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Identification of new macrophages subset expressed nicotinic receptor and those function in intestinal immunity

Research Project

Project/Area Number 24248050
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionThe University of Tokyo

Principal Investigator

Hori Masatoshi  東京大学, 大学院農学生命科学研究科(農学部), 准教授 (70211547)

Co-Investigator(Kenkyū-buntansha) 藤澤 正彦  日本獣医生命科学大学, 獣医学部, 講師 (10508873)
堀口 和秀  福井大学, 医学部, 准教授 (20377451)
道下 正貴  日本獣医生命科学大学, 獣医学部, 講師 (50434147)
Co-Investigator(Renkei-kenkyūsha) MOMOTANI Eiichi  独立行政法人農業, 食品産業技術総合研究機構, 上席研究員 (50355145)
TAJIMA Tsuyoshi  日本獣医生命科学大学, 獣医学部, 助教 (60508878)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥44,460,000 (Direct Cost: ¥34,200,000、Indirect Cost: ¥10,260,000)
Fiscal Year 2015: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2014: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2013: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2012: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Keywordsα7ニコチン様アセチルコリン受容体 / ムスカリン2アセチルコリン受容体 / セロトニン4受容体 / モサプリド / 抗炎症作用 / 術後イレウス / マクロファージ / 好中球 / 消化管 / α7ニコチン様ACh受容体 / セロトニン4受容体 / ムスカリン2ACh受容体 / 炎症 / alpha7nACh受容体 / 5-HT3a受容体 / 5-T4受容体 / α7nAChR / 5-HT3aR / 迷走神経反射 / 消化管運動 / 免疫 / ニコチン受容体 / 迷走神経 / セロトニン / 腸炎
Outline of Final Research Achievements

We found that local anti-inflammatory signaling via 5-HT4R of myenteric motor neuron are existing in postoperative ileus model, then try to identify the detailed mechanisms. Myenteric motor neurons release ACh via 5-HT4R activation. The released ACh can activate smooth muscle cells resulted induction of gastroprokinetic action in healthy condition. In contrast, in inflamed ileum, the released ACh can activate α7nAChR possibly on resident macrophages in small intestine which in turn inhibit macrophages infiltration. Whereas ACh can also stimulate M2 type muscarinic AChR (M2AChR) resulted in inhibition of neutrophil infiltration.
In conclusion, we for the first time found that there are neuronal anti-inflammatory pathway in small intestine through two type of AChRs. One is α7nAChR activation to inbibit macrophages infiltration, the other is M2AChR activation to inhibit neutrophils infiltration.

Report

(5 results)
  • 2016 Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (82 results)

All 2017 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (2 results) Journal Article (20 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 19 results,  Open Access: 7 results,  Acknowledgement Compliant: 8 results) Presentation (58 results) (of which Int'l Joint Research: 7 results,  Invited: 5 results) Remarks (2 results)

  • [Int'l Joint Research] National Taiwan University(Taiwan)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Nevada, School of Medicine(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Oral administration with diosgenin enhances the induction of intestinal T helper 1-like regulatory T cells in a murine model of food allergy.2017

    • Author(s)
      Huang C-H, Wang C-C, Lind Y-J, Hori M, Jan T-R.
    • Journal Title

      International Immunopharmacology

      Volume: 42 Pages: 59-66

    • DOI

      10.1016/j.intimp.2016.11.021

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Micro-coordination of pacemaker potentials in the intestine of the mouse2017

    • Author(s)
      Morishita H, Noda T, Mochizuki N, Kaji N, Hori M, Kajioka S, Nakayama S
    • Journal Title

      Gastroenterology

      Volume: In press

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Epidermal growth factor is a critical regulator of the cytokine IL-33 in intestinal epithelial cells.2016

    • Author(s)
      Islam MS, Horiguchi K, Iino S, Kaji N, Mikawa S, Hori M, Ozaki H.
    • Journal Title

