Research on functional networks of neurons underlying processing of various memory

• Project/Area Number: 24243069
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental psychology
• Research Institution: Doshisha University (2016); Kyoto University (2012-2015)
• Principal Investigator: Sakurai Yoshio 同志社大学, 脳科学研究科, 教授 (60153962)
• Co-Investigator(Renkei-kenkyūsha): KANEKO TAKESHI 京都大学, 大学院医学研究科, 教授 (90177519) ; AOYAGI TOSHIO 京都大学, 大学院情報学研究科, 教授 (90252486)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥36,010,000 (Direct Cost: ¥27,700,000、Indirect Cost: ¥8,310,000); Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000); Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000); Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000); Fiscal Year 2012: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
• Keywords: 記憶 / 神経回路 / セル・アセンブリ / 海馬 / 扁桃体 / 前頭前野 / ラット / 小脳核 / 時間 / タイミング / ニューロン / 報酬 / LFP / 記憶情報

Outline of Final Research Achievements

This study aimed to experimentally detect activity of functionally connected population of neurons, that is “cell assembly”, underlying various memory processing. We recorded and analyzed multi-neuronal activity of rats performing various memory tasks. The main results are that synchronous activity of neuronal populations between the dorsal hippocampus, amygdala and/or prefrontal cortex appeared when the rats were performing the reward probability discrimination, temporal discrimination, and order discrimination tasks. These findings suggest that activity of macro cell assemblies connecting the different brain region might be the common feature of the mechanisms for processing of various types of memory.

Research Products

• [Journal Article] Inactivation of cerebellar cortical curus II disrupts temporal processing of absolute timing but not relative timing in voluntary movements. (2016)
  • Author(s): Yamaguchi, K. and Sakurai, Y.
  • Journal Title: Frontiers in Systems Neuroscience Volume: 10 (16) Pages: 1-12
  • DOI: 10.3389/fnsys.2016.00016
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] セル・アセンブリと記憶 (2015)
  • Author(s): 櫻井芳雄
  • Journal Title: 生体の科学 Volume: 67 Pages: 32-36
• [Journal Article] ニューロフィードバックの基礎―神経活動のオペラント条件づけ (2015)
  • Author(s): 櫻井芳雄
  • Journal Title: Clinical Neuroscience Volume: 34 Pages: 155-159
• [Journal Article] Theta oscillation and neuronal activity in rat hippocampus are involved in temporal discrimination of time in seconds (2015)
  • Author(s): Nakazono, T., Sano, T., Takahashi, S., Sakurai, Y.
  • Journal Title: Frontiers in Systems Neuroscience Volume: 9 Pages: 1-12
  • DOI: 10.3389/fnsys.2015.00095
  • NAID: 120005947020
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Spike coding mechanisms of cerebellar temporal processing in classical conditioning and voluntary movements (2014)
  • Author(s): Yamaguchi, K. and Sakurai, Y.
  • Journal Title: The Cerebellum Volume: 13 Issue: 5 Pages: 651-658
  • DOI: 10.1007/s12311-014-0580-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Brain-machine interfaces can accelerate clarification of the principal mysteries and real plasticity of the brain. (2014)
  • Author(s): Sakurai, Y.
  • Journal Title: Frontiers in Systems Neuroscience Volume: 8
  • DOI: 10.3389/fnsys.2014.00104
  • NAID: 120005455992
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Recall of Sequences Based on the Position of the First Cue Stimulus in Rats (2014)
  • Author(s): Seiya Ishino, Yoshio Sakurai
  • Journal Title: Cognitive Neurodynamics Volume: (印刷中) Issue: 4 Pages: 345-351
  • DOI: 10.1007/s11571-014-9284-2
  • Peer Reviewed / Open Access
• [Journal Article] Volitional enhancement of firing synchrony and oscillation by neuronal operant conditioning: interaction with neurorehabilitation and brain-machine interface. (2014)
  • Author(s): Sakurai, Y., Song, K., Tachibana, S. and Takahashi, S.
