Involvement of signal pathway and apoptosis of cardioprotection by regular ethanol consumption

• Project/Area Number: 23792395
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Osaka Dental University
• Principal Investigator: KANEDA Kazuhiro 大阪歯科大学, 歯学部, 講師(非常勤) (90533886)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 虚血心筋 / 心筋保護 / エタノール / シグナル伝達 / アポトーシス

Research Abstract

Bradykinin has been implicated in ischemic preconditioning and has been shown to induce mitochondrial reactive oxygen species generation through nitric oxide (NO). I investigated the involvement of the bradykinin B2 receptor (BKB2R) and measured NO production in chronic ethanol-induced cardioprotection.

Research Products

• [Journal Article] Sevoflurane confers additive cardioprotection to ethanol preconditioning associated with enhanced phosphorylation of glycogen synthase kinase-3s and inhibition of mitochondrial permeability transitionpore opening (2012)
  • Author(s): Onishi A, Miyamae M, Inoue H, Kaneda K, Okusa C, Inamura Y, Shiomi M, Koshinuma S, Momota Y, Figueredo VM
  • Journal Title: J Cardiothorac Vasc Anesth Volume: - Issue: 5 Pages: 916-924
  • DOI: 10.1053/j.jvca.2012.10.002
  • Peer Reviewed
• [Journal Article] Direct evidence for inhibition of mitochondrial permeability transition pore opening by sevoflurane preconditioning in cardiomyocytes:Comparison with cyclosporine A. (2012)
  • Author(s): Onishi A, Miyamae M, Kaneda K, KotaniJ, Figueredo VM.
  • Journal Title: Eur J Pharmacol Volume: 657 Issue: 1-3 Pages: 40-46
  • DOI: 10.1016/j.ejphar.2011.11.040
  • Peer Reviewed
• [Journal Article] Sevoflurane Confers Additive Cardioprotection to Ethanol Preconditioning Associated With Enhanced Phosphorylation of Glycogen Synthase Kinase-3β and Inhibition of Mitochondrial Permeability Transition Pore Opening. (2012)
  • Author(s): Onishi A.
  • Journal Title: J Cardiothorac Vasc Anesth Volume: -
  • Peer Reviewed
• [Presentation] 心筋虚血再灌流障害におけるnecroptosisの関与 (2012)
  • Author(s): 越沼静
  • Organizer: 第40回日本歯科麻酔学会総会・学術集会
  • Place of Presentation: アクロス福岡(福岡市)
  • Year and Date: 2012-10-06
• [Presentation] セボフルランポストコンディショニングの虚血心筋保護効果にはオートファジーの誘導が必要である (2012)
  • Author(s): 稲村吉高
  • Organizer: 第40回日本歯科麻酔学会総会・学術集会
  • Place of Presentation: アクロス福岡(福岡市)
  • Year and Date: 2012-10-06
• [Presentation] セボフルラン・エタノールによる心筋プレコンディショイングの細胞内メカニズムの解明 (2012)
  • Author(s): 大西杏奈
  • Organizer: 第9回日本歯科麻酔学会中国・四国地方会
  • Place of Presentation: 岡山大学(岡山市)
  • Year and Date: 2012-07-29
• [Presentation] セボフルランポストコンディショニングの虚血心筋保護効果にはオートファジーの誘導が必要である (2012)
  • Author(s): 稲村吉高
  • Organizer: 日本麻酔科学会第59回学術集会
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2012-06-08
• [Presentation] 心筋虚血前のオートファジーの誘導は長時間虚血により消失したセボフルランプレコンディショニング効果を回復させる (2012)
  • Author(s): 塩見真由美
  • Organizer: 日本麻酔科学会第59回学術集会
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2012-06-08
• [Presentation] Lidocaine postconditioning attenuates myocardial infarct size in vivo rabbits hearts: role of extracellular signal-regulated kinase1/2 ERK 1/2 (2012)
  • Author(s): Yamabayashi K
  • Organizer: 3th International Dental Congress on Anesthesia, Sedation, and Pain Control
  • Place of Presentation: Kona, Hawaii (USA)
  • Year and Date: 2012-03-02
• [Presentation] Cerebral protection effects of lidocaine using a transient cortical ischemia model (2012)
  • Author(s): Momota Y
  • Organizer: 3th International Dental Congress on Anesthesia, Sedation, and Pain Control
  • Place of Presentation: Kona, Hawaii (USA)
  • Year and Date: 2012-03-02
• [Presentation] Lidocaine postconditioning attenuates myocardial infarct size in vivo rabbits hearts: role of extracellular signal-regulated kinase 1/2 ERK 1/2. (2012)
  • Author(s): Yamabayashi K.
  • Organizer: 13th International Dental Congress on Anesthesia, Sedation, and Pain Control
  • Place of Presentation: Kona (Hawaii)
• [Presentation] Cerebral protection effects of lidocaine using a transient cortical ischemia model. (2012)
  • Author(s): Momota Y.
  • Organizer: 13th International Dental Congress on Anesthesia, Sedation, and Pain Control
  • Place of Presentation: Kona (Hawaii)
• [Presentation] セボフルランプレコンディショニングはcyclosporineAと同程度にミトコンドリア膜遷移透過性ポア開口を抑制し心筋保護をもたらす (2011)
  • Author(s): 大西杏奈
  • Organizer: 第531回大阪歯科学会例会
  • Place of Presentation: 大阪歯科大学(枚方市)
  • Year and Date: 2011-12-10
• [Presentation] Sevoflurane postconditioning reduces myocardial ischemia-reperfusion injury by induction of autophagy in isolated guinea pig hearts (2011)
  • Author(s): Inamura Y
  • Organizer: 9th International Congress on Coronary Artery Disease (ICCAD) from Prevention to Intervention 2011
  • Place of Presentation: Venive (Italy)
  • Year and Date: 2011-10-25
• [Presentation] Dipyridamole-induced cardiac preconditioning persists for3 days after discontinuing therapy and is mediated through Akt activation (2011)
  • Author(s): Okusa C
  • Organizer: 9th International Congress on Coronary Artery Disease (ICCAD) from Prevention to Intervention 2011
  • Place of Presentation: Venive (Italy)
  • Year and Date: 2011-10-25
• [Presentation] Sevoflurane enhances ethanol preconditioning associated with augmenting phosphorylation of GSK3β; and inhibition of MPTP opening (2011)
  • Author(s): Onishi A
  • Organizer: American Society of Anesthesiology2011
  • Place of Presentation: Chicago, Illinois(USA)
  • Year and Date: 2011-10-18
• [Presentation] Induction of autophagy restores the loss of sevoflurane preconditioning (2011)
  • Author(s): Shiomi M
  • Organizer: American Society of Anesthesiology 2011
  • Place of Presentation: Chicago, Illinois (USA)
  • Year and Date: 2011-10-16
• [Presentation] Direct evidence for inhibition of mitochondrial permeability transition pore opening by sevoflurane preconditioning in cardiomyocytes: Comparison with cyclosporine A (2011)
  • Author(s): Onishi A
  • Organizer: The 4th Annual Meeting of Federation of Asian Dental Anesthesiology Societies
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2011-10-08
• [Presentation] Direct evidence for inhibition of mitochondrial permeability transition pore opening by sevoflurane preconditioning in cardiomyocytes: Comparison with cyclosporine A. (2011)
  • Author(s): Onishi A.
  • Organizer: The 4th Annual Meeting of Federation of Asian Dental Anesthesiology Societies
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] Induction of autophagy restores the loss of sevoflurane preconditioning. (2011)
  • Author(s): Shiomi M.
  • Organizer: American Society of Anesthesiology 2011
  • Place of Presentation: Chicago, Illinois (USA)
• [Presentation] Sevoflurane enhances ethanol preconditioning associated with augmenting phosphorylation of GSK3β; and inhibition of MPTP opening. (2011)
  • Author(s): Onishi A.
  • Organizer: American Society of Anesthesiology 2011
  • Place of Presentation: Chicago, Illinois (USA)
• [Presentation] Dipyridamole-induced cardiac preconditioning persists for 3 days after discontinuing therapy and is mediated through Akt activation. (2011)
  • Author(s): Okusa C.
  • Organizer: 9th International Congress on Coronary Artery Disease (ICCAD) from Prevention to Intervention 2011
  • Place of Presentation: Venice (Italy)
• [Presentation] Sevoflurane postconditioning reduces myocardial ischemia-reperfusion injury by induction of autophagy in isolated guinea pig hearts. (2011)
  • Author(s): Inamura Y.
  • Organizer: 9th International Congress on Coronary Artery Disease (ICCAD) from Prevention to Intervention 2011
  • Place of Presentation: Venice (Italy)
• [Presentation] セボフルランプレコンディショニングはcyclosporine Aと同程度にミトコンドリア膜遷移透過性ポア開口を抑制し心筋保護をもたらす． (2011)
  • Author(s): 大西杏奈
  • Organizer: 第531回大阪歯科学会例会
  • Place of Presentation: 大阪歯科大学（枚方市）
• [Presentation] 心筋虚血前のオートファジーの誘導は長時間虚血により消失したセボフルランプレコンディショニング効果を回復させる．
  • Author(s): 塩見真由美
  • Organizer: 日本麻酔科学会第59回学術集会
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] セボフルランポストコンディショニングの虚血心筋保護効果にはオートファジーの誘導が必要である．
  • Author(s): 稲村吉高
  • Organizer: 日本麻酔科学会第59回学術集会
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] セボフルラン・エタノールによる心筋プレコンディショイングの細胞内メカニズムの解明．
  • Author(s): 大西杏奈
  • Organizer: 第9回日本歯科麻酔学会中国・四国地方会
  • Place of Presentation: 岡山大学（岡山市）
• [Presentation] セボフルランポストコンディショニングの虚血心筋保護効果にはオートファジーの誘導が必要である．
  • Author(s): 稲村吉高
  • Organizer: 第40回日本歯科麻酔学会総会・学術集会
  • Place of Presentation: アクロス福岡（福岡市）
• [Presentation] 心筋虚血再灌流障害におけるnecroptosisの関与．
  • Author(s): 越沼 静
  • Organizer: 第40回日本歯科麻酔学会総会・学術集会
  • Place of Presentation: アクロス福岡（福岡市）