      British Journal of Pharmacology

      Volume: 173 Issue: 16 Pages: 2532-2542

    • DOI

      10.1111/bph.13535

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nitric oxide-induced oxidative stress impairs pacemaker function of murine interstitial cells of Cajal during inflammation2016

    • Author(s)
      Kaji N, Horiguchi K, Iino S, Nakayama S, Ohwada T, Otani Y, Firman, Murata T, Sanders KM, Ozaki H, Hori M
    • Journal Title

      Pharmacological Research

      Volume: 111 Pages: 838-848

    • DOI

      10.1016/j.phrs.2016.07.030

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal macrophages in postoperative ileus.2015

    • Author(s)
      Maehara T; Matsumoto K; Horiguchi K; Kondo M; Iino S; Horie S; Murata T; Tsubone H; Shimada S; Ozaki H; Hori M.
    • Journal Title

      Br J Pharmacol

      Volume: 172(4) Issue: 4 Pages: 1136-1147

    • DOI

      10.1111/bph.13006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Time-dependent changes in inhibitory action of lipopolysaccharide on intestinal motility in rat2015

    • Author(s)
      Mikawa S, Ohta Y, Kaji N, Islam MS, Murata T, Ozaki H, Hori M.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 77 Issue: 11 Pages: 1443-1449

    • DOI

      10.1292/jvms.15-0198

    • NAID

      130005112081

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Anti-emetic drug maropitant induces intestinal motility disorder but not anti-inflammatory action in mice2015

    • Author(s)
      Mikawa S, Yamamoto S, Islam MS, Kaji N, Murata T, Mizuno R, Ozaki H, Hori M.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 77 Issue: 10 Pages: 1195-1199

    • DOI

      10.1292/jvms.15-0182

    • NAID

      130005107606

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Histamine Induces Vascular Hyperpermeability by Increasing Blood Flow and Endothelial Barrier Disruption In Vivo2015

    • Author(s)
      Ashina K, Tsubosaka Y, Nakamura T, Omori K, Kobayashi K, Hori M, Ozaki H, Murata T.
    • Journal Title

      PLoS One

      Volume: 9;10(7) Issue: 7 Pages: e0132367-e0132367

    • DOI

      10.1371/journal.pone.0132367

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Daikenchuto, a traditional Japanese herbal medicine, ameliorates postoperative ileus by anti-inflammatory action through nicotinic acetylcholine receptors.2014

    • Author(s)
      Endo M, Hori M, Ozaki H, Oikawa T, Hanawa T.
    • Journal Title

      Journal of Gastroenterology

      Volume: 49 Issue: 6 Pages: 1026-1039

    • DOI

      10.1007/s00535-013-0854-6

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] TGF-β promote tenascin-C expression in subepithelial myofibroblasts and contribute to intestinal mucosal protection in mice.2014

    • Author(s)
      Islam MS, Kusakabe M, Horiguchi K, Iino S, Nakamura T, Iwanaga K, Hashimoto H, Matsumoto S, Murata T, Hori M, Ozaki H.
    • Journal Title

      British Journal of Pharmacology

      Volume: 171 Issue: 2 Pages: 375-388

    • DOI

      10.1111/bph.12452

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Rikkunshito, a Kampo Medicine, Ameliorates Post-operative Ileus by Anti-inflammatory Action2014

    • Author(s)
      Endo M, Hori M, Ozaki H, Oikawa T, Hanawa T.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 124 Issue: 3 Pages: 374-385

    • DOI

      10.1254/jphs.13182FP

    • NAID

      130003391491

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] IL-17A Induces Hypo-contraction of Intestinal Smooth Muscle via Induction of iNOS in Muscularis Macrophages2014

    • Author(s)
      Mori D, Watanabe N, Kaminuma O, Murata T, Hiroi T, Ozaki H, Hori M.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 125 Issue: 4 Pages: 394-405

    • DOI

      10.1254/jphs.14060FP

    • NAID

      130004677798

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Protease-activated receptor-2 induces proinflammatory cytokine and chemokine gene expression in canine keratinocytes2013

