Development of micro circulation camera device for analysis of total artificial heart driving pattern

• Project/Area Number: 23800020
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: The University of Tokyo
• Principal Investigator: INOUE Yusuke 東京大学, 大学院・工学系研究科, 特任研究員 (80611079)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 微小循環 / 血管新生 / 人工心臓 / 拍動流 / 顕微鏡 / 完全人工心臓 / 体内埋込型カメラ / 超小型顕微鏡 / 足場材料 / 拍動流・連続流 / 循環生理学 / カメラ / TAH

Research Abstract

We developed implantable microscope for micro circulation. We developed 3 type diameter device. The observation microscope has scaffold for angiogenesis. And we get stable data with this device. We experiment 6 times use with Total Artificial Heart. The animal with artificial heart living 121days maximum, and we observed our observation device. We change the heart drive pattern, exercise stress test, dose a medicine. We analyze the data. We found the difference of flow in the micro circulation via pattern of artificial heart moving.

Research Products

• [Journal Article] The helical flow pump with a hydrodynamic levitation impeller (2012)
  • Author(s): Abe Y, Ishii K, Isoyama T, Saito I, Inoue Y, Ono T, Nakagawa H, Nakano E, Fukazawa K, Ishihara K, Fukunaga K, Ono M, Imachi K
  • Journal Title: J Artif Organs Volume: 15 Issue: 4 Pages: 331-340
  • DOI: 10.1007/s10047-012-0659-z
  • NAID: 10031145870
  • Peer Reviewed
• [Journal Article] Development of Normal-Suction Boundary Control Method Based on Inflow Cannula Pressure Waveform for the Undulation Pump Ventricular Assist Device (2012)
  • Author(s): Kohei Ishii, Itsuro Saito, Takashi Isoyama, Hidemoto Nakagawa, Nakano Emiko, Toshiya Ono, Wei Shi, Yusuke Inoue, and Yusuke Abe
  • Journal Title: Artificial Organs Volume: 36(9) Issue: 9 Pages: 812-816
  • DOI: 10.1111/j.1525-1594.2012.01451.x
  • Peer Reviewed
• [Journal Article] Development of an implantable small camera for angiogenesis (2011)
  • Author(s): Yusuke Inoue, et al
  • Journal Title: ASAIO Journal Volume: 57-2 Issue: 2 Pages: 123-123
  • DOI: 10.1097/01.mat.0000395437.21150.99
  • Peer Reviewed
• [Presentation] 螺旋流血液ポンプの原理の検討 (2013)
  • Author(s): 石井耕平、細田享平、磯山隆、斎藤逸郎、有吉洸希、井上雄介、佐藤雅巳、原伸太郎、李欣陽、呉昇原、小野俊哉、中川英元、井街宏、阿部裕輔
  • Organizer: 第41回人工心臓と補助循環懇話会学術集会
  • Place of Presentation: 信州湯田中温泉よろづや
  • Year and Date: 2013-02-02
• [Presentation] 完全人工心臓用螺旋流血液ポンプの内部流れ解析 (2013)
  • Author(s): 石井耕平、西田正浩、細田享平、磯山隆、有吉洸希、斎藤逸郎、中川英元、小野俊哉、井上雄介、井街宏、阿部裕輔
  • Organizer: 日本機械学会第25回バイオエンジニアリング講演会
  • Place of Presentation: 産業技術総合研究所つくばセンター
• [Presentation] 螺旋流血液ポンプの溶血特性向上に向けた検討 (2012)
  • Author(s): 石井耕平、細田享平、磯山隆、有吉洸希、斎藤逸郎、井上雄介、佐藤雅巳、原伸太郎、小野俊哉、中川英元、井街宏、阿部裕輔
  • Organizer: 第50回日本人工臓器学会大会
  • Place of Presentation: 福岡(アクロス福岡)
  • Year and Date: 2012-11-23
• [Presentation] 螺旋流型補助人工心臓用ハイブリッド脱血カニューレの研究 (2012)
