| Budget Amount *help |
¥46,930,000 (Direct Cost: ¥36,100,000、Indirect Cost: ¥10,830,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2012: ¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
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| Outline of Final Research Achievements |
Maitotoxin (MTX) is a marine toxin produced by the dinoflagellate. The structure-activity relationship of MTX was studied by using synthetic partial structures of MTX. MTX induced Ca2+ influx activity was inhibited by the hydrophobic part corresponding to the C’-F’ and QRS ring, and the IC50 values were estimated to be ca.50 microM, respectively. The inhibitory activity of the QR(S) ring in which the seven-membered S-ring was substituted with six-membered ring, was reduced in ca. six times. However, the NOPQR(S) ring possessing both hydrophobic and hydrophilic moiety was not active. The inhibitory activity of the LMNO ring corresponding to the hydrophilic moiety was less active than that of the hydrophobic part, and there was no significant difference between the enantiomers.
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