Congenital reproductive tract anomalies in altered MYCN/RA axis

• Project/Area Number: 23K05601
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 42040:Laboratory animal science-related
• Research Institution: Nagoya City University
• Principal Investigator: シャウキ ホッサム 名古屋市立大学, 医薬学総合研究院(医学), 助教 (70829738)
• Co-Investigator(Kenkyū-buntansha): 大石 久史 名古屋市立大学, 医薬学総合研究院(医学), 教授 (30375513)
• Project Period (FY): 2023-04-01 – 2026-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2025: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2024: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2023: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: reproductive truct / retinoic acid / mycn

Outline of Research at the Start

Retinoic acid signaling were found to induce the reproductive tract development. We found a patient with MYCN mutation that turn it to be constitutive active. By generating mouse model similar to that patient, the mouse will be analyzed whether the reproductive tract malformation was developed. We also examine that increasing MYCN expression inhibit retinoic acid signaling in the reproductive development and that might cause a genital malformation. In our proposal, we aim to identify the detailed mechanism of MYCN/RA axis during the development of the reproductive tract.