| Project/Area Number |
23791625
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | fMRI / 経頭蓋磁気刺激 / 末梢神経電気刺激 / 筋電図 / 脊髄 / 体性感覚入力 / 機能的MRI / 大脳頚髄同時計測 / 機能的評価 / 頚髄症 |
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| Research Abstract |
We delivered suprathreshold TMS to left M1 or gave electrical right median nerve stimulation in healthy volunteers while simultaneously conducting fMRI and monitoring with EMG. We examined in detail the localization of TMS-, muscle afferent- and superficial afferent-induced activity in M1 subdivisions. Muscle afferent-and TMS-evoked activity occurred mainly in rostral M1, while superficial afferents generated a slightly different activation distribution. This result was almost consistent with the previous study in squirrel monkeys (Strick & Preston, 1982). The present study appears to justify the use of fMRI combined with suprathreshold TMS to M1 for evoked motor network imaging.
Next, we developed a novel MRI scanning technique which enables us to measure neuronal activity in the brain and the spinal cord simultaneously. Using this technique, to our knowledge, we first demonstrated a cerebrospinal functional coupling during motor tasks in human, noninvasively.
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