The role of Kruppel-like Factor 4 (KLF4)in glomerular podocytes and its application to the therapy of proteinuria.
Project/Area Number |
23890205
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Kidney internal medicine
|
Research Institution | Keio University |
Principal Investigator |
HAYASHI Kaori 慶應義塾大学, 医学部, 助教 (60445294)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 腎臓 / 高血圧 / 糸球体上皮細胞 / 糸球体上皮細胞(ポドサイト) / KLF4 / ネフリン |
Research Abstract |
KLF4 is expressed in kidney glomerular epithelial cells (podocytes), and its expression is decreased in proteinuric states. Transient restoration of decreased podocyte KLF4 by transgenic expression or gene transfer inducedepithelial phenotype of podocytes
|
Report
(3 results)
Research Products
(18 results)