  • Author(s): 井上雄介,中野英美子,磯山隆,斎藤逸郎,小野俊哉,石井耕平,佐藤雅巳,原信太郎,呉昇原,李欣陽,有吉洸希,細田享平,川瀬由希乃,中川基貴,中川英元,関野正樹,井街宏,阿部裕輔
  • Organizer: 第50回日本人工臓器学会大会
  • Place of Presentation: 福岡(アクロス福岡)
  • Year and Date: 2012-11-23
• [Presentation] 完全人工心臓用螺旋流血液ポンプの基礎特性解析 (2012)
  • Author(s): 石井耕平、細田享平、西田正浩、磯山隆、有吉洸希、斎藤逸郎、中川英元、小野俊哉、井上雄介、井街宏、阿部裕輔
  • Organizer: 定常流ポンプ研究会2012
  • Place of Presentation: 福岡(アクロス福岡)
  • Year and Date: 2012-11-22
• [Presentation] The helical flow pump and the helical flow total artificial heart (2012)
  • Author(s): Yusuke Abe, Kohei Ishii, Takashi Isoyama, Itsuro Saito, Yusuke Inoue, Toshiya Ono, Hidemoto Nakagawa, Kou Imachi
  • Organizer: 39th Congress of ESAO
  • Place of Presentation: Academy of Music and Theatre, Rostock, Germany
  • Year and Date: 2012-09-29
• [Presentation] DEVELOPMENT OF HYBRID INFLOW CANNULA FOR VENTRICULAR ASSIST DEVICES (2012)
  • Author(s): Yusuke Inoue, Emiko Nakano, Itsuro Saito, Takashi Isoyama, Hidemoto Nakagawa, Toshiya Ono, Kohei Ishii, Koki Ariyoshi, Kou Imachi, Yusuke Abe
  • Organizer: 39th Congress of ESAO
  • Place of Presentation: Academy of Music and Theatre, Rostock, Germany
  • Year and Date: 2012-09-28
• [Presentation] The helical flow total artificial heart: initial results of animal experiment (2012)
  • Author(s): Yusuke Abe, Kohei Ishii, Takashi Isoyama, Itsuro Saito, Yusuke Inoue, Hidemoto Nakagawa, Toshiya Ono, Kazuhiko Ishihara, Minoru Ono, Kou Imachi
  • Organizer: ISRBP2012 (20th Congress of the International Society for Rotary Blood Pumps)
  • Place of Presentation: Grand Cevahir Hotel, Istanbul, Turkey
  • Year and Date: 2012-09-22
• [Presentation] Development of Hybrid Inflow Cannula for Helical Flow Ventricular Assist Device (2012)
  • Author(s): Yusuke Inoue, Emiko Nakano, Itsuro Saito, Takashi Isoyama, Hidemoto Nakagawa, Toshiya Ono, Kohei Ishii, Koki Ariyoshi,Kou Imachi, Yusuke Abe
  • Organizer: ISRBP2012 (20th Congress of the International Society for Rotary Blood Pumps)
  • Place of Presentation: Grand Cevahir Hotel, Istanbul, Turkey
  • Year and Date: 2012-09-21
• [Presentation] CFD解析に基づいた人工心臓血液ポンプの設計 (2012)
  • Author(s): 細田恭平
  • Organizer: 第14回生体物理医学専攻セミナー
  • Place of Presentation: 東京(東京大学医学部付属病院)
  • Year and Date: 2012-06-20
• [Presentation] The helical flow total artificial heart: design concept and initial development (2012)
  • Author(s): Yusuke Abe, Kohei Ishii, Takashi Isoyama, Itsuro Saito, Yusuke Inoue, Toshiya Ono, Hidemoto Nakagawa, Kazuhiko Ishihara, Minoru Ono, Kou Imachi
  • Organizer: ASAIO 58th annual conference
  • Place of Presentation: Fairmont San Franciscol, San Francisco, California, USA
  • Year and Date: 2012-06-15
• [Presentation] Development of an Implantable Small Observation Camera with Scaffold Chamber for Angiogenesis (2012)
