Potential role of lactate in exercise-induced mitochondrial biogenesis

• Project/Area Number: 23800021
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Sports science
• Research Institution: The University of Tokyo
• Principal Investigator: HOSHINO Daisuke 東京大学, 大学院・総合文化研究科, 助教 (70612117)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 乳酸 / ミトコンドリア / 骨格筋 / 運動 / 脂肪酸代謝

Research Abstract

We examined whether lactate accumulation associate with exercise-induced mitochondrial biogenesis. We found that dichloroacetate (DCA) injection can decrease muscle and plasma lactate concentration during exercise. DCA injection and exercise were performed in mice for 4 weeks. As a result, the decrease in lactate accumulation by DCA administration attenuated increases in mitochondrial proteins with exercise training. This result suggests that lactate can be a signal for exercise-induced mitochondrial biogenesis in skeletal muscle.

Research Products

• [Journal Article] High-intensity interval training increases intrinsic rates of mitochondrial fatty acid oxidation in rat red and white skeletal muscle (2013)
  • Author(s): Daisuke Hoshino, Yuko Yoshida, Yu Kitaoka, Hideo Hatta, Arend Bonen.
  • Journal Title: Appl Physiol Nutr Metab Volume: 38 Issue: 3 Pages: 326-333
  • DOI: 10.1139/apnm-2012-0257
  • Peer Reviewed
• [Journal Article] Adaptation of monocarboxylate transporters in skeletal muscle (2012)
  • Author(s): Daisuke Hoshino, Yu Kitaoka, Hiroyuki Masuda, Hideo Hatta
  • Journal Title: Adaptive medicine Volume: 4 Pages: 2-9
  • DOI: 10.4247/am.2012.abb011
• [Journal Article] Monocarboxylate transporter and lactate metabolism (2012)
  • Author(s): Yu Kitaoka, Daisuke Hoshino, Hideo Hatta
  • Journal Title: The Journal of Physical Fitness and Sports Medicine Volume: 1 Issue: 2 Pages: 247-252
  • DOI: 10.7600/jpfsm.1.247
  • NAID: 10031158951
  • ISSN: 2186-8123, 2186-8131
  • URL: http://dx.doi.org/
• [Journal Article] Adaptation of monocarboxylate transporters in skeletal muscle (2012)
  • Author(s): Daisuke Hoshino, Yu Kitaoka, Hiroynki Masuda, Hideo Hatta
  • Journal Title: Adaptive Medicine Volume: 4 Pages: 2-9
  • Peer Reviewed
• [Presentation] 乳酸は骨格筋のミトコンドリア新生のシグナルとなるのか? (2013)
  • Author(s): 星野太佑
  • Organizer: 第8回乳酸研究会
  • Place of Presentation: 東京大学
  • Year and Date: 2013-02-16
• [Presentation] 乳酸は骨格筋のミトコンドリア新生のシグナルとなるのか (2013)
  • Author(s): 星野太佑
  • Organizer: 第8回乳酸研究会
  • Place of Presentation: 東京大学 (東京都)
  • Invited
• [Presentation] ジクロロ酢酸摂取による運動中の乳酸濃度の低下が骨格筋のエネルギー代謝の適応に与える影響 (2012)
  • Author(s): 星野太佑,田村優樹,増田紘之,八田秀雄
  • Organizer: 第67回日本体力医学会大会
  • Place of Presentation: 長良川国際会議場(岐阜)
  • Year and Date: 2012-09-15
• [Presentation] Effects of dichloroacetate administration on training-induced metabolic adaptation (2012)
  • Author(s): Daisuke Hoshino, Yuki Tamura, Hiroyuki Masuda, Hideo Hatta
  • Organizer: 15th International Biochemistry of Exercise Congress
  • Place of Presentation: The Swedish School of Sport and HealthSciences (Sweden)
  • Year and Date: 2012-06-20
• [Presentation] 高強度トレーニングによる骨格筋エネルギー代謝の適応 (2012)
  • Author(s): 星野太佑
  • Organizer: 第8回乳酸研究会
  • Place of Presentation: 東京大学(東京都)(招待講演)
  • Year and Date: 2012-02-18
• [Presentation] ジクロロ酢酸摂取による運動中の乳酸濃度の低下が骨格筋のエネルギー代謝の適応に与える影響 (2012)
  • Author(s): 星野太佑, 田村優樹, 増田紘之, 八田秀雄
  • Organizer: 第67回日本体力医学会大会
  • Place of Presentation: 長良川国際会議場 (岐阜県岐阜市)
• [Presentation] Effects of dichloroacetate administration on training-induced metabolic adaptation (2012)
  • Author(s): Daisuke Hoshino, Yuki Tamura, Hiroyuki Masuda, Hideo Hatta
  • Organizer: 15th International Biochemistry of Exercise Congress
  • Place of Presentation: スウェーデン王立大学 (スウェーデン)
• [Presentation] High-intensity interval training increases the rate of mitochondrial fatty acid oxidation in rat skeletal muscle (2011)
  • Author(s): Daisuke Hoshino, Yuko Yoshida, Hideo Hatta
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 海峡メッセ下関(山口県)
  • Year and Date: 2011-09-17