Global Exploration for Redox Supermolecules Evolving in Life Functions

• Project/Area Number: 23K20040
• Research Category: Fund for the Promotion of Joint International Research (International Leading Research )
• Allocation Type: Multi-year Fund
• Review Section: Biological Sciences
• Research Institution: Tohoku University
• Principal Investigator: 赤池 孝章 東北大学, 医学系研究科, 教授 (20231798)
• Co-Investigator(Kenkyū-buntansha): 本橋 ほづみ 東北大学, 医学系研究科, 教授 (00282351) ; 澤 智裕 熊本大学, 大学院生命科学研究部(医), 教授 (30284756) ; 中林 孝和 東北大学, 薬学研究科, 教授 (30311195) ; 斎藤 芳郎 東北大学, 薬学研究科, 教授 (70357060) ; 花岡 健二郎 慶應義塾大学, 薬学部(芝共立), 教授 (70451854) ; 三木 裕明 京都大学, 工学研究科, 教授 (80302602) ; 西田 基宏 九州大学, 薬学研究院, 教授 (90342641) ; 魏 范研 東北大学, 加齢医学研究所, 教授 (90555773) ; 潮田 亮 京都産業大学, 生命科学部, 准教授 (30553367)
• Project Period (FY): 2023-11-17 – 2030-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥689,000,000 (Direct Cost: ¥530,000,000、Indirect Cost: ¥159,000,000); Fiscal Year 2029: ¥92,950,000 (Direct Cost: ¥71,500,000、Indirect Cost: ¥21,450,000); Fiscal Year 2028: ¥92,950,000 (Direct Cost: ¥71,500,000、Indirect Cost: ¥21,450,000); Fiscal Year 2027: ¥92,950,000 (Direct Cost: ¥71,500,000、Indirect Cost: ¥21,450,000); Fiscal Year 2026: ¥92,950,000 (Direct Cost: ¥71,500,000、Indirect Cost: ¥21,450,000); Fiscal Year 2025: ¥92,950,000 (Direct Cost: ¥71,500,000、Indirect Cost: ¥21,450,000); Fiscal Year 2024: ¥92,950,000 (Direct Cost: ¥71,500,000、Indirect Cost: ¥21,450,000); Fiscal Year 2023: ¥131,300,000 (Direct Cost: ¥101,000,000、Indirect Cost: ¥30,300,000)
• Keywords: レドックス超分子 / 超硫黄分子 / 酸化ストレス / レドックス超分子生命科学 / Redox Supermolecules / Global Exploration / Sulfur Biochemistry / Sulfur Biotechnology / Sulfur Medicine

Outline of Research at the Start

本研究事業では、レドックス超分子研究分野において、研究代表者と国内連携拠点の各研究分担者らが築き上げてきたグローバルネットワークの強化と拡張・推進に向けて、緊密な共同研究と人材育成体制を整備・拡大し、長期的な視点からのグローバルな展開を図る。本事業では、長期派遣（2年から3年間）を全期間中15名および短期派遣（3ヶ月）を年間5名予定している。また、短期研修支援として年間15名の若手研究者を海外学会・ワークショップへ派遣することを予定している。本共同研究事業を契機に、これまで世界各国に散在していたグローバルなレドックス超分子の学術体系を融合・深化させた「レドックス超分子生命科学」を創成するものである。

Outline of Annual Research Achievements

