Involvement of neuropeptide to the stress-related inner ear diseases
| Project/Area Number |
23791891
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Mie University |
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Principal Investigator |
IDA-ETO Michiru 三重大学, 医学(系)研究科(研究院), 助教 (80393148)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ストレス / 内耳 / 神経ペプチド / ラット / シナプス / 発達 / 老化 |
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| Research Abstract |
Inner ear disease such as sudden deafness and Meniere disease may be caused by stress. Manserin is distributed in the neuroendocrine system and its expression in the adrenal gland is stress dependent. Recently, I found the localization of manserin in the rat inner ear. In this study, I investigated the relationship between manserin and stress condition.
Manserin localized at the neuronal terminals of the organ of Corti and spiral ganglion in the inner ear, cochlear nucleus in the medulla oblongata, and lateral superior olivary nucleus in the pons. Manserin immunoreactivity in the type II spiral ganglion cells was decreased by the stress. These results suggest that manserin may be involved in the regulation of auditory pathway under the stress condition.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Manserin as a novel histochemical neuroendocrine marker in prostate cancer.2013
Author(s)
Kouhei Nishikawa, Norihito Soga, Kenichiro Ishii, Manabu Kato, Yoichi Iwamoto, Yasuhide Hori, Michiru Etoh, Takeshi Ohkawara, Tomomi Yamada, Katsunori Uchida, Hideaki Kise, Kiminobu Arima, Masaaki Narita, Taizo Shiraishi, Yoshiki Sugimura
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Journal Title
Urologic Oncology
Volume: 31
Issue: 6
Pages: 787-795
DOI
Related Report
Peer Reviewed
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