  • Journal Title: Frontiers in Systems Neuroscience Volume: 8 Pages: 1-11
  • DOI: 10.3389/fnsys.2014.00011
  • NAID: 120005385894
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Novel behavioral tasks to explore cerebellar temporal processing in milliseconds in rats. (2014)
  • Author(s): Yamaguchi, K. and Sakurai, Y.
  • Journal Title: Behavioural Brain Research Volume: 263 Pages: 138-143
  • DOI: 10.1016/j.bbr.2014.01.030
  • NAID: 120005385890
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Oscillatory interaction between amygdala and hippocampus coordinates behavioral modulation based on reward expectation. (2013)
  • Author(s): Terada, S., Takahashi, S., and Sakurai, Y.
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 7 (177) Pages: 1-12
  • DOI: 10.3389/fnbeh.2013.00177
  • NAID: 120005349005
  • Peer Reviewed
• [Journal Article] Diverse synchrony of firing reflects diverse cell-assemlby coding in the prefrontal cortex (2013)
  • Author(s): Sakurai, Y., Nakazono, T., Ishino, S., Terada, S., Yamaguchi, K. and Takahashi, S.
  • Journal Title: Journal of Physiology-Paris Volume: 107 Issue: 6 Pages: 459-470
  • DOI: 10.1016/j.jphysparis.2013.05.004
  • Peer Reviewed
• [Journal Article] 順序情報を表現する海馬セル・アセンブリダイナミクス (2013)
  • Author(s): 石野誠也・山口健治・佐野知美・櫻井芳雄
  • Journal Title: 心理学評論 Volume: 56 Pages: 320-327
  • NAID: 130007437019
  • Peer Reviewed
• [Journal Article] 海馬の可塑性と領野間相互作用 (2013)
  • Author(s): 中園智晶・寺田慧・櫻井芳雄
  • Journal Title: 心理学評論 Volume: 56 Pages: 338-354
  • NAID: 130007436932
  • Peer Reviewed
• [Journal Article] Conditioned enhancement of firing rates and synchrony of hippocampal neurons and firing rates of motor cortical neurons in rats. (2013)
  • Author(s): Sakurai, Y. and Takahashi, S.
  • Journal Title: European Journal of Neuroscience Volume: 37 Issue: 4 Pages: 623-639
  • DOI: 10.1111/ejn.12070
  • Peer Reviewed
• [Journal Article] ブレイン－マシン・インタフェースの神経科学 (2012)
  • Author(s): 櫻井芳雄
  • Journal Title: 分子精神医学 Volume: 12 Pages: 23-29
• [Presentation] 再学習中の想起に関わる神経メカニズム (2016)
  • Author(s): 町野友理・高橋晋・櫻井芳雄
  • Organizer: 第９３回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター（札幌市）
  • Year and Date: 2016-03-24
• [Presentation] Effect of reward history under uncertainty (2016)
  • Author(s): 高橋裕美・廣川純也・櫻井芳雄
  • Organizer: 脳と心のメカニズム第16回冬のワークショップ
  • Place of Presentation: ルスツリゾート（北海道蛇田郡留寿都）
  • Year and Date: 2016-01-06
• [Presentation] Transfer of operantly conditioned firings between different neuron groups with BMI in rats (2015)
  • Author(s): Song, K., Takahashi, S. and Sakurai, Y.
  • Organizer: 45th Society for Neuroscience Annual Meeting
  • Place of Presentation: Chicago（米国）
  • Year and Date: 2015-10-21
  • Int'l Joint Research
• [Presentation] ルールスイッチングにおけるラット海馬のシータ・ガンマカップリング (2015)
  • Author(s): 中園智晶・高橋晋・櫻井芳雄
  • Organizer: 第24回海馬と高次脳機能学会
  • Place of Presentation: 岐阜大学サテライトキャンパス（岐阜市）
  • Year and Date: 2015-10-11
• [Presentation] ルール学習中のラット海馬におけるシータ－ガンマ・カップリングはガンマ波のタイプによって異なる (2015)
  • Author(s): 中園智晶・高橋晋・櫻井芳雄
  • Organizer: 第38 回日本神経科学学会大会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-07-30
• [Presentation] Rule switching affects cross-frequency couplings in rat hippocampus. (2015)
  • Author(s): Nakazono, T., Takahashi, S., and Sakurai, Y.
