| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Tail flick or formalin test demonstreated that D-amino acid deficient mice decreased pain threshold. The expressin of mRNA and protein of serine racemase and D-amino acid oxidase increased in forebrain (striatum, hippocampus, cortex) and spinal cord of neuropathic pain model (SNL model). The levels of D-serine increased in forebrain and spinal cord in SNL model. These results demonstrated that elevated D-serine level in SNL model developing neuropathic pain could at least in part be involeved in the activation of NMDA receptor via glycine site.
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