| Project/Area Number |
23791811
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SONE Kembun 東京大学, 医学部付属病院, 助教 (90598872)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | SIRT1 / DBC-1 / アポトーシス / カスパーゼ / E-cadherin / 子宮内膜 / 子宮体癌 / 細胞接着能 / レズベラトロール / sirtinol / 子宮体癌細胞株 |
|---|
| Research Abstract |
We elucidated function analysis of SIRT1 and DBC-1 in apoptosis. And We analyzed the function of SIRT1 in endometrium.
We confirmed that DBC-1 is targeted for cleavage by caspase-7 during the process of apoptosis. In addition, Endgeneous SIRT1 and DBC-1 localize to the nucleus in healthy cells and to the cytoplasm during apoptosis, and possibly induce apoptosis signal.
In endometrium,SIRT1 plays an important role in regulating E-cadherin and induce cell-attachment.and There is possiblility that SIRT1 is related to human cancinogene- sis in endometrium and capacity of an embrio to attach.
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