Research for the molecular mechanism of Behcet's disease
| Project/Area Number |
23791997
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUKI Nobuhisa 横浜市立大学, 医学研究科, 教授 (90336579)
OHTSUKA Masato 東海大学, 医学部, 講師 (90372945)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 眼免疫学 / 眼遺伝学 / 自己免疫疾患 |
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| Research Abstract |
The progress and achievements of research on the new HLA-B51 transgenic mouse model of Behcet’s disease： The exact cause of Behcet’s disease is still unclear. However, it is well known that there is high incidence of HLA-B51 in patients with Behcet’s disease. In this study, we generated new transgenic mice to elucidate the function of HLA-B51 in Behcet’s disease.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B*51 and ERAP12013
Author(s)
Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Ozyazgan Y, Sacli FS, Erer B, Inoko H, Emrence Z, Cakar A, Abaci N, Ustek D, Satorius C, Ueda A, Takeno M, Kim Y, Wood GM, Ombrello MJ, Meguro A, Gul A, Remmers EF, Kastner DL
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Journal Title
Nat Genet
Volume: 45(2)
Pages: 202-7
Related Report
Peer Reviewed
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[Journal Article] Replication of a microsatellite genome-wide association study of Behcet's disease in a Korean population2012
Author(s)
Horie Y, Meguro A, Kitaichi N, Lee EB, Kanda A, Noda K, Song YW, Park KS, Namba K, Ota M, Inoko H, Mizuki N, Ishida S, Ohno S
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Journal Title
Rheumatology (Oxford)
Volume: 51(6)
Pages: 983-6
Related Report
Peer Reviewed
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[Journal Article] Association analysis of Toll-like receptor 7 gene polymorphisms and Behcet's disease in Japanese patients2011
Author(s)
Sada T, Ota M, Katsuyama Y, Meguro A, Nomura E, Uemoto R, Nishide T, Okada E, Ohno S, Inoko H, Mizuki N
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Journal Title
Hum Immunol
Volume: 72(3)
Pages: 269-72
Related Report
Peer Reviewed
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