p21 regulate aggrecan and MMP13 expression

• Project/Area Number: 23791640
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Kobe University
• Principal Investigator: HAYASHI Shinya 神戸大学, 医学部附属病院, 特命助教 (20437487)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: p21 / 軟骨組織 / 変形性関節症 / p２１ / 軟骨 / 軟骨細胞 / メカニカルストレス / 細胞外基質 / 変性

Research Abstract

We suggest p21 maintains matrix synthesis by regulation of aggrecan and MMP-13 expression in cartilage tissue. The main function of p21 in cartilage tissue could be the regulator of transcriptional factor rather than the inhibitor of cell cycle progression. Our data imply that stabilization of p21 would be useful as a therapeutic strategy for OA treatment.

Research Products

• [Journal Article] PTEN regulates matrix synthesis in adult human chondrocytes under oxidative stress (2014)
  • Author(s): Iwasa K, Hayashi S, Fujishiro T, Kanzaki N, Hashimoto S, Sakata S, Chinzei N, Nishiyama T, Kuroda R, Kurosaka M
  • Journal Title: J Orthop Res Volume: 32 Pages: 231-7
  • Peer Reviewed
• [Journal Article] Akt phosphorylation in human chondrocytes is regulated by p53R2 in response to mechanical stress (2012)
  • Author(s): Kawakita K, Nishiyama T, Fujishiro T, Hayashi S, Kanzaki N, Hashimoto S, Takebe K, Iwasa K, Sakata S, Nishida K, Kuroda R, Kurosaka M
  • Journal Title: Osteoarthritis Cartilage Volume: 20 Pages: 1603-9
  • Peer Reviewed
• [Presentation] p21 regulates MMP-13 expression via STAT3 signaling in chondrocytes (2013)
  • Author(s): Shinya Hayashi, Shuhei Sakata, Takayuki Nishiyama, Takaaki Fujishiro, Noriyuki Kanzaki, Kohei Kawakita, Kenjiro Iwasa, Ryosuke Kuroda, Masahiro Kurosaka
  • Organizer: OARSI meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2013-04-20
• [Presentation] p21 regulates MMP-13 expression via STAT3 signaling in chondrocytes (2013)
  • Author(s): Shinya Hayashi, Shuhei Sakata, Takayuki Nishiyama, Takaaki Fujishiro, Noriyuki Kanzaki, Kohei Kawakita, Kenjiro Iwasa, Ryosuke Kuroda, Masahiro Kurosaka
  • Organizer: ORS annual meeting
  • Place of Presentation: San Antonio, USA
  • Year and Date: 2013-01-27
• [Presentation] p21 regulates MMP-13 expression via STAT3 signaling in chondrocytes. (2013)
  • Author(s): Shinya Hayashi
  • Organizer: Osteoarthritis Reserach Society International meeting 2013
  • Place of Presentation: アメリカ合衆国
• [Presentation] p21regulates MMP-13 expression and decreased aggrecan expression via STAT3/ SDF-1 pathway (2013)
  • Author(s): 林 申也
  • Organizer: Orthopaedic reserach meeting
  • Place of Presentation: サンアントニオ アメリカ
• [Presentation] p21regulates MMP-13 expression and decreased aggrecan expression via STAT3/ SDF-1 pathway (2013)
  • Author(s): 林 申也
  • Organizer: OARSI meeting
  • Place of Presentation: フィラデルフィア アメリカ
• [Presentation] p21regulates MMP-13 expression and decreased aggrecan expression via STAT3/ SDF-1 pathway (2012)
  • Author(s): Shinya Hayashi, Shuhei Sakata, Takayuki Nishiyama, Takaaki Fujishiro, Noriyuki Kanzaki, Kohei Kawakita, Kenjiro Iwasa, Ryosuke Kuroda, Masahiro Kurosaka
  • Organizer: OARSI meeting
  • Place of Presentation: Barcelona, Spain(Poster)
  • Year and Date: 2012-04-26
• [Presentation] メカニカルストレス応答性にp21^cip1はMMP13の発現を調節する (2012)
  • Author(s): 林申也、西山隆之、藤代高明、橋本慎吾、岩佐賢二郎、川北晃平、坂田周平、黒田良祐、黒坂昌弘
  • Organizer: 日本軟骨代謝学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-03-09
• [Presentation] メカニカルストレス応答性にp21cip1はMMP13の発現を調節する (2012)
  • Author(s): 林 申也
  • Organizer: 日本軟骨代謝学会
  • Place of Presentation: 愛知
• [Presentation] P21 REGULATES MMP-13 EXPRESSION ANDDECREASED AGGRECAN EXPRESSION VIA STAT3/ SDF-1 PATHWAY. (2012)
  • Author(s): Shinya Hayashi
  • Organizer: 2012 World Congress on Osteoarthritis
  • Place of Presentation: スペイン
• [Presentation] Mechanical stress increased p21cip1 expression in chondrocytes (2011)
  • Author(s): Shinya Hayashi, Shuhei Sakata, Takayuki Nishiyama, Takaaki Fujishiro, Noriyuki Kanzaki, Kohei Kawakita, Kenjiro Iwasa, Ryosuke Kuroda, Masahiro Kurosaka
  • Organizer: OARSI meeting
  • Place of Presentation: Sandiego, USA(Poster)