  • Author(s): Yusuke Inoue, Itsuro Saito, Takashi Isoyama, Hidemoto Nakagawa, Toshiya Ono, Kohei Ishii, Koki Ariyoshi, Emiko Nakano, Kou Imachi, Yusuke Abe
  • Organizer: World Congress 2012 Medical Physics and Biomedical Engineering
  • Place of Presentation: Beijing International Convention Center, Beijing, China
  • Year and Date: 2012-05-27
• [Presentation] 螺旋流完全人工心臓の開発 (2012)
  • Author(s): 阿部裕輔、石井耕平、磯山隆、斉藤逸郎、井上雄介、小野俊哉、中川英元、中野英美子、深沢今日子、石原一彦、福長一義、小野稔、井街宏
  • Organizer: 第51回日本生体医工学会大会
  • Place of Presentation: 福岡(福岡国際会議場)
  • Year and Date: 2012-05-11
• [Presentation] ハイブリッド型人工材料を用いた補助人工心臓用脱血カニューレの開発 (2012)
  • Author(s): 井上雄介,中野英美子,磯山隆,斎藤逸郎,中川英元,小野俊哉,石井耕平,有吉洸希,細田享平,井街宏,阿部裕輔
  • Organizer: 第51回日本生体医工学会大会
  • Place of Presentation: 福岡(福岡国際会議場)
  • Year and Date: 2012-05-11
• [Presentation] 螺旋流完全人工心臓のための動圧軸受の開発 (2012)
  • Author(s): 石井耕平、細田享平、磯山隆、有吉洸希、斎藤逸郎、大橋広宜、中川英元、小野俊哉、井上雄介、中野英美子、井街宏、阿部裕輔
  • Organizer: 第51回日本生体医工学会大会
  • Place of Presentation: 福岡(福岡国際会議場)
  • Year and Date: 2012-05-10
• [Presentation] 螺旋流人工心臓システムの研究と開発 (2012)
  • Author(s): 井上雄介
  • Organizer: 医用アクチュエーション研究会(招待講演)
  • Place of Presentation: 東北大学、(宮城県仙台市)
  • Year and Date: 2012-03-30
• [Presentation] 螺旋流人工心臓システムの研究と開発 (2012)
  • Author(s): 井上雄介
  • Organizer: 医用アクチュエーション研究会
  • Place of Presentation: 東北大学(宮城県仙台市)(招待講演)
  • Year and Date: 2012-03-30
• [Presentation] 生体内血管新生における細胞播種による影響の観察 (2012)
  • Author(s): 井上雄介
  • Organizer: 第24回代用臓器再生医学研究会
  • Place of Presentation: 北海道大学(北海道札幌市)
  • Year and Date: 2012-01-28
• [Presentation] 完全人工心臓における微小樹幹血行動態の実時間観察 (2011)
  • Author(s): 井上雄介
  • Organizer: 第49回日本人工臓器学会
  • Place of Presentation: 都市センターホテル(東京都千代田区)
  • Year and Date: 2011-11-27
• [Presentation] GRANT成果報告:完全人工心臓における微小循環動態の実時間観察 (2011)
  • Author(s): 井上雄介
  • Organizer: 第49回日本人工臓器学会
  • Place of Presentation: 日本都市センターホテル(東京都千代田区)
  • Year and Date: 2011-11-26
• [Presentation] Development of an implantable small camera for angiogenesis (2011)
  • Author(s): Yusuke Inoue
  • Organizer: XXXVIII Congress of the European Society for Artificial Ogans
  • Place of Presentation: ポ ルトコングレスセンター(ポルトガル)
  • Year and Date: 2011-09-11
• [Presentation] Development of an implantable small camera for angiogenesis (2011)
  • Author(s): Yusuke Inoue
  • Organizer: XXXVIII Congress of the European Society for Artificial Ogans
  • Place of Presentation: ポルトコングレスセンター(ポルトガル)
  • Year and Date: 2011-09-11
• [Presentation] ハイブリッド型人工材料を用いた補助人工心臓用脱血カニューレの開発
  • Author(s): 井上雄介
  • Organizer: 第51回日本生体医工学会大会
  • Place of Presentation: 福岡(福岡国際会議場)
• [Presentation] Development of an Implantable Small Observation Camera with Scaffold Chamber for Angiogenesis
  • Author(s): Yusuke Inoue
  • Organizer: World Congress 2012 Medical Physics and Biomedical Engineering
  • Place of Presentation: Beijing International Convention Center, Beijing, China