    • Author(s)
      Shingo Maeda
    • Journal Title

      Veterinary Immunology and Immunopathology

      Volume: (印刷中) Issue: 1-2 Pages: 17-25

    • DOI

      10.1016/j.vetimm.2013.01.018

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purinergic P2Y1 receptor signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts2013

    • Author(s)
      Iwanaga K, Murata T, Hori M, Ozaki H
    • Journal Title

      Eur J Pharmacol

      Volume: 702(1-3) Issue: 1-3 Pages: 158-164

    • DOI

      10.1016/j.ejphar.2013.01.025

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] UDP induces intestinal epithelial migration via the P2Y6 receptor2013

    • Author(s)
      Nakamura T, Murata T, Hori M, Ozaki H
    • Journal Title

      Br J Pharmacol

      Volume: 170(4) Issue: 4 Pages: 883-892

    • DOI

      10.1111/bph.12334

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals2012

    • Author(s)
      Tajima T, Murata T, Aritake K, Urade U, Matsuoka T, Narumiya S, Ozaki H, Hori M
    • Journal Title

      Am J Physiol

      Volume: 302(5) Issue: 5 Pages: G524-G534

    • DOI

      10.1152/ajpgi.00264.2011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E2 promotes wound-induced migration of intestinal subepithelial myofibroblasts via EP2, EP3, and EP4 prostanoid receptor activation2012

    • Author(s)
      Iwanaga K, Okada M, Murata T, Hori M, Ozaki H
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 340(3) Issue: 3 Pages: 604-611

    • DOI

      10.1124/jpet.111.189845

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular pathogenesis of bovine Paratuberculosis and human inflammatory bowel diseases2012

    • Author(s)
      Momotani E, Romona NM, Yoshihara K, Momotani Y, Hori M, Ozaki H, Eda S, Ikegami M
    • Journal Title

      Vet Immunol Immunopathol

      Volume: 15;148(1-2) Issue: 1-2 Pages: 55-68

    • DOI

      10.1016/j.vetimm.2012.03.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Mosapride on Prednisolone-Induced Gastric Mucosal Injury and Gastric-Emptying Disorder in Dog2012

    • Author(s)
      Tsukamoto A, Ohno K, Maeda S, Nakashima K, Fukushima K, Fujino Y, Hori M, Tsujimoto H
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 74 Issue: 9 Pages: 1103-1108

    • DOI

      10.1292/jvms.12-0066

    • NAID

      130001879763

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mycobacterium avium subsp. paratuberculosis Lipophilic Antigen Causes Crohn’s Disease-Type Necrotizing Colitis in Mice.2012

    • Author(s)
      Eiichi Momotani, Ozaki H, Hori M, Kuribayashi T, Yamamoto S, Eda S. and Ikegami M.
    • Journal Title

      SpringerPlus

      Volume: 1 Issue: 1 Pages: 47-47

    • DOI

      10.1186/2193-1801-1-47

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Neural anti-inflammatory action mediated through two types of ACh receptors of small intestine in POI model mice. For Mosapride citrate.2017

    • Author(s)
      Hori M
    • Organizer
      ANMA & JSNM Joint Meeting 2017
    • Place of Presentation
      Osaka International Convention Center (OICC) (Osaka・Osaka-city)
    • Year and Date
      2017-03-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural anti-inflammatory action mediated through two types of ACh receptors of small intestine in POI model mice. For Daikenchuto.2017

    • Author(s)
      Hori M
    • Organizer
      ANMA & JSNM Joint Meeting 2017
    • Place of Presentation
      Osaka International Convention Center (OICC) (Osaka・Osaka-city)
    • Year and Date
      2017-03-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acceleration of 5-HT/5-HT3aR signaling for 5-FU-mediated intestinal apoptosis.2017

    • Author(s)
      Mikawa S, Kaji N, Mihara T, Ozaki H, Hori M
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール、長崎アストピア(長崎県・長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Pathogenic role of P2X7 in postoperative ileus2017

