Budget Amount *help |
¥217,880,000 (Direct Cost: ¥167,600,000、Indirect Cost: ¥50,280,000)
Fiscal Year 2016: ¥31,460,000 (Direct Cost: ¥24,200,000、Indirect Cost: ¥7,260,000)
Fiscal Year 2015: ¥31,720,000 (Direct Cost: ¥24,400,000、Indirect Cost: ¥7,320,000)
Fiscal Year 2014: ¥31,720,000 (Direct Cost: ¥24,400,000、Indirect Cost: ¥7,320,000)
Fiscal Year 2013: ¥46,020,000 (Direct Cost: ¥35,400,000、Indirect Cost: ¥10,620,000)
Fiscal Year 2012: ¥76,960,000 (Direct Cost: ¥59,200,000、Indirect Cost: ¥17,760,000)
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Outline of Final Research Achievements |
Regarding ion channel, we solved high-resolution crystal structures of newly-identified Mg2+ channel MgtE, TRIC channel, P2X channel, and elucidated their substrate recognition mechanisms and gating mechanisms. For membrane transporters, we solved high-resolution crystal structures of Ca2+/H+ exchanger CAX, Fe2+ exporter FPN, sugar transporter SWEET, peptide transporter POT, amino acid exporter YddG, multi-drug exporter MATE, membrane protein integrator YidC to elucidate their substrate recognition mechanisms and transport mechanisms. We also solved high-resolution crystal structures of channel rhodopsin and light-driven Na+-pump KR2, which suggested how these rhodopsin channel/pump are gated upon light perception.
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