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Roles of stress-responsive transcription factors in health and disease

Research Project

Project/Area Number 24249015
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionTohoku University

Principal Investigator

YAMAMOTO Masayuki  東北大学, 医学(系)研究科(研究院), 教授 (50166823)

Co-Investigator(Kenkyū-buntansha) KATSUOKA Fumiki  東北大学, 東北メディカルメガバンク機構, 准教授 (30447255)
Co-Investigator(Renkei-kenkyūsha) URUNO Akira  東北大学, 大学院医学系研究科, 講師 (90396474)
SUZUKI Norio  東北大学, 大学院医学系研究科, 講師 (20447254)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000)
Fiscal Year 2014: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2013: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2012: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Keywords酸化ストレス / 転写制御 / 炎症 / 細胞分化 / 病態代謝 / オートファジー / がん / 個体発生
Outline of Final Research Achievements

Transcription factor Nrf2 regulates a broad cytoprotective response to environmental stresses through induction of cellular defense enzymes. Keap1 is an adaptor protein for cullin3-based ubiquitin E3 ligase and negatively regulates Nrf2. This notion has been best demonstrated in animal models, showing that Nrf2-null mice are sensitive to a wide variety of electrophiles and reactive oxygen species (ROS). Keap1 possesses reactive cysteine residues that act as sensors for electrophilic and oxidative stresses. We have verified this model through structure biology, mouse/zebrafish genetics, and human cancer analyses. Elevated expression of NRF2 target genes confers advantages on the growth of cancer cells through the metabolic reprogramming. Thus, the Keap1-Nrf2 system opens a new avenue to the understanding of the signal transduction and regulatory processes underlying the stress response and cancer progression.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (136 results)

All 2015 2014 2013 2012 Other

All Journal Article (82 results) (of which Peer Reviewed: 78 results,  Open Access: 14 results,  Acknowledgement Compliant: 9 results) Presentation (54 results) (of which Invited: 30 results)

  • [Journal Article] Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients.2015

    • Author(s)
      Kanamori M*, Higa T, Sonoda Y, Murakami S, Dodo M, Kitamura H, Taguchi K, Shibata T, Watanabe M, Suzuki H, Shibahara I, Saito R, Yamashita Y, Kumabe T, Yamamoto M, Motohashi H*, and Tominaga T.
    • Journal Title

      Neuro-Oncology

      Volume: 17 Issue: 4 Pages: 555-565

    • DOI

      10.1093/neuonc/nou282

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of a functional antioxidant response element within the eighth intron of the human ABCC3 gene2015

    • Author(s)
      Canet MJ, Merrell MD, Harder BG, Maher JM, Wu T, Lickteig AJ, Jackson JP, Zhang DD, Yamamoto M, and Cherrington NJ.
    • Journal Title

      Drug Metab Dispos.

      Volume: 43 Issue: 1 Pages: 93-99

    • DOI

      10.1124/dmd.114.060103

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Progenitor stage-specific activity of a cis-acting double GATA motif for Gata1 gene expression2015

    • Author(s)
      Moriguchi T, Suzuki M, Yu L, Takai J, Ohneda K, and Yamamoto M. “
    • Journal Title

      Mol Cell Biol

      Volume: 35 Issue: 5 Pages: 805-815

    • DOI

      10.1128/mcb.01011-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism.2015

    • Author(s)
      de Aguiar Vallim TQ, Tarling EJ, Ahn H, Hagey LR, Romanoski CE, Lee RG, Graham MJ, Motohashi H, Yamamoto M, Edwards PA.
    • Journal Title

      Cell Metab

      Volume: 21 Issue: 2 Pages: 298-310

    • DOI

      10.1016/j.cmet.2015.01.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dnmt3a regulates osteoclast differentiation by coupling to an S-adenosyl methionine-producing metabolic pathway.2015

    • Author(s)
      Nishikawa et al.
    • Journal Title

      Nature Medicine

      Volume: 21 Issue: 3 Pages: 281-287

    • DOI

      10.1038/nm.3774

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hypoxia-Sensitive Reporter System for High-Throughput Screening2015

    • Author(s)
      Tsujita, T.; Kawaguchi, S-i.; Dan, T.; Baird, L.; Miyata, T.; Yamamoto, M.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 235 Issue: 2 Pages: 151-159

    • DOI

      10.1620/tjem.235.151

    • NAID

      130004822440

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain2015

    • Author(s)
      Suzuki N, Mukai HY, and Yamamoto M.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 3 Pages: e0119442-e0119442

    • DOI

      10.1371/journal.pone.0119442

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nrf2 enhances cholangiocyte expansion in Pten-deficient livers.2014

    • Author(s)
      Taguchi K, Hirano I, Itoh T, Tanaka M, Miyajima A, Suzuki A, Motohashi H, and Yamamoto M.
    • Journal Title

      Mol. Cell. Biol.