    • Author(s)
      Yamazaki T, Mikawa S, Kaji N, Ozaki H, Hori M
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール、長崎アストピア(長崎県・長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] The importance of intestinal macrophages for the anti-inflammatory action mediated by α7nAChR on postoperative ileus.2017

    • Author(s)
      Nakashima J, Mihara T, Kaji N, Ozaki H, Hori M
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール、長崎アストピア(長崎県・長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Th1/Th2/Th17シグナルと腸管運動2016

    • Author(s)
      堀 正敏
    • Organizer
      第12回日本食品免疫学会学術大会
    • Place of Presentation
      東京大学伊藤国際ホール(東京・文京区)
    • Year and Date
      2016-11-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 消化管運動機能に影響を与える可能性がある漢方薬の探索~六君子湯・大建中湯以外の漢方薬に関する文献的な調査研究~2016

    • Author(s)
      及川哲郎、遠藤真理、星野卓之、堀正敏、尾崎博、松本司、小田口浩、花輪壽彦
    • Organizer
      第18回日本神経消化器病学会
    • Place of Presentation
      北海道大学医学部(北海道・札幌市)
    • Year and Date
      2016-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 13C酢酸呼気試験を用いたマウス胃排出遅延モデルの評価2016

    • Author(s)
      遠藤真理、堀正敏、尾崎博、及川哲郎、花輪壽彦
    • Organizer
      第18回日本神経消化器病学会
    • Place of Presentation
      北海道大学医学部(北海道・札幌市)
    • Year and Date
      2016-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] ミオシンホスファターゼ阻害因子CPI-17の機能欠損による大腸輸送能遅延2016

    • Author(s)
      槙 郁風、藤井 渉、角田 茂、梶 典幸、楊 群輝、尾崎 博、堀 正敏
    • Organizer
      第18回日本神経消化器病学会
    • Place of Presentation
      北海道大学医学部(北海道・札幌市)
    • Year and Date
      2016-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 堀 正敏2016

    • Author(s)
      IBSのヒントを探る -消化管における免疫・炎症応答と消化管神経叢―
    • Organizer
      第18回日本神経消化器病学会
    • Place of Presentation
      北海道大学医学部(北海道・札幌市)
    • Year and Date
      2016-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 術後イレウスにおけるホオノキの樹皮成分、ホノキオールによる抗炎症作用2016

    • Author(s)
      三原大輝、三河翔馬、梶典幸、Jan T-R、尾崎博、堀正敏
    • Organizer
      第159回 日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源学部(神奈川県・藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] ミオシンホスファターゼ阻害因子・CPI-17の機能欠損による大腸輸送能遅延2016

    • Author(s)
      槙 郁風、藤井 渉、角田 茂、梶 典幸、楊 群輝、尾崎 博、堀 正敏
    • Organizer
      第159回 日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源学部(神奈川県・藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] 術後イレウスにおける消化管ペースメーカー細胞interstitial cells of Cajalの病態変化2016

    • Author(s)
      梶典幸、中山晋介、堀口和秀、飯野哲、尾崎博、堀正敏
    • Organizer
      第159回 日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源学部(神奈川県・藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] モサプリドクエン酸塩と大建中湯による抗炎症作用機構2016

    • Author(s)
      堀 正敏、遠藤 真理、及川 哲郎、尾崎 博
    • Organizer
      第44回日本潰瘍学会
    • Place of Presentation
      旭川グランドホテル (北海道・旭川市)
    • Year and Date
      2016-09-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] CPI-17ミュータントマウスを用いた正常血圧におけるCPI-17の重要性の証明2016

    • Author(s)
      Qunhui Yang、藤井 渉、梶 典幸、角田 茂、尾崎 博、堀 正敏
    • Organizer
      第58回 日本平滑筋学会
    • Place of Presentation
      東北医科薬科大学 (宮城県・仙台市)
    • Year and Date
      2016-08-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Th1/Th2/Th17誘導型各種消化管炎症応答と消化管運動機能異常2016

