markers were not associated.

Research Products

• [Journal Article] Selection of carotid artery stenting or endoarterectomy based on magnetic resonance plaque imaging reduced periprocedural adverse events (2012)
  • Author(s): Yoshimura S, Yamada K, Kawasaki M, Asano T, Kanematsu M, Miyai M, Enomoto Y, Egashira Y, Iwama T
  • Journal Title: J Stroke Cerebrovasc Dis Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Selection of Carotid Artery Stenting or Endarterectomy Based on Magnetic Resonance Plaque Imaging Reduced Periprocedural Adverse Events. (2012)
  • Author(s): Yoshimura S, Yamada K, Kawasaki M, Asano T, Kanematsu M, Miyai M, Enomoto Y, Egashira Y, Iwama T
  • Journal Title: J Stroke Cerebrovasc Dis
  • Peer Reviewed
• [Journal Article] Visualization of internal carotid artery atherosclerotic plaques in symptomatic and asymptomatic patients: a comparison of optical coherence tomography and intravascular ultrasound. (2012)
  • Author(s): Yoshimura S, Kawasaki M, Yamada K, Enomoto Y, Egashira Y, Hattori A, Nishigaki K, Minatoguchi S, Iwama T
  • Journal Title: AJNR Am J Neuroradiol Volume: 33(2) Pages: 308-13
  • Peer Reviewed
• [Journal Article] Selection of carotid artery stenting or endoarterectomy based on magnetic resonance plaque imaging reduced periprocedural adverse events. (2012)
  • Author(s): Yoshimura S
  • Journal Title: J Stroke Cerebrovasc Dis Volume: Aug 29
  • Peer Reviewed
• [Journal Article] 頸動脈ステント留置患者の抗血小板療法 (2012)
  • Author(s): 榎本由貴子
  • Journal Title: Circulation Volume: 12 Pages: 44-51
  • Peer Reviewed
• [Journal Article] cAMP regulates ADP-induced HSP27 phoshorylation in human platelats (2011)
  • Author(s): Enomoto Y, Adachi S, Doi T, Natsume H, Kato K, Matsushima-Nishiwaki R, Akamatsu S, Tokuda H, Yoshimura S, Otsuka T, Ogura S, Kozawa O, Iwama T
  • Journal Title: Int J Mol Med Volume: 27 Pages: 695-700
  • Peer Reviewed
• [Journal Article] Evaluation of symptomatic carotid plaques by tissue characterization using integrated backscatter ultrasound and magnetic resonance imaging. (2011)
  • Author(s): Yamada K, Kawasaki M, Yoshimura S, Enomoto Y, Asano T, Minatoguchi S, Iwama T
  • Journal Title: Cerebrovasc Dis Volume: 31(3) Pages: 305-12
  • Peer Reviewed
• [Journal Article] Embolic complications after carotid artery stenting or carotid endarterectomy are associated with tissue characteristics of carotid plaques evaluated by magnetic resonance imaging. (2011)
  • Author(s): Yamada K, Yoshimura S, Kawasaki M, Enomoto Y, Asano T, Hara A, Minatoguchi S, Iwama T
  • Journal Title: Atherosclerosis Volume: 215(2) Pages: 399-404
  • Peer Reviewed
• [Journal Article] Prediction of silent ischemic lesions after carotid artery stenting using virtual histology intravascular ultrasound (2011)
  • Author(s): Yamada K, Yoshimura S, Kawasaki M, Enomoto Y, Takano K, Asano T, Minatoguchi S, Iwama T
  • Journal Title: Cerebrovasc Dis Volume: 32(2) Pages: 106-13
  • Peer Reviewed
• [Journal Article] cAMP regulates ADP-induced HSP27 phoshorylation in human platelats. (2011)
