• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Effects of the Neutrophil Elastase on periodontal ligament cells and the clinical application of Neutrophil Elastase inhibitor to periodontal disease.

Research Project

Project/Area Number 23792489
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Periodontal dentistry
Research InstitutionTsurumi University

Principal Investigator

UJIIE Yuko  鶴見大学, 歯学部, 助教 (60588599)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords歯周予防学 / 好中球エラスターゼ / シベレスタット / 歯周病 / 歯根膜細胞 / 好中球エラスターゼ阻害剤 / 慢性歯周病疾患モデル / 破骨細胞
Research Abstract

It is known that Neutrophil Elastase is one of the neutral proteinase and it degrade foreign objects at the inflammatory situation. The proteinase increased in the periodontal ligament which supports teeth, and it degraded non-collagenous matrix of periodontal ligaments. At this experiment, we demonstrated that the neutrophil elastase related with the degradation of periodontal ligament and bone matrix. Additionally, we implied a possibility that the inhibitor of neutrophil elastase restrained the differentiation of osteoclasts, moreover, the inhibitor suppressed a degradation of periodontal ligaments.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (2 results)

All 2013

All Presentation (2 results)

  • [Presentation] 好中球エラスターゼ阻害剤が骨吸収に及ぼす影響2013

    • Author(s)
      氏家優子
    • Organizer
      日本歯周病学会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2012 Final Research Report
  • [Presentation] 好中球エラスターゼ阻害剤が骨吸収に及ぼす影響2013

    • Author(s)
      氏家優子
    • Organizer
      日本歯周病学会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi