|Budget Amount *help
¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
Fiscal Year 2015: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2014: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2013: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2012: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
|Outline of Final Research Achievements
Promoting research focused on four issues in the antisense medicine and obtained the following results. An accurate qualitative sequence prediction model program of the antisense molecule was constructed. Syntheses of three types of nucleic acid monomers designed on different concepts were succeeded in. Attention points in the synthesis of oligonucleotides with the artificial nucleic acid monomer were revealed. A cellular uptake, especially on unusual tissue, of oligonucleotides was promoted by conjugating a bioactive synthetic compound.