Research for the molecular mechanism of Behcet's disease

• Project/Area Number: 23791997
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Yokohama City University
• Principal Investigator: KAWAGOE Tatsukata 横浜市立大学, 医学部, 助教 (20564800)
• Co-Investigator(Renkei-kenkyūsha): MIZUKI Nobuhisa 横浜市立大学, 医学研究科, 教授 (90336579) ; OHTSUKA Masato 東海大学, 医学部, 講師 (90372945)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 眼免疫学 / 眼遺伝学 / 自己免疫疾患

Research Abstract

The progress and achievements of research on the new HLA-B51 transgenic mouse model of Behcet’s disease： The exact cause of Behcet’s disease is still unclear. However, it is well known that there is high incidence of HLA-B51 in patients with Behcet’s disease. In this study, we generated new transgenic mice to elucidate the function of HLA-B51 in Behcet’s disease.

Research Products

• [Journal Article] Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B*51 and ERAP1 (2013)
  • Author(s): Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Ozyazgan Y, Sacli FS, Erer B, Inoko H, Emrence Z, Cakar A, Abaci N, Ustek D, Satorius C, Ueda A, Takeno M, Kim Y, Wood GM, Ombrello MJ, Meguro A, Gul A, Remmers EF, Kastner DL
  • Journal Title: Nat Genet Volume: 45(2) Pages: 202-7
  • Peer Reviewed
• [Journal Article] piggyBac-mediated generation of stable transfectants with surface human leukocyte antigen expression from a small number of cells (2013)
  • Author(s): Miura H, Inoko H, Inoue I, Okada Y, Tanaka M, Sato M, Ohtsuka M
  • Journal Title: Anal Biochem Volume: 437(1) Pages: 29-31
  • Peer Reviewed
• [Journal Article] Infliximab monotherapy versus infliximab and colchicine combination therapy in patients with Behcet's disease (2012)
  • Author(s): Takeuchi M, Asukata Y, Kawagoe T, Ito N, Nishide T, Mizuki N
  • Journal Title: Ocul Immunol Inflamm Volume: 20(3) Pages: 193-7
  • Peer Reviewed
• [Journal Article] PITT: pronuclear injection-based targeted transgenesis, a reliable transgene expression method in mice (2012)
  • Author(s): Ohtsuka M, Miura H, Sato M, Kimura M, Inoko H, Gurumurthy CB
  • Journal Title: Exp Anim Volume: 61(5) Pages: 489-502
  • NAID: 10031121853
  • Peer Reviewed
• [Journal Article] Development of a technique for efficient gene transfer to antral follicular cells in the mouse ovary (2012)
  • Author(s): Sato M, Akasaka E, Saitoh I, Ohtsuka M, Watanabe S
  • Journal Title: Syst Biol Reprod Med Volume: 58(3) Pages: 136-41
  • Peer Reviewed
• [Journal Article] Targeted transgenesis through pronuclear injection of improved vectors into in vitro fertilized eggs (2012)
  • Author(s): Ohtsuka M, Miura H, Nakaoka H, Kimura M, Sato M, Inoko H
  • Journal Title: Transgenic Res Volume: 21(1) Pages: 225-6
  • Peer Reviewed
• [Journal Article] Replication of a microsatellite genome-wide association study of Behcet's disease in a Korean population (2012)
  • Author(s): Horie Y, Meguro A, Kitaichi N, Lee EB, Kanda A, Noda K, Song YW, Park KS, Namba K, Ota M, Inoko H, Mizuki N, Ishida S, Ohno S
  • Journal Title: Rheumatology (Oxford) Volume: 51(6) Pages: 983-6
  • Peer Reviewed
• [Journal Article] Clinical Course before and after Cataract and Glaucoma Surgery under Systemic Infliximab Therapy in Patients with Behcet's Disease (2011)
  • Author(s): Nishida T, Shibuya E, Asukata Y, Nakamura S, Ishihara M, Hayashi K, Takeno M, Ishigatsubo Y, Mizuki N
  • Journal Title: Case Rep Ophthalmol Volume: 2(2) Pages: 189-92
  • Peer Reviewed
• [Journal Article] Association analysis of Toll-like receptor 7 gene polymorphisms and Behcet's disease in Japanese patients (2011)
  • Author(s): Sada T, Ota M, Katsuyama Y, Meguro A, Nomura E, Uemoto R, Nishide T, Okada E, Ohno S, Inoko H, Mizuki N
  • Journal Title: Hum Immunol Volume: 72(3) Pages: 269-72
  • Peer Reviewed
• [Presentation] ベーチェット病疾患関連遺伝子HLA-B51の機能解析 (2013)
  • Author(s): 河越龍方
  • Organizer: 日本眼科学会
  • Place of Presentation: 東京国際フォーラム (東京都)
  • Year and Date: 2013-04-04
• [Presentation] ベーチェット病疾患関連遺伝子HLA-B51の機能解析
  • Author(s): 河越龍方
  • Organizer: 日本眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)