近年、レドックス超分子による生命機能制御の視点から生命原理を理解しようとする世界的な潮流が高まってきた。生体内のレドックス超分子は量子すなわち電子エネルギー動態により支配されており、我々はこれを「レドックス超分子の先端科学」という新しい枠組みとして捉えて、国際的な共同研究を精力的に展開してきた。自然界に普遍的に存在する酸素分子や活性分子種[活性酸素や酸化窒素種等]をはじめ、生体内で活発に産生・代謝されている一連の物質を「レドックス超分子(Redox supermolecules)」と総称する。一方、地球の生命進化を牽引してきたもう一つの重要なレドックス超分子として、超硫黄分子が挙げられる。最近の国際共同研究により、世界ではじめて、単一の硫黄が連鎖した超硫黄分子が生物種普遍的に大量に産生され、エネルギー代謝や酸化ストレス制御などの多彩な生命現象に関わることが分かってきた。本研究事業では、研究代表者と国内連携拠点の各研究分担者らが築き上げてきた、レドックス超分子研究分野におけるグローバルネットワークの強化と拡張・推進に向けて、緊密な共同研究と人材育成体制を整備・拡大し、画期的な視点からのグローバルな展開を図る。当該事業推進を契機に、これまで世界各国に散在していたグローバルなレドックス超分子の学術体系を融合・深化させた「レドックス超分子生命科学」を創成するものである。このことにより世界規模の研究共創を学術と若手人材育成の観点から俯瞰し戦略的に推進することで、生命科学のみならず基礎および臨床医学さらには人類の健康福祉の向上に大きく貢献することが期待される。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

初年に本学のレドックス研究拠点に設置したリエゾンオフィスを介して、海外の著名なレドックス研究者を招聘し、第２回国際シンポジウムを開催した。５名の大学院博士課程と若手研究者を５箇所の海外研究施設に短期派遣し、１５名の若手研究者の海外研修を実施した。そのうち大学院博士課程４年で米国ダナファーバー研究所に派遣した１名は２０２４年度の育志賞を受賞し、来年度から米国同研究所における長期派遣に移行する予定である。

Strategy for Future Research Activity

当該事業の当初目的に照らして、研究遂行の上での問題はなく順調に研究が進展している。引き続き、国内拠点メンバーによる大学院生やポスドクの海外派遣や研修、共同研究を管理・運営することにより、レドックス超分子研究の卓越した若手人材育成を強力に推進する。

Research Products

• [Int'l Joint Research] MPI-P Mainz/German Cancer Research Center/Helmholtz Munich(ドイツ)
• [Int'l Joint Research] National Institute of Oncology(ハンガリー)
• [Int'l Joint Research] University of California/Brown University/University of Vermont(米国)
• [Int'l Joint Research] University of Birmingham(英国)
• [Int'l Joint Research] IISER Pune(インド)
• [Int'l Joint Research] German Cancer Research Center/Helmholtz(ドイツ)
• [Int'l Joint Research] National Institute of Oncology(ハンガリー)
• [Int'l Joint Research] University of Vermont/Brown University(米国)
• [Int'l Joint Research] Birmingham(英国)
• [Journal Article] Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis (2025)
  • Author(s): Morishima, T., Fakruddin, M., Kanamori, Y., Masuda, T., Ogawa, A., Wang, Y., Schoonenberg, V. A. C., Butter, F., Arima, Y., Akaike, T., Moroishi, T., Tomizawa, K., Suda, T., Wei, F. Y., & Takizawa, H.
  • Journal Title: Science advances Volume: 11 Issue: 8 Pages: 1-17
  • DOI: 10.1126/sciadv.adu3011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases (2025)
  • Author(s): Zhang Tianli、Toyomoto Touya、Sawa Tomohiro、Akaike Takaaki、Matsunaga Tetsuro
  • Journal Title: Microbiology and Immunology Volume: 69 Issue: 4 Pages: 191-202
  • DOI: 10.1111/1348-0421.13205
  • Peer Reviewed / Open Access
• [Journal Article] Supersulfides contribute to joint homeostasis and bone regeneration. (2025)
  • Author(s): Maemura M, Morita M, Ogata S, Miyamoto Y, Ida T, Shibusaka K, Negishi S, Hosonuma M, Saito T, Yoshitake J, Takata T, Matsunaga T, Mishima E, Barayeu U, Akaike T, Yano F.
