|Budget Amount *help
¥47,190,000 (Direct Cost: ¥36,300,000、Indirect Cost: ¥10,890,000)
Fiscal Year 2015: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2014: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2013: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2012: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
|Outline of Final Research Achievements
Multi-scale mechanical behaviors in the lung such as deformation of the organ, force transmission in the tissue and mechanical response to stretch of cell membrane have been elucidated by computational analyses using a mathematical model for inhomogeneous micro structure of the lung parenchyma, a mechanocell model consisting of cell membrane, nuclear and cytoskeletons, and a molecular dynamics model of cell membrane as well as experimental measurements of lung acinus cluster with a synchrotron micro CT. The developed computational modeling and analyses provide an innovative platform to investigate how the cell and tissue biologically respond to the mechanical environment in the lung that largely deforms by breathing.