SCN-Gene-Project: Molecular analysis of biological rhythms
Project/Area Number |
24240058
|
Research Category |
Grant-in-Aid for Scientific Research (A)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Fusional basic brain science
|
Research Institution | Kyoto University |
Principal Investigator |
OKAMURA Hitoshi 京都大学, 薬学研究科(研究院), 教授 (60158813)
|
Co-Investigator(Renkei-kenkyūsha) |
YAMAGUCHI Yoshiaki 京都大学, 大学院薬学研究科, 助教 (30467427)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000)
Fiscal Year 2014: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2013: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2012: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
|
Keywords | 時計遺伝子・視交叉上核・時差 / 生体リズム / 時差 / バソプレッシン / 受容体 / 視交叉上核 / DNAマイクロアレイ / ノックアウトマウス / ペプチド / シグナル伝達 / 生理学 / 脳・神経 |
Outline of Final Research Achievements |
Suprachiasmatic nucleus (SCN) is a center of biological rhythm. SCN emits a powerful circadian rhythm signals to other brain regions and various peripheral organs, and synchronizes systemic clocks in order of the central clock. We started SCN-Gene Project, in which genes expressed in SCN were identified histochemically, and were characterized in rhythms by making their knockout mice. By the SCN-Gene Project, we so far identified animals with longer period length, or with stronger reaction to light pulse in the night. Moreover, we isolated mice without jet lag: they abruptly change their behavioral rhythms when they are exposed to new light-dark cycles. Many of these genes, were not directly related to circadian transcription, but directly linked to intercellular or intracellular signal transductions. These findings suggest that posttranscriptional processes are strongly involved to characterize the nature of the clock.
|
Report
(4 results)
Research Products
(24 results)
-
-
-
-
-
-
[Journal Article] Mice Genetically Deficient in Vasopressin V1a and V1b Receptors Are Resistant to Jet Lag2013
Author(s)
Yamaguchi Y, Suzuki T, Mizoro Y, Kori H, Okada K, Chen Y, Fustin JM, Yamazaki F, Mizuguchi N, Zhang J, Dong X, Tsujimoto G, Okuno Y, Doi M, Okamura H
-
Journal Title
Science
Volume: 342
Issue: 6154
Pages: 85-90
DOI
Related Report
Peer Reviewed
-
[Journal Article] RNA-methylation-dependent RNA processing controls the speed of the circadian clock2013
Author(s)
Fustin JM, Doi M, Yamaguchi Y, Hayashi H, Nishimura S, Yoshida M, Isagawa T, Suimye-Morioka M, Kakeya H, Manabe I, Okamura H
-
Journal Title
Cell
Volume: 155
Issue: 4
Pages: 793-806
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Presentation] 地球と時間と時計遺伝子2014
Author(s)
岡村均
Organizer
第39回日本睡眠学会定期学術集会
Place of Presentation
あわぎんホール(徳島)
Year and Date
2014-07-03 – 2014-07-04
Related Report
Invited
-
-
-
-
-
-
-
-
-
-
-