  • Journal Title: Redox Biol. Volume: 81 Pages: 103545-103545
  • DOI: 10.1016/j.redox.2025.103545
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Supersulfide metabolome of exhaled breath condensate applied as diagnostic biomarkers for esophageal cancer (2025)
  • Author(s): Asamitsu Seji、Ozawa Yohei、Okamoto Hiroshi、Ogata Seiryo、Matsunaga Tetsuro、Yoshitake Jun、Fusegawa Kazuki、Taniyama Yusuke、Sato Chiaki、Ishida Hirotaka、Abe Takaaki、Motohashi Hozumi、Akaike Takaaki、Kamei Takashi
  • Journal Title: Cancer Science Volume: - Issue: 4 Pages: 1023-1033
  • DOI: 10.1111/cas.16430
  • Peer Reviewed / Open Access
• [Journal Article] Non-thermal atmospheric pressure plasma-irradiated cysteine protects cardiac ischemia/reperfusion injury by preserving supersulfides. (2025)
  • Author(s): Nishimura A, Tanaka T, Shimoda K, Ida T, Sasaki S, Umezawa K, Imamura H, Urano Y, Ichinose F, Kaneko T, Akaike T, Nishida M
  • Journal Title: Redox Biology Volume: 79:103445 Pages: 1-14
  • DOI: 10.1016/j.redox.2024.103445
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Therapeutic Potential of Supersulfides in Oxidative Stress-Related Diseases (2025)
  • Author(s): Pan Yuexuan、Matsunaga Tetsuro、Zhang Tianli、Akaike Takaaki
  • Journal Title: Biomolecules Volume: 15 Issue: 2 Pages: 172-172
  • DOI: 10.3390/biom15020172
  • Peer Reviewed / Open Access
• [Journal Article] Polysulfur-based bulking of dynamin-related protein 1 prevents 1 ischemic sulfide catabolism and heart failure in mice. (2025)
  • Author(s): Nishimura A, Ogata S, Tang X, Hengphasatporn K, Umezawa K, Sanbo M, Hirabayashi M, Kato Y, Ibuki Y, Kumagai Y, Kobayashi K, Urano Y, , Shigeta Y, Akaike T, Nishida M
  • Journal Title: Nature Communications Volume: 16:276 Issue: 1 Pages: 1-17
  • DOI: 10.1038/s41467-024-55661-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phototriggered Hydrogen Persulfide Donors via Hydrosulfide Radical Formation Enhancing the Reactive Sulfur Metabolome in Cells. (2024)
  • Author(s): Roy B, Shieh M, Takata T, Jung M, Das E, Xu S, Akaike T, Xian M.
  • Journal Title: J Am Chem Soc. Volume: 146 Issue: 44 Pages: 30502-30509
  • DOI: 10.1021/jacs.4c11540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inorganic sulfides prevent osimertinib-induced mitochondrial dysfunction in human iPS cell-derived cardiomyocytes (2024)
  • Author(s): Kondo M, Nakamura Y, Kato Y, Nishimura A, Fukata M, Moriyama S, Ito T, Umezawa K, Urano Y, Akaike T, Akashi K, Kanda Y, Nishida M
  • Journal Title: Journal of Pharmacological Science Volume: 156:2 Issue: 2 Pages: 69-76
  • DOI: 10.1016/j.jphs.2024.07.007
  • Peer Reviewed / Open Access
• [Journal Article] Supersulfide formation in the sinus mucosa of chronic rhinosinusitis. (2024)
  • Author(s): Suzuki J, Hemmi T, Ida T, Ogata S, Yoshitake J, Matsunaga T, Ishida T, Numano Y, Kusano Y, Ikeda R, Nomura K, Sugawara M, Ohta N, Akaike T, Katori Y.
