|Budget Amount *help
¥39,650,000 (Direct Cost: ¥30,500,000、Indirect Cost: ¥9,150,000)
Fiscal Year 2015: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2014: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2013: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2012: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|Outline of Final Research Achievements
In order to create suitable biocompatible materials for various tissue engineering applications, it is important to be able to understand protein adsorption and cell adhesion behaviours on the material surfaces. It is known that the nanoscale distribution of adhesive ligands affects cell adhesion behaviours. However, how nanoscale distribution of adsorbed proteins affect cell adhesion behaviours is still unclear. Therefore, in this study, we investigate the effect of the distribution of adsorbed proteins by the phase reversal of amphiphilic block copolymers composed of protein-adsorptive and non-adsorptive on cell adhesion behaviors. The difference of cell adhesion behaviours between opposite nano phase structures may be caused by the distributions of adsorbed proteins. It was concluded that in addition to the density of adsorbed proteins, the distribution also greatly affects cell adhesion.