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Antioxidant property of anodically oxidized titanium

Research Project

Project/Area Number 23890208
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Dental engineering/Regenerative dentistry
Research InstitutionShowa University

Principal Investigator

MURAKAMI Asuka  昭和大学, 歯学部, 兼任講師 (70611218)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsチタン / インプラント / 創傷治癒 / 酸化ストレス / 表面処理
Research Abstract

Cells adhering onto implant surfaces are subjected to oxidative stress during wound healing processes. Although titanium and its alloys are among the most frequently used biomaterials in orthopedic and dental implants, titanium surfaces do not have antioxidant properties, and cells grown on these surfaces can show permanent oxidative stress. The present study assessed the antioxidant property and osteogenic properties of titanium samples with or without oxidation treatments. A thick rutile TiO_2 film was observed on thermally oxidized titanium surfaces, while amorphous anatase TiO_2 formed on anodically oxidized titanium surfaces prepared by discharging in 1 M Na_2HPO_4. A resistance to the depletion of reduced glutathione in adherent osteoblasts, which correlates withantioxidant behavior, occurred on anodically oxidized titanium. Enhanced osteogenic gene expressions and nano-biomechanical properties of mineralized tissue were achieved on anodically oxidized titanium, in comparison with thermally oxidized or untreated titanium. Thus, anodic oxidation by discharging in electrolyte is expected to be a useful surface modification for titanium implants.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (3 results)

All 2012

All Journal Article (3 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Antimicrobial and osteogenic properties of ahydrophilic-modified nanoscale hydroxyapatite coating on titanium2012

    • Author(s)
      Murakami A., Arimoto T., Suzuki D.,Iwai-Yoshida M., Otsuka F., Shibata Y., Igarashi T., Kamijo R. and Miyazaki T
    • Journal Title

      Nanomedicine: Nanotechnology, Biology and Medicine

      Volume: 8 Pages: 374-382

    • Related Report
      2012 Final Research Report
  • [Journal Article] Antimicrobial and osteogenic properties of a hydrophilic-modified nanoscale hydroxyapatite coating on titanium2012

    • Author(s)
      Murakami A., et al
    • Journal Title

      Nanomedicine

      Volume: 8 Issue: 3 Pages: 374-382

    • DOI

      10.1016/j.nano.2011.07.001

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidant and osteogenic properties of anodically oxidized titanium2012

    • Author(s)
      Iwai-Yoshida M., Shibata Y., Wurihan, Suzuki D., Fujisawa N., Tanimoto Y., Kamijo R., Maki K. and Miyazaki T.
    • Journal Title

      Journal of the Mechanical Behavior of Biomedical Materials

      Volume: (in press) Pages: 230-236

    • DOI

      10.1016/j.jmbbm.2012.01.016

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2011-09-05   Modified: 2019-07-29  

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