  • Journal Title: Laryngoscope Investig Otolaryngol Volume: 9 Issue: 4
  • DOI: 10.1002/lio2.1261
  • Peer Reviewed / Open Access
• [Journal Article] New aspects of redox signaling mediated by supersulfides in health and disease (2024)
  • Author(s): Akaike Takaaki、Morita Masanobu、Ogata Seiryo、Yoshitake Jun、Jung Minkyung、Sekine Hiroki、Motohashi Hozumi、Barayeu Uladzimir、Matsunaga Tetsuro
  • Journal Title: Free Radical Biology and Medicine Volume: 222 Pages: 539-551
  • DOI: 10.1016/j.freeradbiomed.2024.07.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Deciphering pathophysiological mechanisms underlying cystathionine beta-synthase-deficient homocystinuria using targeted metabolomics, liver proteomics, sphingolipidomics and analysis of mitochondrial function (2024)
  • Author(s): Majtan Tomas、Olsen Thomas、Sokolova Jitka、Krijt Jakub、Krizkova Michaela、Ida Tomoaki、Ditroi Tamas、Hansikova Hana、Vit Ondrej、Petrak Jiri、Kuchar Ladislav、Kruger Warren D.、Nagy Peter、Akaike Takaaki、Kozich Viktor
  • Journal Title: Redox Biology Volume: 73 Pages: 103222-103222
  • DOI: 10.1016/j.redox.2024.103222
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity (2024)
  • Author(s): Sekine H, Takeda H, Takeda N, Kishino A, Anzawa H, Isagawa T, Ohta N, Murakami S, Iwaki H, Kato N, Kimura S, Liu Z, Kato K, Katsuoka F, Yamamoto M, Miura F, Ito T, Takahashi M, Izumi Y, Fujita H, Yamagata H, Bamba T, Akaike T, Suzuki N, Kinoshita K, Motohashi H
  • Journal Title: Nature Metabolism Volume: 6 Issue: 6 Pages: 1108-1127
  • DOI: 10.1038/s42255-024-01053-4
  • Peer Reviewed / Open Access
• [Journal Article] PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis (2024)
  • Author(s): 2.Fujita H., Tanaka Y., Ogata S., Suzuki N., Kuno S., Barayeu U., Akaike T., Ogra Y. and Iwai K.
  • Journal Title: Nature structural & molecular biology Volume: 31 Issue: 8 Pages: 1277-1285
  • DOI: 10.1038/s41594-024-01329-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Supersulfide catabolism participates in maladaptive remodeling of cardiac cells (2024)
  • Author(s): Zhou L, Nishimura A, Umezawa K, Kato Y, Mi X, Ito T, Urano Y, Akaike T, Nishida M
  • Journal Title: Journal of Pharmacological Science Volume: 155:4 Issue: 4 Pages: 121-130
  • DOI: 10.1016/j.jphs.2024.05.002
  • Peer Reviewed / Open Access
• [Journal Article] Exclusion of sulfide:quinone oxidoreductase from mitochondria causes Leigh-like disease in mice by impairing sulfide metabolism (2024)
  • Author(s): Kanemaru Eiki、Shimoda Kakeru、Marutani Eizo、Morita Masanobu、Miranda Maria、Miyazaki Yusuke、Sinow Claire、Sharma Rohit、Dong Fangcong、Bloch Donald B.、Akaike Takaaki、Ichinose Fumito
  • Journal Title: Journal of Clinical Investigation Volume: 134 Issue: 15
  • DOI: 10.1172/jci170994
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides (2024)
  • Author(s): Hirai Takeru、Ikeda-Imafuku Mayumi、Tasaka Nanami、Chuang Victor Tuan Giam、Xian Ming、Ishida Tatsuhiro、Akaike Takaaki、Ishima Yu
  • Journal Title: Advances in Redox Research Volume: 10 Pages: 100091-100091
  • DOI: 10.1016/j.arres.2023.100091
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Redox regulation of xenobiotics by reactive sulfur and supersulfide species (2024)
  • Author(s): Zhang Tianli、Akaike Takaaki、Sawa Tomohiro
  • Journal Title: Antioxidants Redox Signaling Volume: 40 Issue: 10-12 Pages: 679-690
  • DOI: 10.1089/ars.2022.0172
  • Peer Reviewed / Open Access
