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Cancer/Testis Antigens ~The Novel Biomarker for Renal Cell Carcinoma

Research Project

Project/Area Number 23791742
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionChiba University

Principal Investigator

SUYAMA Takahito  千葉大学, 医学(系)研究科(研究院), 助教 (60400925)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords腎細胞癌 / 腫瘍マーカー / 新規バイオマーカー
Research Abstract

Renal cell carcinoma (RCC) is known to express CXCR3. CXCR3 can be considered as one of the Cancer/Testis Antigens. The function of CXCR3 on RCC has not been clarified. The aims of this study were to reveal the function of CXCR3. Fifty-six clinical samples of clear cell RCC and corresponding normal renal tissue samples were used.
CXCR3 and its ligands were abundant in RCC samples compared with corresponding normal kidney samples. CXCL10 treatment induced 786-O cell migration and invasion. In clinical samples, the expressions of CXCR3 and CXCR3-A were significantly higher in metastatic RCC than in non-metastatic RCC. Finally, the expression of CXCR3-A and hypoxia-inducible factor 1 alpha were significantly correlated in the clinical samples. Regarding 786-O, treatment with cobalt chloride (CoCl2) up-regulated CXCR3 expression 4.5-fold. We showed the association of CXCR3 and RCC metastasis. The expression of CXCR3 may be regulated by hypoxia.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] The Association of CXCR3 and Renal Cell Carcinoma Metastasis.2014

    • Author(s)
      Utsumi T, Suyama T, Imamura Y, Fuse M, Sakamoto S, Nihei N, Ueda T, Suzuki H, Seki N, Ichikawa T.
    • Journal Title

      Journal of Urology

      Volume: 8 Issue: 2 Pages: 567-574

    • DOI

      10.1016/j.juro.2014.01.100

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 腎細胞癌におけるケモカイン受容体CXCR3の転移機構への関与の検討2013

    • Author(s)
      内海孝信、巣山貴仁、今村有祐、坂本信一、仲村和芳、二瓶直樹、植田健、市川智彦
    • Organizer
      第22回泌尿器科分子細胞研究会
    • Place of Presentation
      高知
    • Year and Date
      2013-03-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 腎細胞癌におけるケモカイン受容体CXCR3の転移機構への関与の検討2013

    • Author(s)
      内海孝信、巣山貴仁
    • Organizer
      第22回泌尿器科分子・細胞研究会
    • Place of Presentation
      日本 高知
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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