Tumorigenic mechanisms of gene fusion-related sarcoma: study using Ewing's sarcoma models
| Project/Area Number |
23791672
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Japanese Foundation For Cancer Research |
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Principal Investigator |
TANAKA Miwa 公益財団法人がん研究会, がん研究所 発がん研究部, 研究員 (70345883)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 骨軟部腫瘍 / 融合遺伝子 / 動物モデル / ユーイング肉腫 / 発生母地 / 発がん機構 / EWS-FLI1 / エピゲノム / キメラ遺伝子 / マウスモデル / 細胞内環境 |
|---|
| Research Abstract |
The Ewing’s sarcoma mouse models enabled us to analyze tumorigenic processes from the initial step to the highly malignant stage, and has selected important genetic pathway in the processes. Our platform combined with tests using human cell lines will allow us to explore and evaluate novel target therapies
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Report
(3 results)
Research Products
(24 results)