• [Journal Article] 2H-Thiopyran-2-thione sulfine, a compound for converting H2S to HSOH/H2S2 and increasing intracellular sulfane sulfur levels (2024)
  • Author(s): Cui Qi、Shieh Meg、Pan Tony W.、Nishimura Akiyuki、Matsunaga Tetsuro、Kelly Shane S.、Xu Shi、Jung Minkyung、Ogata Seiryo、Morita Masanobu、Yoshitake Jun、Chen Xiaoyan、Robinson Jerome R.、Qian Wei-Jun、Nishida Motohiro、Akaike Takaaki、Xian Ming
  • Journal Title: Nature Communications Volume: 15 Issue: 1 Pages: 2453-2453
  • DOI: 10.1038/s41467-024-46652-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Essential role of ROS - 8-Nitro-cGMP signaling in long-term memory of motor learning and cerebellar synaptic plasticity (2024)
  • Author(s): Kakizawa Sho、Arasaki Tomoko、Yoshida Ayano、Sato Ayami、Takino Yuka、Ishigami Akihito、Akaike Takaaki、Yanai Shuichi、Endo Shogo
  • Journal Title: Redox Biology Volume: 70 Pages: 103053-103053
  • DOI: 10.1016/j.redox.2024.103053
  • Peer Reviewed / Open Access
• [Journal Article] Regulation of innate immune and inflammatory responses by supersulfides (2024)
  • Author(s): Tsutsuki Hiroyasu、Zhang Tianli、Akaike Takaaki、Sawa Tomohiro
  • Journal Title: International Immunology Volume: 36 Issue: 4 Pages: 143-154
  • DOI: 10.1093/intimm/dxad057
  • Peer Reviewed / Open Access
• [Journal Article] Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality (2024)
  • Author(s): Nishimura Akira、Yoon Sunghyeon、Matsunaga Tetsuro、Ida Tomoaki、Jung Minkyung、Ogata Seiryo、Morita Masanobu、Yoshitake Jun、Unno Yuka、Barayeu Uladzimir、Takata Tsuyoshi、Takagi Hiroshi、Motohashi Hozumi、van der Vliet Albert、Akaike Takaaki
  • Journal Title: Redox Biology Volume: 69 Pages: 103018-103018
  • DOI: 10.1016/j.redox.2023.103018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quantitative profiling of supersulfides naturally occurring in dietary meats and beans (2024)
  • Author(s): Kasamatsu Shingo、Kinno Ayaka、Miura Chiharu、Hishiyama Jun-ichi、Fukui Kensuke、Kure Shoji、Tsumura Kazunobu、Ida Tomoaki、Matsunaga Tetsuro、Akaike Takaaki、Ihara Hideshi
  • Journal Title: Analytical Biochemistry Volume: 685 Pages: 115392-115392
  • DOI: 10.1016/j.ab.2023.115392
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Supersulfides support bone growth by promoting chondrocyte proliferation in the growth plates (2024)
  • Author(s): Sasama Yuji、Yoshimura Kentaro、Hoshino Marie、Sasa Kiyohito、Akaike Takaaki、Morita Masanobu、Baba Kazuyoshi、Shirota Tatsuo、Miyamoto Yoichi
  • Journal Title: Journal of Oral Biosciences Volume: 66 Issue: 1 Pages: 76-81
  • DOI: 10.1016/j.job.2023.11.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Alkyl gallates inhibit serine O-acetyltransferase in bacteria and enhance susceptibility of drug-resistant Gram-negative bacteria to antibiotics (2023)
  • Author(s): Toyomoto Touya、Ono Katsuhiko、Shiba Tomoo、Momitani Kenta、Zhang Tianli、Tsutsuki Hiroyasu、Ishikawa Takeshi、Hoso Kanae、Hamada Koma、Rahman Azizur、Wen Liping、Maeda Yosuke、Yamamoto Keiichi、Matsuoka Masao、Hanaoka Kenjiro、Niidome Takuro、Akaike Takaaki、Sawa Tomohiro
  • Journal Title: Frontiers in Microbiology Volume: 14 Pages: 1276447-1276447
  • DOI: 10.3389/fmicb.2023.1276447
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Supersulfide biology and translational medicine for disease control (2023)
  • Author(s): Barayeu Uladzimir、Sawa Tomohiro、Nishida Motohiro、Wei Fan-Yan、Motohashi Hozumi、Akaike Takaaki
  • Journal Title: British Journal of Pharmacology Volume: - Issue: 1 Pages: 1-11
  • DOI: 10.1111/bph.16271