      Volume: 34 Issue: 5 Pages: 900-913

    • DOI

      10.1128/mcb.01384-13

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Kinetic, Thermodynamic and Structural Characterizations of Association between Nrf2-DLGex Degron and Keap1.2014

    • Author(s)
      Fukutomi, T., Takagi, K., Mizushima, T., Ohuchi, N., and Yamamoto, M.
    • Journal Title

      Moll Cell Biol.

      Volume: 34 Issue: 5 Pages: 832-846

    • DOI

      10.1128/mcb.01191-13

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Possible involvementof nuclear factor erythroid 2-related factor 2in the gene expression of Cyp2b10and Cyp2a52014

    • Author(s)
      Ashino T, Ohkubo-Morita H, Yamamoto M, Yoshida T, Numazawa S
    • Journal Title

      Redox Biology

      Volume: 10 Pages: 284-288

    • DOI

      10.1016/j.redox.2013.12.025

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Keap 1-Nrf2 system regulates cell fate determination of hematopoietic stem cells2014

    • Author(s)
      Murakami S., Shimizu R., Romeo P. H., Yamamoto M. Motohashi H.
    • Journal Title

      Genes to Cells

      Volume: 19 Issue: 3 Pages: 239-253

    • DOI

      10.1111/gtc.12126

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NRF2 immunolocalization in human breat cancer patients as a prognostic factor.2014

    • Author(s)
      Onodera Y, Motohashi H, Takagi K, Miki Y, Shibahara Y, Watanabe M, Ishida T, Hirakawa H, Sasano H, Yamamoto M, and Suzuki T.
    • Journal Title

      Endocri Relat Cancer

      Volume: 21 Issue: 2 Pages: 241-252

    • DOI

      10.1530/erc-13-0234

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Notch-Nrf2 axis: Regulation of Nrf2 gene expression and cytoprotection by Notch signaling2014

    • Author(s)
      Wakabayashi N, Skoko JJ, Chartoumpekis DV, Kimura S, Slocum SL, Noda K, Palliyaguru DL, Fujimuro M, Boley PA, Tanaka Y, Shigemura N, Biswal S, Yamamoto M, Kensler TW
    • Journal Title

      Mol Cell Biol

      Volume: 34 Issue: 4 Pages: 653-663

    • DOI

      10.1128/mcb.01408-13

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hematopoietic stem and progenitor cell activation during chronic dermatitis provoked by constitutively active aryl-hydrocarbon receptor driven by keratin 14 promoter2014

    • Author(s)
      Murakami S., Yamamoto M. and Motohashi H
    • Journal Title

      Toxicological Sciences

      Volume: 138 Issue: 1 Pages: 47-58

    • DOI

      10.1093/toxsci/kft273

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice2014

    • Author(s)
      Yagishita Y, Fukutomi T, Sugawara A, Kawamura H, Takahashi T, Pi J, Uruno A, and Yamamoto M.
    • Journal Title

      Diabetes

      Volume: 63 Issue: 2 Pages: 605-618

    • DOI

      10.2337/db13-0909

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Does Nrf2 gene transfer facilitate recovery after contusion spinal cord injury?2014

    • Author(s)
      Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Yla-Herttuala S, Kanninen K, Malm T, Koistinaho J
    • Journal Title

      Antioxid Redox Signal

      Volume: 20 Issue: 8 Pages: 1313-1323

    • DOI

      10.1089/ars.2013.5453

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice.2014

    • Author(s)
      Shirasaki K, Taguchi K, Unno M, Motohashi H, and Yamamoto M
    • Journal Title

      Hepatology

      Volume: 59 Issue: 6 Pages: 2371-2382

    • DOI

      10.1002/hep.27020

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Keap1 inhibition attenuates glomerulosclerosis.2014

    • Author(s)
      Miyazaki Y, Shimizu A, Pastan I, Taguchi K, Naganuma E, Suzuki T, Hosoya T, Yokoo T, Saito A, Miyata T, Yamamoto M, Matsusaka T.
    • Journal Title

      Nephrol Dial Transplant

      Volume: 29 Issue: 4 Pages: 783-791

    • DOI

      10.1093/ndt/gfu002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The circadian clock regulates the NRF2/ARE-mediated antioxidant defence pathway in the mouse lung.2014

    • Author(s)
      Pekovic-Vaughan V, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, Yamamoto M, Chan J, van der Horst GTJ, Fukada Y, and Meng Q-J.
    • Journal Title

