Development ofnew drugs for the treatment of the septic shock
| Project/Area Number |
23792077
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | University of Miyazaki |
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Principal Investigator |
YANO Takeshi 宮崎大学, 医学部, 助教 (80521707)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 集中治療医学 / 敗血症 |
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| Research Abstract |
Vasodilatory septic shock is resulted from excessive vascular smooth muscle relaxation and decreased sensitivity to endogenous vasoconstrictors. Myosin phosphorylation induces smooth muscle contraction, and myosin dephosphorylation, which is occurred by myosin phosphatase, is related to muscle relaxation. In this study, we investigated whether myosin phosphatase inhibitor regulated vascular smooth muscle contraction even though presenting of sodium nitroprusside, nitric oxide donor, in aortic ring of the rats. Myosin phosphatase inhibitor had an effect of vasoconstriction in the dose dependent manner. The vasoconstriction effects were not attenuated by sodium nitroprusside. However, in vivo rat model, intravenous administration of myosin phosphatase inhibitor did not show any hemodynamic changes.
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Report
(3 results)
Research Products
(14 results)
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[Presentation] 血球貪食症候群にトロンボモデュリン製剤を投与しplasminogen activator inhibitor-1 を測定した 1 症例2012
Author(s)
矢野武志, 長浜真澄, 與那覇哲, 田村隆二, 丸田豊明, 矢野都子, 松岡博史, 押川満雄, 谷口正彦, 白阪哲朗, 恒吉勇男
Organizer
第39回日本集中治療医学会学術集会
Place of Presentation
千葉
Year and Date
2012-02-28
Related Report
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