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Untargeted polysulfide omics analysis of alternations in polysulfide production during the germination of broccoli sprouts (2023)
  • Author(s): Kasamatsu Shingo、Owaki Takuma、Komae Somei、Kinno Ayaka、Ida Tomoaki、Akaike Takaaki、Ihara Hideshi
  • Journal Title: Redox Biology Volume: 67 Pages: 102875-102875
  • DOI: 10.1016/j.redox.2023.102875
  • Peer Reviewed / Open Access
• [Journal Article] Hypoxic erythrocytes mediate cardioprotection through activation of soluble guanylate cyclase and release of cyclic GMP (2023)
  • Author(s): Yang Jiangning、Sundqvist Michaela L.、Zheng Xiaowei、Jiao Tong、Collado Aida、Tratsiakovich Yahor、Mahdi Ali、Tengbom John、Mergia Evanthia、Catrina Sergiu-Bogdan、Zhou Zhichao、Carlstrom Mattias、Akaike Takaaki、Cortese-Krott Miriam M.、Weitzberg Eddie、Lundberg Jon O.、Pernow John
  • Journal Title: Journal of Clinical Investigation Volume: 133 Issue: 17
  • DOI: 10.1172/jci167693
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Persulfide biosynthesis conserved evolutionarily in all organisms (2023)
  • Author(s): Ogata Seiryo、Matsunaga Tetsuro、Jung Minkyung、Barayeu Uladzimir、Morita Masanobu、Akaike Takaaki
  • Journal Title: Antioxidants Redox Signaling Volume: 39 Issue: 13-15 Pages: 983-999
  • DOI: 10.1089/ars.2023.0405
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Supersulfide catalysis for nitric oxide and aldehyde metabolism (2023)
  • Author(s): Kasamatsu Shingo、Nishimura Akira、Alam Md. Morshedul、Morita Masanobu、Shimoda Kakeru、Matsunaga Tetsuro、Jung Minkyung、Ogata Seiryo、Barayeu Uladzimir、Ida Tomoaki、Nishida Motohiro、Nishimura Akiyuki、Motohashi Hozumi、Akaike Takaaki
  • Journal Title: Science Advances Volume: 9 Issue: 33 Pages: 1-11
  • DOI: 10.1126/sciadv.adg8631
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop. (2023)
  • Author(s): Takeda H, Murakami S, Liu Z, Sawa T, Takahashi M, Izumi Y, Bamba T, Sato H, Akaike T, Sekine H, Motohashi H*.
  • Journal Title: Redox Biology Volume: 65 Pages: 102834-102834
  • DOI: 10.1016/j.redox.2023.102834
  • Peer Reviewed / Open Access
• [Journal Article] Supersulphides provide airway protection in viral and chronic lung diseases (2023)
  • Author(s): Matsunaga Tetsuro、Sano Hirohito、Takita Katsuya、Morita Masanobu、Yamanaka Shun、Ichikawa Tomohiro、Numakura Tadahisa、Ida Tomoaki、Jung Minkyung、Ogata Seiryo、Yoon Sunghyeon、Fujino Naoya、Kyogoku Yorihiko、Akaike Takaaki、et al.
  • Journal Title: Nature Communications Volume: 14 Issue: 1 Pages: 4476-4476
  • DOI: 10.1038/s41467-023-40182-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glutathione trisulfide prevents lipopolysaccharide-induced retinal inflammation via inhibition of proinflammatory cytokine production in glial cells (2023)
  • Author(s): Tawarayama Hiroshi、Umeki Kota、Inoue-Yanagimachi Maki、Takahashi Naoki、Hasegawa Hirokazu、Himori Noriko、Tsuda Satoru、Kunikata Hiroshi、Akaike Takaaki、Nakazawa Toru
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 11513-11513
  • DOI: 10.1038/s41598-023-38696-4
  • Peer Reviewed / Open Access
• [Journal Article] Development of methods for quantitative determination of the total and reactive polysulfides: Reactive polysulfide profiling in vegetables (2023)
  • Author(s): Kasamatsu Shingo、Kinno Ayaka、Hishiyama Jun-ichi、Akaike Takaaki、Hideshi IharaIhara Hideshi
  • Journal Title: Food Chemistry Volume: 413 Pages: 135610-135610
  • DOI: 10.1016/j.foodchem.2023.135610
