Analysis of the establishment and the resistance mechanism of the Docetaxel-resistant oral squamous cell carcinoma

• Project/Area Number: 23792351
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: TAKAMARU Natsumi 徳島大学, 病院, 助教 (40513031)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 耐性株 / DOC / 口腔扁平上皮癌

Research Abstract

We used B88 cell and CAL27 cell line which were the culture human oral squamous cell carcinoma cell line which we established in our classroom. Cancer cells to use in this study confirmed that a cell proliferation was inhibited by DOC and we gave DOC 1,10,100,1000pg/ml and sequential level and cultured both cells and manufactured cell line indicating the resistance in DOC. Both cells raise the density of DOC and treat it, and the cancer cells indicating the DOC resistance are establishing it than parent cells.