  • Author(s): Enomoto Y, Adachi S, Doi T, Natsume H, Kato K, Matsushima- Nishiwaki R, Akamatsu S, Tokuda H, Yoshimura S, Otsuka T, Ogura S, Kozawa O, Iwama T
  • Journal Title: Int J Mol Med Volume: 27 Pages: 695-700
  • Peer Reviewed
• [Presentation] 近位閉塞法はCAS後脳塞栓症を減らすか?-術前TOF所見と使用デバイスとの関連. (2012)
  • Author(s): 渡會祐隆, 吉村紳一, 村井博文, 榎本由貴子, 岩間 亨
  • Organizer: 第28回日本脳神経血管内治療学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2012-11-16
• [Presentation] 頸部内頸動脈閉塞に対する超急性期血行再建術 (2012)
  • Author(s): 榎本由貴子, 吉村紳一, 江頭裕介, 石黒光紀, 宮居雅文, 澤田重信, 岩間 亨
  • Organizer: 第71回日本脳神経外科学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2012-10-19
• [Presentation] Correlation between light transmission aggregometry and VerifyNow assay in the patients undergoing neuroendovascular therapy (2012)
  • Author(s): Enomoto Y, Yoshimura S, Iwama T
  • Organizer: 10th Meeting of Asian-Australasian federation of interventional and therapeutic neuroradiology
  • Place of Presentation: Nagoya
  • Year and Date: 2012-06-14
• [Presentation] Correlation between light transmission aggregometry and VerifyNow assay in the patients undergoing neuroendovascular therapy. (2012)
  • Author(s): Enomoto Y
  • Organizer: 10th Meeting of Asian-Australasian federation of interventional and therapeutic neuroradiology
  • Place of Presentation: Nagoya
• [Presentation] 近位閉塞法はCAS後脳塞栓症を減らすか？－術前TOF所見と使用デバイスとの関連 (2012)
  • Author(s): 渡會祐隆
  • Organizer: 第28回日本脳神経血管内治療学会学術総会
  • Place of Presentation: 仙台
• [Presentation] VerifyNow systemと血小板凝集能検査における測定値の比較検討 (2011)
  • Author(s): 榎本由貴子, 吉村紳一, 岩間 亨
  • Organizer: 第27回日本脳神経血管内治療学会学術総会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-24
• [Presentation] CAS症例における積極CADスクリーニング (2011)
  • Author(s): 榎本由貴子, 吉村紳一, 山田清文、岩間亨
  • Organizer: 第70回日本脳神経外科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-10-12
• [Presentation] 頸動脈ステント留置術(CAS)における周術期抗血小板療法 (2011)
  • Author(s): 榎本由貴子, 吉村紳一, 山田清文, 江頭裕介, 岩間 亨
  • Organizer: 第40回日本脳卒中の外科学会
  • Place of Presentation: 京都
  • Year and Date: 2011-07-30
• [Presentation] CAS症例における積極CADスクリーニング (2011)
  • Author(s): 榎本由貴子, 吉村紳一, 山田清文、岩間亨
  • Organizer: 第10回日本頸部脳血管治療学会
  • Place of Presentation: 大阪
  • Year and Date: 2011-06-10
• [Presentation] 頸動脈ステント留置術（CAS）における周術期抗血小板療法. (2011)
  • Author(s): 榎本由貴子, 吉村紳一, 山田清文, 江頭裕介, 岩間 亨
  • Organizer: 第40回日本脳卒中の外科学会
  • Place of Presentation: 京都
• [Presentation] VerifyNow systemと血小板凝集能検査における測定値の比較検討. (2011)
  • Author(s): 榎本由貴子, 吉村紳一, 岩間 亨
  • Organizer: 第27回日本脳神経血管内治療学会学術総会
  • Place of Presentation: 千葉
• [Book] 脳血管内治療の進歩2013 (2012)
  • Author(s): 榎本由貴子
  • Publisher: 診断と治療社
• [Book] 月刊循環器12月号 (2012)
  • Author(s): 榎本由貴子, 吉村紳一
  • Publisher: 医学出版
• [Book] 脳血管内治療の進歩2011 (2011)
  • Author(s): 榎本由貴子
• [Book] 脳血管内治療の進歩2012 (2011)
  • Author(s): 榎本由貴子
  • Publisher: 診断と治療社
• [Book] 脳血管内治療の進歩2011 (2011)
  • Author(s): 榎本由貴子
  • Total Pages: 5
  • Publisher: 診断と治療社
• [Book] 脳動脈瘤血管内治療のすべて (2010)
  • Author(s): 榎本由貴子
  • Publisher: メジカルレビュー社
• [Remarks]
  • URL: http://www.med.gifu-u.ac.jp/neurosurgery/
• [Remarks] http://www.med.gifu-u.ac.jp/neurosurgery/
• [Remarks]
  • URL: http://www.med.gifu-u.ac.jp/neurosurgery/