  • Peer Reviewed / Open Access
• [Journal Article] Presence of <i>Helicobacter cinaedi</i> in Atherosclerotic Abdominal Aortic Aneurysmal Wall (2023)
  • Author(s): Horii Shinichiro、Sugawara Hirofumi、Goto Hitoshi、Hashimoto Munetaka、Matsunaga Tetsuro、Akamatsu Daijirou、Tajima Yuta、Umetsu Michihisa、Akaike Takaaki、Kamei Takashi
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 261 Issue: 1 Pages: 35-41
  • DOI: 10.1620/tjem.2023.J049
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cystathionine γ-lyase self-inactivates by polysulfidation during cystine metabolism (2023)
  • Author(s): Araki Shoma、Takata Tsuyoshi、Ono Katsuhiko、Sawa Tomohiro、Kasamatsu Shingo、Ihara Hideshi、Kumagai Yoshito、Akaike Takaaki、Watanabe Yasuo、Tsuchiya Yukihiro
  • Journal Title: International Journal of Molecular Sciences Volume: 24 Issue: 12 Pages: 9982-9982
  • DOI: 10.3390/ijms24129982
  • Peer Reviewed / Open Access
• [Journal Article] Reactive sulfur species omics analysis in the brain tissue of the 5xFAD mouse model of Alzheimer’s disease (2023)
  • Author(s): Kinno Ayaka、Kasamatsu Shingo、Akaike Takaaki、Ihara Hideshi
  • Journal Title: Antioxidants Volume: 12 Issue: 5 Pages: 1105-1105
  • DOI: 10.3390/antiox12051105
  • Peer Reviewed / Open Access
• [Journal Article] Synthesis of sulfides and persulfides is not impeded by disruption of three canonical enzymes in sulfur metabolism (2023)
  • Author(s): Zainol Abidin Qamarul Hafiz、Ida Tomoaki、Morita Masanobu、Matsunaga Tetsuro、Nishimura Akira、Jung Minkyung、Hassan Naim、Takata Tsuyoshi、Ishii Isao、Kruger Warren、Wang Rui、Motohashi Hozumi、Tsutsui Masato、Akaike Takaaki
  • Journal Title: Antioxidants Volume: 12 Issue: 4 Pages: 868-868
  • DOI: 10.3390/antiox12040868
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] レドックス生命科学の国際先導研究:超硫黄の巨大潮流 (2024)
  • Author(s): 赤池孝章
  • Organizer: 日本酸化ストレス学会・日本NO学会 (横須賀)
  • Invited
• [Presentation] Redox signaling and metabolism regulated by supersulfides (2024)
  • Author(s): Takaaki Akaike
  • Organizer: The 7th World Congress on Hydrogen Sulfide in Biology and Medicine (Baltimore, USA)
  • Int'l Joint Research
• [Presentation] 超硫黄生物学の新たな展開：超硫黄医療と社会実装 (2024)
  • Author(s): 赤池孝章
  • Organizer: 第40回 日本DDS学会学術集会 (筑波)
  • Invited
• [Presentation] 生体内超硫黄分子の発見と生理機能の解明 (2024)
  • Author(s): 赤池孝章
  • Organizer: フリーラジカルスクール2024（岐阜）
  • Invited
• [Presentation] Metabolism and redox signal regulation by supersulfides (2024)
  • Author(s): Takaaki Akaike
  • Organizer: 3RD INTERNATIONAL CONFERENCE ON PLANT AND HUMAN SULFUR BIOLOGY (Pont-a-Mousson, France)
  • Int'l Joint Research / Invited
• [Presentation] Redox Signal Reguration by Supersulfides (2024)
  • Author(s): Takaaki Akaike
  • Organizer: The 11th Biennial Meeting of Society for Free Radical Research- Asia (Beijing, China)
  • Int'l Joint Research / Invited
• [Presentation] 超硫黄代謝シグナル研究の新展開 (2024)
  • Author(s): 赤池孝章
  • Organizer: 第37回日本酸化ストレス学会関東支部会 (東京)
  • Invited
• [Presentation] Sulfur Biology in Cell Metabolism (2024)
  • Author(s): Takaaki Akaike
  • Organizer: Society for Redox Biology and Medicine’s (SfRBM) 31st Annual Conference (Savannah, USA）
  • Int'l Joint Research / Invited
• [Presentation] Supersulfide redox biology in life science and its translational medicine for disease control (2024)
  • Author(s): Takaaki Akaike
  • Organizer: International Symposium “Signals for Human, Animal and Planetary Health: From Metabolites To Biological Interactions” (Tokyo Univ.)