    • Author(s)
      堀 正敏、梶 典幸、尾崎 博
    • Organizer
      第58回 日本平滑筋学会
    • Place of Presentation
      東北医科薬科大学 (宮城県・仙台市)
    • Year and Date
      2016-08-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] he function of intestinal pacemaker cells is impaired by nitric oxide derived from resident macrophages and smooth muscle cells during Th1 inflammation.2016

    • Author(s)
      Kaji N, Horiguchi K, Iino S, Nakayama S, Ozaki H and Hori M
    • Organizer
      The 24th International Symposium on Molecular Cell Biology of Macrophages (MMCB2016)
    • Place of Presentation
      Sola city conference center (東京都・千代田区)
    • Year and Date
      2016-06-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The anti-inflammatory effect of honokiol on postoperative ileus.2016

    • Author(s)
      Mihara T, Mikawa S, Kaji N, Jan T-R, Ozaki H and Hori M
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      横浜国際会議場 (横浜市・神奈川県)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Th1 inflammatory signaling impairs pacemaker function of interstitial cells of Cajal through nitric oxide-induced oxidative stress.2016

    • Author(s)
      Kaji N, Nakayama S, Horiguchi K, Iino S, Ozaki H and Hori M
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      横浜国際会議場 (横浜市・神奈川県)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] The anti-inflammatory action of honokiol, a herbal medicinal product,2016

    • Author(s)
      Mihara T,Mikawa S, Kaji N, Jan T-R, Ozaki H and Hori M
    • Organizer
      The Joint Symposium of the 7th Veterinary Research among Universities of Veterinary Medicine in East Asia
    • Place of Presentation
      Hanoi・Vietnam
    • Year and Date
      2016-02-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural anti-inflammatory signaling via activating 5-HT4 receptor in gastrointestine.2016

    • Author(s)
      Hori M
    • Organizer
      The Joint Symposium of the 7th Veterinary Research among Universities of Veterinary Medicine in East Asia
    • Place of Presentation
      Hanoi・Vietnam
    • Year and Date
      2016-02-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 術後イレウスに対するホオノキの樹皮成分、ホノキオールの抗炎症作用2016

    • Author(s)
      Mihara T, Mikawa S, Kaji N, Jan T-R, Ozaki H and Hori M
    • Organizer
      第15回新規素材探索研究会
    • Place of Presentation
      新横浜富士ビューホテル(神奈川県・横浜市)
    • Related Report
      2015 Annual Research Report
  • [Presentation] 大建中湯の構成生薬・乾姜の抗炎症作用を介した術後腸管麻痺改善効果2015

    • Author(s)
      遠藤真理、堀正敏、尾崎博、及川哲郎、小田口浩、花輪嘉彦
    • Organizer
      第17回神経消化器病学会
    • Place of Presentation
      沖縄科学技術大学院大学(沖縄県・国頭郡)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 術後イレウスにおけるホオノキの樹皮成分、ホノキオールによる抗炎症作用2015

    • Author(s)
      三原大輝、三河翔馬、梶典幸、 Jan T-R、尾崎博、堀正敏
    • Organizer
      第17回神経消化器病学会
    • Place of Presentation
      沖縄科学技術大学院大学(沖縄県・国頭郡)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 術後イレウスにおけるInterstitial cells of Cajalの病態変化特性2015

    • Author(s)
      梶 典幸、中山 晋介、飯野 哲、堀口 和秀、尾崎 博、堀 正敏
    • Organizer
      第57回日本平滑筋学会
    • Place of Presentation
      山口大学医学部(山口県・宇部市)
    • Year and Date
      2015-08-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 大建中湯の抗炎症作用~術後腸管麻痺モデルマウスで抗炎作用を発揮する生薬の同定~2015

    • Author(s)
      遠藤真理、堀 正敏、尾崎博、及川哲郎、花輪壽彦
    • Organizer
      第32回和漢医薬学会
    • Place of Presentation
      富山国際会議場(富山県・富山市)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Anti-inflammatory pathway via activation of cholinergic receptors in small intestine2015

