The recovery mechanism and cell injury from orthodontic treatment with promoter of transplanted bone marrow-derived cell migration into periodontal tissues
| Project/Area Number |
23792456
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
MURAOKA Rina 松本歯科大学, 歯学部, 助教 (20549430)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 骨髄幹細胞 / 歯根膜 / 歯周組織 / 歯科矯正学 / 治療 / 修復 / 再生 / リモデリング / 細胞分化 / 組織修復 |
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| Research Abstract |
In this study, we aimed that the elucidation of the molecular regulation mechanism of recovery and cytotoxicity of periodontal tissue by orthodontic mechanical stress, and to clarify the development of the control method, the full particulars of the function and dynamics of bone marrow-derived cell.
Using the mouse that performed the bone marrow-derived cell transplantation, and were elucidated the involvement of bone marrow-derived cell in the surrounding bone and tissue study of cell injury to receive the periodontal ligament fibroblasts in particular periodontal ligament tissue loaded with orthodontic academic ability in mouse molars. Bone marrow stem cells were shown to engraft in a thriving site remodeling mostly in periodontal tissue showed experimentally that this phenomenon is associated with the dense and cells of the nervous system.
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Report
(4 results)
Research Products
(40 results)