  • Int'l Joint Research / Invited
• [Presentation] 超硫黄分子のラマン分光イメージングを駆使した定量分析 (2023)
  • Author(s): 赤池 孝章
  • Organizer: CREST「多細胞」領域，第5回領域会議プログラム・連携課題（浜松）
  • Invited
• [Presentation] Supersulfides-mediated cellular protection from lipid oxidation and ferroptosis (2023)
  • Author(s): Takaaki Akaike
  • Organizer: 3rd Annual Meeting of the DFG founded Priority Programme (Heidelberg, Germany)
  • Int'l Joint Research / Invited
• [Presentation] 超硫黄分子の発見と生理機能の解明 (2023)
  • Author(s): 赤池孝章
  • Organizer: 第96回日本生化学会大会・特別講演 (福岡)
  • Invited
• [Presentation] 定量的超硫黄オミックス・イメージング技術の開発と標準化プロトコールの確立 (2023)
  • Author(s): 赤池 孝章
  • Organizer: 学術変革領域研究(A) 「硫黄生物学」第3回領域会議・超硫黄フロンティアシンポジウム2023（熊本）
• [Presentation] Supersulfide biology and translational medicine for disease control (2023)
  • Author(s): Takaaki Akaike
  • Organizer: Chemical Biology/Redox Biology Seminar (Rhode Island, USA)
  • Int'l Joint Research / Invited
• [Presentation] 超硫黄分子によるエネルギー産生と過酸化脂質・カルボニル代謝制御 (2023)
  • Author(s): 赤池孝章
  • Organizer: 名古屋大学大学院生命農学研究科・特別セミナー（名古屋）
  • Invited
• [Book] 呼吸器疾患最新の治療2025-2026（超硫黄分子による呼吸器疾患制御と呼気オミックス） (2024)
  • Author(s): 緒方星陵, 松永哲郎, 赤池孝章
  • Total Pages: 6
  • Publisher: 南江堂
• [Book] 酸化ストレスの医学 改訂第３版（超硫黄分子の化学と生理機能） (2024)
  • Author(s): 緒方星陵, Uladzimir Barayeu, 赤池孝章
  • Total Pages: 7
  • Publisher: 診断と治療社
• [Remarks] 東北大学大学院医学系研究科環境医学分野ホームページ
  • URL: http://www.toxicosci.med.tohoku.ac.jp/index.html
• [Remarks] Research Mapマイポータル
  • URL: https://researchmap.jp/AkaikeT
• [Remarks] 島津製作所×東北大学 超硫黄生命科学共創研究所
  • URL: https://www.shimadzu.co.jp/research_and_development/tohoku-lab/
• [Remarks] 健康寿命を延ばすカギは「老化」のコントロール？ 人生100年時代のヘルスケア
  • URL: https://www.shimadzu.co.jp/today/20240520-1.html
• [Remarks] 「島津製作所×東北大学 超硫黄生命科学共創研究所」を設置
  • URL: https://www.tohoku.ac.jp/japanese/2024/03/press20240313-04-shimazu.html
• [Remarks] 「超硫黄分子」の寿命延長効果を発見 ～新たなサプリメントや健康法の開発に期待～
  • URL: https://www.tohoku.ac.jp/japanese/2024/01/press20240119-01-supersulfides.html
• [Patent(Industrial Property Rights)] 疾患の診断のための硫黄化合物測定方法 (2024)
  • Inventor(s): 山口亮、青野佑亮、赤池孝章
  • Industrial Property Rights Holder: 山口亮、青野佑亮、赤池孝章
  • Industrial Property Rights Type: 特許
  • Filing Date: 2024
• [Funded Workshop] The 2nd International G-ReXS Conference in Sendai (2024)
• [Funded Workshop] The 1st International G-ReXS Conference in Sendai (2024)