    • Author(s)
      Kimura M, Imura Y, Kaji N, Mikawa S, Ozaki H, Hori M
    • Organizer
      Symposium on Multicellular inputs Regulating Muscle Excitability
    • Place of Presentation
      Tahoe City (CA・USA)
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Anti-inflammatory pathway via activation of cholinergic receptors in small intestine2015

    • Author(s)
      Hori M, Kimura H, Imura Y, Kaji N, Mikawa S, Ozaki H.
    • Organizer
      International Conference of Cancer Immunology and Macrophages 2015
    • Place of Presentation
      Ito International Research Center (Tokyo・Bunkyo-ku)
    • Year and Date
      2015-06-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Animal model of postoperative ileus is unique model to determine plastic property of ICC during infl ammation2015

    • Author(s)
      梶 典幸、中山 晋介、堀口 和秀、飯野 哲、村田 幸久、尾崎 博、堀 正敏
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場 (愛知県、名古屋市)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Anti-inflammatory signaling via activation of α7nACh receptors in small intestine2015

    • Author(s)
      堀 正敏、猪村優貴、木村仁美、村田幸久、尾崎 博
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場 (愛知県、名古屋市)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] オンダンセトロンは腹腔マクロファージの5-HT3a受容体を阻害し術後イレウスを改善する2015

    • Author(s)
      堀 正敏、前原 都有子、松本 健次郎、村田 幸久、尾崎 博
    • Organizer
      第11回日本消化管学会総会学術集会
    • Place of Presentation
      京王プラザホテル (東京都、新宿区)
    • Year and Date
      2015-02-13 – 2015-02-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 術後イレウスにおけるセロトニン受容体を介した抗炎症作用(シンポジウム;脳・神経・消化管の機能障害の基礎と臨床)2014

    • Author(s)
      堀 正敏、木村 仁美、土田 泰昭、猪村 優貴、尾崎 博
    • Organizer
      第16回神経消化器病学会合同学術集会
    • Place of Presentation
      学術総合センター (東京都、千代田区)
    • Year and Date
      2014-11-06 – 2014-11-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 大建中湯のα7 ニコチン性アセチルコリン受容体活性化による抗炎症作用を介した術後腸管麻痺改善効果~抗炎症作用を有する生薬の同定~2014

    • Author(s)
      遠藤 真理、堀 正敏、及川哲郎、尾崎博、花輪壽彦
    • Organizer
      第16回神経消化器病学会合同学術集会
    • Place of Presentation
      学術総合センター (東京都、千代田区)
    • Year and Date
      2014-11-06 – 2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 5-HT4 受容体刺激による抗炎症作用はα7nACh 受容体依存性とmACh 受容体依存性の経路を介する2014

    • Author(s)
      木村 仁美、猪村 優貴、梶 典幸、村田 幸久、尾崎 博、堀 正敏
    • Organizer
      第16回神経消化器病学会合同学術集会2014
    • Place of Presentation
      学術総合センター (東京都、千代田区)
    • Year and Date
      2014-11-06 – 2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 消化管機能におけるニューロキニン受容体阻害薬マロピタントの薬理学的解析2014

    • Author(s)
      山本 将平、梶 典幸、村田 幸久、尾崎 博、堀 正敏
    • Organizer
      第16回神経消化器病学会合同学術集会2014
    • Place of Presentation
      学術総合センター (東京都、千代田区)
    • Year and Date
      2014-11-06 – 2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 5-HT4受容体刺激による術後イレウス改善効果はα7nACh受容体依存性と非依存性の経路を介する2014

    • Author(s)
      木村 仁美、猪村 優貴、梶 典幸、村田 幸久、局 博一、尾崎 博、堀 正敏
    • Organizer
      第157日本獣医学会学術集会
    • Place of Presentation
      北海道大学(北海道、札幌市)
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Combined treatment with IFN-γ and LPS impaired pacemaker activity of interstitial cells of Cajal in small intestine2014