  • Organizer: 5th International Conference on Cognitive Neurodynamics
  • Place of Presentation: Sanya（中国）
  • Year and Date: 2015-06-05
• [Presentation] ブレイン?マシン・インタフェースが示す脳の可塑的変化と制御可能性 (2015)
  • Author(s): 櫻井芳雄
  • Organizer: 第5回鹿児島神経科学研究会
  • Place of Presentation: 鹿児島大学（鹿児島市）
  • Year and Date: 2015-02-21
  • Invited
• [Presentation] Coordinated activity between the hippocampus and the prefrontal cortex related to retrieval of learned sequences in rats. (2014)
  • Author(s): Ishino, S., Takahashi, S. and Sakurai, Y.
  • Organizer: Vision, Memory, Thought: How Cognition Emerges from Neural Network
  • Place of Presentation: 東京大学（東京都）
  • Year and Date: 2014-12-06
• [Presentation] Rule switching affects cross frequency couplings in rat hippocampus. (2014)
  • Author(s): Nakazono, T., Takahashi, S. and Sakurai, Y.
  • Organizer: Vision, Memory, Thought: How Cognition Emerges from Neural Network
  • Place of Presentation: 東京大学（東京都）
  • Year and Date: 2014-12-06
• [Presentation] Hippocampal-prefrontal coordination is involved in recall of learned sequences in rats. (2014)
  • Author(s): Ishino, S., Takahashi, S. and Sakurai, Y.
  • Organizer: 44th Society for Neuroscience Annual Meeting
  • Place of Presentation: Washington, DC (USA)
  • Year and Date: 2014-11-19
• [Presentation] Timed pauses of simple spikes and up-and-down patterns of deep cerebellar nucleus activity code cerebellar temporal processing during voluntary movement tasks. (2014)
  • Author(s): Yamaguchi, K., Takahashi, S. and Sakurai, Y.
  • Organizer: 44th Society for Neuroscience Annual Meeting
  • Place of Presentation: Washington, DC (USA)
  • Year and Date: 2014-11-18
• [Presentation] 衝動性の制御における内側前頭皮質の機能と可塑性を解明するためのブレイン―マシン・インターフェイス． (2014)
  • Author(s): 立花湘太・高橋晋・櫻井芳雄
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-09-13
• [Presentation] 学習した系列の想起に関連する海馬-前頭連合野ネットワークの協調的活動 (2014)
  • Author(s): 石野誠也・高橋晋・櫻井芳雄
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-09-12
• [Presentation] Volitional enhancement of firing synchrony of hippocampal neurons by neuronal operant conditioning.. (2014)
  • Author(s): 櫻井芳雄
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-09-11
• [Presentation] ラット海馬シータオシレーションは時間間隔弁別に関与する. (2014)
  • Author(s): 中園智晶・佐野知美・高橋晋・櫻井芳雄
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-09-11
• [Presentation] ラット皮質におけるオペラント条件づけした発火のニューロン集団間での転移． (2014)
  • Author(s): 宋基燦・高橋晋・櫻井芳雄
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-09-11
• [Presentation] Theta-gamma couplings in rat hippocampus are affected by both rule learning and (2013)
  • Author(s): Nakazono, T., Takahashi, S. and Sakurai, Y.
