Research Project
Grant-in-Aid for Early-Career Scientists
Osteonecrosis of the Femoral Head (ONFH) is an osteonecrotic condition originated from the inadequate blood supply to bone and has a high rate of disability. Until now the molecular aetiology behind ONFH has not been clarified. This study aims to develop a surgical mouse model for ONFH for the first time in the literature to clarify the molecular mechanisms leading to traumatic ONFH; in purpose of developing a regenerative treatment by transplantation of a specialised endothelial cell side population which can be applicable in clinics