• [Presentation] Hyderodynamic bearing for the helical flow total artificial heart
  • Author(s): Kohei Ishii
  • Organizer: ASAIO 58th annual conference
  • Place of Presentation: Fairmont San Franciscol, San Francisco, California, USA
• [Presentation] The helical flow total artificial heart: design concept and initial development
  • Author(s): Yusuke Abe
  • Organizer: ASAIO 58th annual conference
  • Place of Presentation: Fairmont San Franciscol, San Francisco, California, USA
• [Presentation] Development of Hybrid Inflow Cannula for Helical Flow Ventricular Assist Device
  • Author(s): Yusuke Inoue
  • Organizer: ISRBP2012 (20th Congress of the International Society for Rotary Blood Pumps)
  • Place of Presentation: Grand Cevahir Hotel, Istanbul, Turkey
• [Presentation] The helical flow total artificial heart: initial results of animal experiment
  • Author(s): Yusuke Abe
  • Organizer: ISRBP2012 (20th Congress of the International Society for Rotary Blood Pumps)
  • Place of Presentation: Grand Cevahir Hotel, Istanbul, Turkey
• [Presentation] DEVELOPMENT OF HYBRID INFLOW CANNULA FOR VENTRICULAR ASSIST DEVICES
  • Author(s): Yusuke Inoue
  • Organizer: 39th Congress of ESAO
  • Place of Presentation: Academy of Music and Theatre, Rostock, Germany
• [Presentation] The helical flow pump and the helical flow total artificial heart
  • Author(s): Yusuke Abe
  • Organizer: 39th Congress of ESAO
  • Place of Presentation: Academy of Music and Theatre, Rostock, Germany
• [Presentation] CFD解析を用いたEmergency Life Support System用血液ポンプ最適設計についての検討
  • Author(s): 有吉洸希
  • Organizer: 日本生体医工学会 関東支部 若手研究者発表会２０１１
  • Place of Presentation: 東京（東京都市大学）
• [Presentation] 完全人工心臓用螺旋流血液ポンプの基礎特性解析
  • Author(s): 石井耕平
  • Organizer: 日本定常流ポンプ研究会2012
  • Place of Presentation: 福岡(アクロス福岡)
• [Presentation] CFD解析によるEmergency Life Support System（ELSS）用血液ポンプ設計
  • Author(s): 有吉洸希
  • Organizer: 第50回日本人工臓器学会大会
  • Place of Presentation: 福岡(アクロス福岡)
• [Presentation] 螺旋流型補助人工心臓用ハイブリッド脱血カニューレの研究
  • Author(s): 井上雄介
  • Organizer: 第50回日本人工臓器学会大会
  • Place of Presentation: 福岡(アクロス福岡)
• [Presentation] 螺旋流完全人工心臓におけるテーブル型流量差圧推定モデルの構築
  • Author(s): 原伸太郎
  • Organizer: 第50回日本人工臓器学会大会
  • Place of Presentation: 福岡(アクロス福岡)
• [Presentation] 螺旋流血液ポンプにおける流路形状と内部流れの関係に関する研究
  • Author(s): 細田享平
  • Organizer: 第50回日本人工臓器学会大会
  • Place of Presentation: 福岡(アクロス福岡)
• [Presentation] 螺旋流血液ポンプの溶血特性向上に向けた検討
  • Author(s): 石井耕平
  • Organizer: 第50回日本人工臓器学会大会
  • Place of Presentation: 福岡(アクロス福岡)
• [Presentation] 螺旋流血液ポンプの原理の検討
  • Author(s): 石井耕平
  • Organizer: 第41回人工心臓と補助循環懇話会学術集会
  • Place of Presentation: 信州湯田中温泉よろづや
• [Remarks]
  • URL: http://www.bme.gr.jp/
• [Remarks] 東京大学関野研究室
  • URL: http://www.bee.t.u-tokyo.ac.jp/index_j.html
• [Remarks] 東京大学医用生体工学講座
  • URL: http://www.bme.gr.jp
• [Remarks]
  • URL: http://www.bme.gr.jp