Molecular genetic investigation of size of mandibular angle in consomic mice
| Project/Area Number |
23792450
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
OGAWA kei 日本大学, 松戸歯学部, 助教 (20453889)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 下顎角の大きさ / マウス / ラット / 遺伝子 / micro-CT / 下顎骨 / 下顎角 / 近郊系マウス / コンソミックマウス / 近交系マウス |
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| Research Abstract |
The aim of this study was to identify the chromosomes harboring candidate causative genes for size of mandibular angle using DNA from mice with different size of mandibular angle. Using DNA markers with polymorphisms in the C3H and B6 strains, linkage analysis and quantitative trait locus analysis were conducted. This suggests that the candidate chromosomes harboring causative genes for mandibular angle are linked with D13Mit76. Furthermore consomic mice mandibular angle were measured, it was suggested that the No.13 chromosome is concerned with regulation.
Furthermore the objective of this study was to elucidate the influence by an environmental factor on the jawbone over time. Micro-CT was used to scan the heads of rats that underwent extraction of all maxillary molars at age 5 weeks and were reared on a powdered diet, and changes in jawbone morphology up to 20 weeks were investigated. In the extraction group, mandibular angle was significantly larger from 7 weeks to 20 weeks.
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Report
(4 results)
Research Products
(10 results)
