Potential role of lactate in exercise-induced mitochondrial biogenesis
| Project/Area Number |
23800021
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Sports science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HOSHINO Daisuke 東京大学, 大学院・総合文化研究科, 助教 (70612117)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 乳酸 / ミトコンドリア / 骨格筋 / 運動 / 脂肪酸代謝 |
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| Research Abstract |
We examined whether lactate accumulation associate with exercise-induced mitochondrial biogenesis. We found that dichloroacetate (DCA) injection can decrease muscle and plasma lactate concentration during exercise. DCA injection and exercise were performed in mice for 4 weeks. As a result, the decrease in lactate accumulation by DCA administration attenuated increases in mitochondrial proteins with exercise training. This result suggests that lactate can be a signal for exercise-induced mitochondrial biogenesis in skeletal muscle.
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Report
(3 results)
Research Products
(12 results)
