| Project/Area Number |
24225005
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
板東 俊和 京都大学, 理学(系)研究科(研究院), 准教授 (20345284)
遠藤 政幸 京都大学, 学内共同利用施設等, 准教授 (70335389)
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| Co-Investigator(Renkei-kenkyūsha) |
ARIVAZHAGAN RAJENDRAN 京都大学, 大学院理学研究科, 研究員 (90723122)
Suzuki Yuki 京都大学, 大学院理学研究科, 研究員 (50636066)
NAMASIVAYAN Ganesh Pandian 京都大学, 物質-細胞統合システム拠点, 特定研究員 (20625446)
SATO Shinsuke 京都大学, 大学院理学研究科, 特定職員
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| Research Collaborator |
HIDAKA Kumi
EMURA Tomoko
HASHIYA Kaori
Taylor Rhys D.
KAWAMOTO Yusuke
ASAMITSU Sefan
TANIGUCHI Junichi
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| Project Period (FY) |
2012-05-31 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥212,810,000 (Direct Cost: ¥163,700,000、Indirect Cost: ¥49,110,000)
Fiscal Year 2016: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2015: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2014: ¥56,810,000 (Direct Cost: ¥43,700,000、Indirect Cost: ¥13,110,000)
Fiscal Year 2013: ¥64,480,000 (Direct Cost: ¥49,600,000、Indirect Cost: ¥14,880,000)
Fiscal Year 2012: ¥39,260,000 (Direct Cost: ¥30,200,000、Indirect Cost: ¥9,060,000)
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| Keywords | 遺伝子発現制御 / エピジェネティックス / 細胞初期化 / Py-Imポリアミド / DNAナノ構造体 / 遺伝子発現 / 初期化 / エピジェネティクス |
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| Outline of Final Research Achievements |
The regulating methodologies of epigenetic gene expression were developed by using functional Py-Im polyamide conjugates in our laboratory. In addition, dynamic motions for one molecule level were directly visualized by using DNA frame technologies with atomic force microscope (AFM). By the combination with these chemical biology researches,we would realize to elucidate the mechanism of specific gene expression through the chemical approach based on DNA structures and functions.
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| Assessment Rating |
Verification Result (Rating)
A+
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Assessment Rating |
Result (Rating)
A+: Progress in the research exceeds the initial goal. More than expected research results are expected.
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