| Project/Area Number |
23792177
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
HIRAO Kouji 徳島大学, 病院, 助教 (00581399)
|
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 自然免疫 / カテキン / 抗炎症作用 / 歯髄保護 / 歯髄炎 / 歯髄保護療法 / Toll-Like Receptor / NOD |
|---|
| Research Abstract |
Pulpitis, dental pulpal inflammation, is mainly associated with the dental caries-related pathogen invaded into dentinal tubles. Many types of cytokines and inflammatory mediators are induced for the initiation and progression of pulpitis. This study has demonstrated that HMGB1 and MINCLE were up-regulated by the stimulation with the ligands of innate immune receptors and the up-regulated expression of these mediators was inhibited by catechin. Moreover, this study was suggested that the binding of pathogen on cell surface receptors were inhibited by catechin.
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