    • Author(s)
      N. Kaji, T. Murata, H. Ozaki, M. Hori
    • Organizer
      The 1st Federation of Neurogastroenterology and Motility Meeting
    • Place of Presentation
      Guangzhou Baiyun International Convention Center (Guangzhou, China)
    • Year and Date
      2014-09-05 – 2014-09-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Ameliorative actions of muscularis inflammation by antiemetic drugs, 5-HT3a receptor antagonists, in post-operative ileus2014

    • Author(s)
      M. Hori, T. Maehara, Y. Imura, K. Matsumoto, S Horie, K. Horiguchi, S Iino, M. Kondo, S. Shimada, H. Tsubone, T. Murata, H. Ozaki
    • Organizer
      The 1st Federation of Neurogastroenterology and Motility Meeting
    • Place of Presentation
      Guangzhou Baiyun International Convention Center (Guangzhou, China)
    • Year and Date
      2014-09-05 – 2014-09-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 六君子湯の術後腸管麻痺改善効果の作用機序2014

    • Author(s)
      遠藤真理、堀 正敏 、及川哲郎、尾崎博、花輪壽彦
    • Organizer
      和漢医薬学会学術集会
    • Place of Presentation
      幕張メッセ (千葉県、千葉市)
    • Year and Date
      2014-08-30 – 2014-08-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] IFN-γ/LPSシグナルはInterstitial cell of Cajalのペースメーカー機能を障害する2014

    • Author(s)
      梶 典幸、村田幸久、尾崎 博、堀 正敏
    • Organizer
      第56回日本平滑筋学会総会
    • Place of Presentation
      新横浜プリンスホテル(神奈川県、横浜市)
    • Year and Date
      2014-08-06 – 2014-08-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Inhibition of macrophages but not neutrophils infiltration by 5-HT4R stimulation is mediated through α7nAChR activation post-operative ileus2014

    • Author(s)
      H. Kimura, Y. Imura, N. Kaji, T. Murata, H. Tsubone, H. Ozaki, M. Hori
    • Organizer
      The 22nd International Symposium on Molecular of Macrophages
    • Place of Presentation
      The Kobe Chamber of Commerce and Industry (兵庫県、神戸市)
    • Year and Date
      2014-06-02 – 2014-06-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] α7nACh受容体刺激は術後イレウスにおけるマクロファージ浸潤を特異的に抑制する2014

    • Author(s)
      堀 正敏、猪村優貴、村田幸久、尾崎博
    • Organizer
      第10回日本消化管学会総会学術集会
    • Place of Presentation
      福島ビューホテル、コラッセふくしま、ホテル福島グリーンパレス(福島県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 大建中湯のα7ニコチン性アセチルコリン受容体を介した抗炎症作用による術後腸管麻痺改善効果2014

    • Author(s)
      及川哲郎、遠藤真理、堀正敏、尾崎博、花輪壽彦
    • Organizer
      第10回日本消化管学会総会学術集会
    • Place of Presentation
      福島ビューホテル、コラッセふくしま、ホテル福島グリーンパレス(福島県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Up-regulation of tenascin-C un subepithelial myofibroblasts is critical for intestinal mucosal protection in mice.2014

    • Author(s)
      Md Shafiqul Islam、日下部守昭、堀口和秀、飯野哲、中村達郎、岩永剛一、橋本尚詞、松本敏、村田幸久、堀正敏、尾崎博
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス(鹿児島県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] IL17A upregulates iNOS expression and attenuates intestinal smooth muscle contractility2014

    • Author(s)
      森大祐、渡辺伸昌、神沼修、村田幸久、尾崎博、堀正敏
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター (宮城県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] IL-17AはiNOS発現を介してラット回腸平滑筋の収縮を抑制する2013

    • Author(s)
      森 大祐、村田 幸久、堀 正敏、尾崎 博
    • Organizer
      第55回日本平滑筋学会総会
    • Place of Presentation
      旭川市第節クリスタルホール(北海道)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 病態と平滑筋収縮蛋白系の制御異常2013

