Steroid sulfatase inhibitor may be one of the promising novel endocrine therapies for endometrial cancer.

• Project/Area Number: 23791802
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Tohoku University
• Principal Investigator: SHIGA Naomi 東北大学, 大学病院, 助教 (20595558)
• Research Collaborator: ITO Kiyoshi ; UTSUNOMIYA Hiroki ; NISHIMOTO Mitsuo
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 子宮内膜癌 / スルファターゼ経路 / STS阻害剤 / 共培養 / 間質細胞 / 癌局所微小環境 / アロマターゼ阻害剤

Outline of Final Research Achievements

Estrogen contributes toward the growth and development of endometrial cancer. The steroid sulfatase pathway may be related to estrogen-dependent biological characteristics. However, the role of the steroid sulfatase pathway and the possible effect of steroid sulfatase inhibitor on endometrial cancer are unclear.
Cell proliferation in endometrial cancer cells was significantly decreased by steroid sulfatase inhibitor in co-culture with stromal cells. Estrogen receptor and steroid sulfatase mRNA levels were significantly higher in co-culture with stromal cells. These data indicated the local biosynthesis of estrogens through the steroid sulfatase pathway and tumor-stromal interactions. Steroid sulfatase inhibitor may be a promising novel endocrine therapy for endometrial cancer. Our results may provide important information on the metabolism and synthesis of intratumoral estrogens with regard to the etiology and progression of endometrial cancer.

Research Products

• [Journal Article] 子宮癌肉腫における術前内幕細胞診の意義 (2014)
  • Author(s): 志賀尚美、岡本聡、海法道子、宇都宮裕貴、永瀬智、高野忠夫、新倉仁、伊藤潔、八重樫伸生
  • Journal Title: 日本臨床細胞学会雑誌 Volume: 53（1）
  • Peer Reviewed
• [Journal Article] Carcinosarcoma of the uterine cervix with a clear cell (2013)
  • Author(s): Naomi Shiga, Masafumi Toyoshima, Jun-ichi Akahira, Satoru Nagase, Hitoshi Niikura, Nobuo Yaegashi
  • Journal Title: Int Canc Conf J Volume: 2(3) Issue: 3 Pages: 154-156
  • DOI: 10.1007/s13691-012-0080-8
  • Peer Reviewed
• [Journal Article] Feasibility study of gemcitabine plus docetaxel in advanced or recurrent uterine leiomyosarcoma and undifferentiated endometrial sarcoma in Japan (2013)
  • Author(s): Takano T, Niikura H, Ito K, Nagase S, Utsunomiya H, Otsuki T, Toyoshima M, Tokunaga H, Kaiho-Sakuma M, Shiga N, Nagai T, Tanaka S, Otsuki A, Kurosawa H, Shigeta S, Yamaguchi T, Yaegashi N.
  • Journal Title: International Journal of Clinical Oncology. Volume: - Issue: 5 Pages: 897-905
  • DOI: 10.1007/s10147-013-0627-5
  • Peer Reviewed
• [Journal Article] A Case of Quiescent Nuck's Hydrocele with Endometriosis Revealed after Laparoscopic Surgery (2013)
  • Author(s): 志賀尚美、宇都宮裕貴、石橋ますみ、黒澤大樹、西本光男、渡邊善、豊島将文、渡辺正、八重樫伸生
  • Journal Title: JAPANESE JOURNAL OF GYNECOLOGIC AND OBSTETRIC ENDOSCOPY Volume: 29 Issue: 1 Pages: 168-172
  • DOI: 10.5180/jsgoe.29.168
  • NAID: 130003395864
  • ISSN: 1884-5746, 1884-9938
  • Peer Reviewed
• [Journal Article] Laparoscopic strassman metroplasty in a postmenarcheal adolescent girl with herlyn-werner-wunderlich mullerian anomaly variant, obstructed noncommunicating didelphic uterus without gartner duct pseudocyst (2013)
  • Author(s): Nabeshima H, Nishimoto M, Shiga N, Utsunomiya H, Yaegashi N.
  • Journal Title: J Minim Invasive Gynecol. Volume: 20 Pages: 255-258
  • Peer Reviewed
• [Journal Article] 性器奇形の手術 先天性腟欠損症(MRKH症候群)に対する、造腟術の検討と、新しい造腟術(Vecchietti法)の導入に関して (2012)
  • Author(s): 鍋島寛志、佐藤多代、志賀尚美、西本光男、豊島将文、齋藤純香、宇都宮裕貴、菅原準一、八重樫伸生
  • Journal Title: 産婦人科手術 Volume: 23 Pages: 33-41
• [Presentation] ストレスホルモンと癌：子宮内膜癌におけるコルチゾール代謝 (2014)
  • Author(s): 三木康宏、髙木清司、鈴木貴、笹野公伸、伊藤潔
  • Organizer: 第15回ホルモンと癌研究会
  • Place of Presentation: 東北大学医学部艮陵会館（仙台市）
  • Year and Date: 2014-07-05
• [Presentation] 類内膜型の子宮内膜癌における腫瘍組織中DHT濃度に関連した5αリダクターゼ１の意義 (2014)
  • Author(s): 田中創太、三木康宏、橋本千明、高木清司、鈴木貴、八重樫伸生、伊藤潔
  • Organizer: 第15回ホルモンと癌研究会
  • Place of Presentation: 東北大学医学部艮陵会館（仙台市）
  • Year and Date: 2014-07-04
• [Presentation] 子宮内膜癌におけるSteroid sulfatase 阻害剤の有効性に関する検討
  • Author(s): 西本光男、宇都宮裕貴、志賀尚美、海法道子、鈴木史彦、徳永英樹、伊藤潔、八重樫伸生
  • Organizer: 第61回北日本産科婦人科学会
  • Place of Presentation: 旭川
• [Presentation] Evaluation of endocervical glandular lesions using a scoring system
  • Author(s): Okamoto S, Niikura H, Takano T, Nagase S, Otsuki T, Kaiho M, Utsunomiya H, Shiga N, Yaegashi N.
  • Organizer: 18th International Congress of Cytology
  • Place of Presentation: パリ、フランス
• [Presentation] 子宮内膜癌におけるSteroid sulfatase 阻害剤の有効性に関する検討
  • Author(s): 西本光男、宇都宮裕貴、志賀尚美、辻圭太、海法道子、鈴木史彦、徳永英樹、伊藤潔、八重樫伸生
  • Organizer: 第65回日本産婦人科学会
  • Place of Presentation: 札幌
• [Presentation] 子宮内膜癌におけるSteroid Sulfatase阻害剤の有用性に関する検討
  • Author(s): 西本光男、宇都宮裕貴、志賀尚美、山下泰恒、辻圭太、海法道子、鈴木史彦、徳永英樹、伊藤潔、八重樫伸生
  • Organizer: 第25回日本内分泌学会東北地方会
  • Place of Presentation: 秋田
• [Presentation] アンドロゲン不応症姉妹例への遺伝カウンセリングの検討
  • Author(s): 志賀尚美、佐藤多代、西郡秀和、八重樫伸生
  • Organizer: 第36回日本遺伝カウンセリング学会
  • Place of Presentation: 長野
• [Presentation] 閉塞性病変を伴うMuller管発生異常症例に関する後方視的検討
  • Author(s): 志賀尚美、鍋島寛志、西本光男、佐藤多代、宇都宮裕貴、西郡秀和、鈴木吉也、菅原準一、八重樫伸生
  • Organizer: 第64回日本産科婦人科学会
  • Place of Presentation: 神戸