Analysis and risk assessment of intestinal inflammation induced by food-containing nanoparticles.
| Project/Area Number |
23890082
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|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Hygiene
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| Research Institution | Mie University |
|---|
Principal Investigator |
OIKAWA Saeko (TADA Saeko) 三重大学, 地域イノベーション学研究科, 特任助教 (90610585)
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|---|
| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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|---|
| Keywords | ナノ粒子 / 二酸化チタン / 酸化亜鉛 / 炎症 / 二酸化ケイ素 / 大腸炎 / 腸管免疫機構 / 炎症性腸疾患 |
|---|
| Research Abstract |
The present study investigated the cytotoxicity, production of reactive oxygen species (ROS) and inflammatory cytokine induced by nano-TiO2 and nano-ZnO particles using human monocytic leukemia cells (THP-1) and human colon cancer cells (Caco-2). The viability of THP-1 macrophages exposed to nano-ZnO was lower than that to nano-TiO2 THP-1. The production of ROS and IL-1βshowed a tendency to be increased by nano-TiO2 particles. This study indicated that nano-TiO2 particles may induce inflammation in THP-1 macrophages through production of ROS and IL-1β, and nano- ZnO particles were suggested to be more toxic to THP-1 macrophages than nano-TiO_2 .
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat.2012
Author(s)
Chang J, Oikawa S, Ichihara G, Nanpei Y, Hotta Y, Yamada Y, Tada-Oikawa S, Iwahashi H, Kitagawa E, Takeuchi I, Yuda M, Ichihara S.
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Journal Title
Nutr Metab (Lond).
Volume: 9（1）
Issue: 1
Pages: 87-87
DOI
NAID
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Peer Reviewed
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[Presentation] Dispersion method for safety research on manufactured nanomaterials2012
Author(s)
Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, Sahoko Ichihara
Organizer
第40回産業中毒・生物学的モニタリング研究会
Place of Presentation
東京
Year and Date
2012-11-16
Related Report
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[Presentation] Dispersion Method for Safety Researches on Manufactured Nanomaterials2012
Author(s)
Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, Sahoko Ichihara
Organizer
International Union of Materials Research societies-International Union of Materials Research societies-International Conference on Electronic Materials 2012
Place of Presentation
Yokohama
Year and Date
2012-09-26
Related Report
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[Presentation] Dispersion method for safety research on manufactured nanomaterials2012
Author(s)
Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, Sahoko Ichihara
Organizer
The 6th International Conference on Nanotoxicology
Place of Presentation
Beijing, China
Year and Date
2012-09-05
Related Report
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