    • Author(s)
      堀正敏
    • Organizer
      第55回日本平滑筋学会総会
    • Place of Presentation
      旭川市第節クリスタルホール(北海道)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 六君子湯の抗炎症作用による術後腸管麻痺改善効果2013

    • Author(s)
      遠藤真理、堀 正敏、及川哲郎、尾崎博、花輪壽彦
    • Organizer
      第30回和漢医薬学会学術大会
    • Place of Presentation
      金沢大学角間キャンパス(石川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 術後イレウスにおけるα7nACh受容体を介したマクロファージ選択的抗炎症作用2013

    • Author(s)
      猪村優貴、村田幸久、堀正敏、尾崎博
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学(岐阜県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 5-HT3R阻害剤は腹腔内マクロファージに作用し術後イレウスの炎症を軽減する2013

    • Author(s)
      前原都有子、村田幸久、堀正敏、尾崎博
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学(岐阜県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 六君子湯の抗炎症作用による術後腸管麻痺改善効果2013

    • Author(s)
      遠藤真理、堀 正敏、及川哲郎、尾崎博、花輪壽彦
    • Organizer
      第15回 神経消化器病学会
    • Place of Presentation
      ビックハート出雲(島根県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 術後イレウスにおけるα7nACh受容体を介したマクロファージ選択的抗炎症作用2013

    • Author(s)
      猪村優貴、村田幸久、堀正敏、尾崎博
    • Organizer
      第15回 神経消化器病学会
    • Place of Presentation
      ビックハート出雲(島根県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ameliorative action of 5-HT3 receptor antagonist, ondansetron, for post-operative ileus2013

    • Author(s)
      前原都有子、中村 達朗、村田 幸久、尾崎 博、堀 正敏
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場 (福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mast cell-derived prostaglandin D2 inhibits colitis-associated carcinogenesis through2013

    • Author(s)
      岩永 剛一、村田 幸久、堀 正敏、有竹 浩介、裏出 良博、尾崎 博
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場 (福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mari Endo, Toshihiko Hanawa, Hiroshi Ozaki, Testuro Oikawa, Masatoshi Hori2012

    • Author(s)
      Daikenchuto, a Kampo (Japanese herbal) medicine, ameliorates postoperative ileus by anti-inflammatory action through nACh receptor.
    • Organizer
      2012 DDW
    • Place of Presentation
      アメリカ合衆国(San Diego)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肥満細胞のZnシグナル阻害を介した術後イレウス治療2012

    • Author(s)
      米谷 豊、西田圭吾、伊東 大貴、土田 泰昭、小松 弘嗣、村田 幸久、尾崎 博、
    • Organizer
      第14回日本神経消化器病学会
    • Place of Presentation
      シェラトン都ホテル大阪(大阪府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] IL-17AはiNOS 発現を介してラット回腸平滑筋の収縮を抑制する2012

    • Author(s)
      森 大祐、村田 幸久、堀 正敏、尾崎 博
    • Organizer
      第14回日本神経消化器病学会
    • Place of Presentation
      シェラトン都ホテル大阪(大阪府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 大建中湯の術後腸管麻痺改善効果はα7 ニコチン性アセチルコチン受容体活性化による抗炎症作用を介している2012

    • Author(s)
      遠藤真理、堀 正敏、及川哲郎、尾崎博、花輪壽彦
    • Organizer
      第14回日本神経消化器病学会
    • Place of Presentation
      シェラトン都ホテル大阪(大阪府)
    • Related Report
      2012 Annual Research Report
  • [Remarks] 東京大学大学院農学生命科学研究科 獣医学専攻 獣医薬理学教室

    • URL

      http://www.vm.a.u-tokyo.ac.jp/yakuri/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東京大学大学院 農学生命科学研究科 獣医薬理学教室

    • URL

      http://www.vm.a.u-tokyo.ac.jp/yakuri/

    • Related Report
      2014 Annual Research Report

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Published: 2013-05-15   Modified: 2022-02-16  

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