  • Organizer: International Symposium on Prediction and Decision Making. 京都 (2013年10月13日)．
  • Place of Presentation: 京都大学（京都市）
• [Presentation] ラット海馬のシータ-ガンマカップリングにおけるルールスイッチング課題の影響 (2013)
  • Author(s): 中園智晶・高橋晋・櫻井芳雄
  • Organizer: 包括脳ネットワーク夏のワークショップ
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] Hippocampal-prefrontal interaction is related to recall of learned sequences. (2013)
  • Author(s): 石野誠也・高橋晋・櫻井芳雄
  • Organizer: 包括脳ネットワーク夏のワークショップ
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] 海馬と扁桃体間のガンマオシレーションの同期は報酬予測による行動調節に寄与する． (2013)
  • Author(s): 寺田慧・高橋晋・櫻井芳雄
  • Organizer: 第36回日本神経科学学会大会
  • Place of Presentation: 京都国際会館（京都市）
• [Presentation] ラットのリズムに基づく行動中または時間間隔に基づく行動中に見られる小脳活動． (2013)
  • Author(s): 山口健治・高橋晋・櫻井芳雄
  • Organizer: 第36回日本神経科学学会大会
  • Place of Presentation: 京都国際会館（京都市）
• [Presentation] Dynamic synchrony of firing in the prefrontal cortex in monkeys and rats (2012)
  • Author(s): Sakurai, Y.
  • Organizer: 3rd International Symposium on Prefrontal Cortex
  • Place of Presentation: 京都
• [Presentation] Cerebellar Purkinje-cell spikes interaction during a timing behavior task in the rat (2012)
  • Author(s): Yamaguchi, K.
  • Organizer: 42th Society for Neuroscience Annual Meeting
  • Place of Presentation: New Orleans
• [Presentation] Planning-based behavior and neuronal activity in sequential order information task in rats (2012)
  • Author(s): Ishino, S.
  • Organizer: 42th Society for Neuroscience Annual Meeting
  • Place of Presentation: New Orleans
• [Presentation] Multi-neuronal activities in prefrontal cortex and hippocampus during a rule-switching task in rats (2012)
  • Author(s): Nakazono, T.
  • Organizer: 42th Society for Neuroscience Annual Meeting
  • Place of Presentation: New Orleans
• [Presentation] Interacted neuronal activities between hippocampus and amygdala modulate discrimination behavior expecting for different probability of reward in the rat (2012)
  • Author(s): Terada, S.
  • Organizer: 42th Society for Neuroscience Annual Meeting
  • Place of Presentation: New Orleans
• [Presentation] ニューラルオペラント中の海馬マルチニューロン活動の動態 (2012)
  • Author(s): 櫻井芳雄
  • Organizer: 第21回海馬と高次脳機能学会
  • Place of Presentation: 金沢
• [Presentation] ラットのタイミング行動課題中における時間知覚と小脳プルキンエ細胞のスパイク発火 (2012)
  • Author(s): 山口健治
  • Organizer: 第35回日本神経科学学会大会
  • Place of Presentation: 名古屋
• [Presentation] ラットは系列順序情報を想起したプランニング行動を示した (2012)
  • Author(s): 石野誠也
  • Organizer: 第35回日本神経科学学会大会
  • Place of Presentation: 名古屋
• [Presentation] ラットの異なる報酬予測を担う海馬と扁桃体の相互作用 (2012)
  • Author(s): 寺田慧
  • Organizer: 第35回日本神経科学学会大会
  • Place of Presentation: 名古屋
• [Book] 脳と機械をつないでみたら－BMIから見えてきた (2013)
  • Author(s): 櫻井芳雄
  • Total Pages: 196
  • Publisher: 岩波書店
• [Remarks] 同志社大学脳科学研究科 神経回路情報部門（櫻井ラボ）
  • URL: https://www1.doshisha.ac.jp/~ysakurai/
• [Remarks] 脳神経ダイナミクス（櫻井）ラボ
  • URL: http://www.bun.kyoto-u.ac.jp/~ysakurai/
• [Remarks] 脳神経ダイナミクス（櫻井）ラボ
  • URL: http://www.bun.kyoto-u.ac.jp/~ysakurai/
• [Remarks] 脳神経ダイナミクス（櫻井）ラボ
  • URL: http://www.bun.kyoto-u.ac.jp/~ysakurai/