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Elucidation of the roles of the amygdala-anteriro cingulate loop in regulation of emotional behavior

Research Project

Project/Area Number 24240060
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Fusional social brain science
Research InstitutionKyoto University

Principal Investigator

NAKAMURA Katsuki  京都大学, 霊長類研究所, 教授 (70243110)

Co-Investigator(Kenkyū-buntansha) MIYACHI Shigehiro  京都大学, 霊長類研究所, 准教授 (60392354)
Project Period (FY) 2012-05-31 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥29,770,000 (Direct Cost: ¥22,900,000、Indirect Cost: ¥6,870,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2014: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2012: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords帯状回 / 情動 / 扁桃核 / 側頭極 / サル / 前帯状回 / ニューロン / 側頭葉 / 投射 / 神経トレーサー
Outline of Final Research Achievements

Human imaging studies have suggested that dysfunction of the amygdala-anterior cingulate loop may cause affective disorder and anxiety disorder. However, the existence and function of the loop are still unknown. In the present study, we examined the neural connectivity and responsiveness of the anterior cingulate cortex using monkeys, which have brain structures and function similar to those of humans. We found that, unlike other frontal areas, the anterior cingulated cortex has dense connections with temporal areas related to emotional behavior, such as the temporal pole, perirhinal cortex, and the amygdala. We also found that some anterior cingulate neurons responded to emotional stimuli, such as photos of other monkey faces and snakes. These characteristics of the anterior cingulate may form the basis of its function of emotional regulation.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (5 results)

All 2014 2013 Other

All Presentation (4 results) Remarks (1 results)

  • [Presentation] Projections from the amygdala to subregions of the anterior cingulate cortex in macaque monkeys.2014

    • Author(s)
      Kim Y, Sakata H, Konoike N, Miyachi S, Nakamura K
    • Organizer
      Neuroscience2014
    • Place of Presentation
      Washington DC, (USA)
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Projections from the temporal cortical areas to the sugenual portion of the anterior cingulate cortex in macaque monkeys2014

    • Author(s)
      Sakata H, Kim Y, Konoike N, Miyachi S, Nakamura K
    • Organizer
      Neuroscience2014
    • Place of Presentation
      Washington DC, (USA)
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neurons responsive to faces in the perigenual portion of the anterior cingulate cortex of monkeys.2014

    • Author(s)
      Konoike N, Nakamura K,
    • Organizer
      The 37th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neuronal responses to faces in the anterior cingulate cortex of monkeys.2013

    • Author(s)
      Konoike N., Nakamura K.
    • Organizer
      43th Annual meeting, Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center, San Diego, CA, USA
    • Related Report
      2013 Annual Research Report
  • [Remarks] 京都大学霊長類研究所 神経科学研究部門 高次脳機能分野ホームページ

    • URL

      http://www.pri.kyoto-u.ac.jp/sections/cognitive_neuroscience/index.html

    • Related Report
      2015 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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