      Genes Dev

      Volume: 28 Issue: 6 Pages: 548-560

    • DOI

      10.1101/gad.237081.113

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Remote GATA2 Hematopoietic Enhancer Drives Leukemogenesis in inv(3)(q21 ; q26) by Activating EVI1 Expression2014

    • Author(s)
      Yamazaki H, Suzuki M, Otsuki A, Shimizu R, Bresnick EH, Engel JD, Yamamoto M.
    • Journal Title

      Cancer Cell

      Volume: 25 Issue: 4 Pages: 415-427

    • DOI

      10.1016/j.ccr.2014.02.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2 enhances myocardial clearance of toxic ubiquitinated proteins.2014

    • Author(s)
      Wang W, Li S, Wang H, Li B, Shao L, Lai Y, Horvath G, Wang Q, Yamamoto M, Janicki JS, Wang XL, Tang D, and Cui T.
    • Journal Title

      J Mol Cell Cardiol 72,

      Volume: 72 Pages: 305-315

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis2014

    • Author(s)
      Cazanave SC, Wang X, Zhou H, Rahmani M, Grant S, Durrant DE, Klaassen CD, Yamamoto M, and Sanyal AJ.
    • Journal Title

      Cell Death Differ

      Volume: 21 Pages: 1303-1312

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isocitrate dehydrogenase mutation is frequently observed in giant cell tumor of bone2014

    • Author(s)
      Kato-Kaneko M, Liu X, Oki H, Ogasawara S, Nakamura T, Saidoh N, Tsujimoto Y, Matsuyama Y, Uruno A, Sugawara M, Tsuchiya T, Yamakawa M, Yamamoto M, Takagi M, Kato Y.
    • Journal Title

      Cancer Sci

      Volume: 105 Issue: 6 Pages: 744-748

    • DOI

      10.1111/cas.12413

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Myeloid lineage-specific deletion of antioxidant system enhances tumor metastasis2014

    • Author(s)
      Hiramoto K, Satoh H, Suzuki T, Moriguchi T, Pi J, Shimosegawa T, and Yamamoto M.
    • Journal Title

      Cancer Prev Res (Phila)

      Volume: 7 Pages: 835-844

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice.2014

    • Author(s)
      Hirotsu Y, Higashi C, Fukutomi T, Katsuoka F, Tsujita T, Yagishita Y, Matsuyama Y, Motohashi H, Uruno A, and Yamamoto M.
    • Journal Title

      Mol Cell Biol

      Volume: 19 Issue: 8 Pages: 650-665

    • DOI

      10.1111/gtc.12165

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway2014

    • Author(s)
      Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, and Komatsu M.
    • Journal Title

      J Biol Chem

      Volume: 289 Issue: 36 Pages: 24944-24955

    • DOI

      10.1074/jbc.m114.580357

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes2014

    • Author(s)
      Tsujita T, Peirce V, Baird L, Matsuyama Y, Takaku M, Walsh SV, Griffin JL, Uruno A, Yamamoto M, and Hayes JD.
    • Journal Title

      Mol Cell Biol

      Volume: 34 Issue: 20 Pages: 3800-3816

    • DOI

      10.1128/mcb.00110-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validation of multiple single nucleotide variation calls by additional exome analysis with a semiconductor sequencer to supplement data of whole-genome sequencing of a human population2014

    • Author(s)
      Motoike IN, Matsumoto M, Danjoh I, Katsuoka F, Kojima K, Nariai N, Sato Y, Yamaguchi-Kabata Y, Ito S, Kudo H, Nishijima I, Nishikawa S, Pan X, Saito R, Saito S, Saito T, Shirota M, Tsuda K, Yokozawa J, Igarashi K, Minegishi N, Tanabe O, Fuse N, Nagasaki M, Kinoshita K, Yasuda J, and Yamamoto M.
    • Journal Title

      BMC Genomics

      Volume: 10 Issue: 1 Pages: 637-637

    • DOI

      10.1186/1471-2164-15-673

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PGC-1 Coactivator Activity is Required for Murine Erythropoiesis2014

    • Author(s)
      Cui S, Tanabe O, Lim K-C, Xu HE, Zhou XE, Lin JD, Shi L, Shimizu R, Schmidt L, Campbell A, Yamamoto M, and Engel JD,
    • Journal Title

      Mol Cell Biol

      Volume: 34 Issue: 11 Pages: 1956-1965

    • DOI

      10.1128/mcb.00247-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GATA2 regulates differentiation of bone marrow-derived mesenchymal stem cells2014

    • Author(s)
      Kamata M, Okitsu Y, Fujiwara T, Kanehira M, Nakajima S, Takahashi T, Inoue A, Fukuhara N, Onishi Y, Ishizawa K, Shimizu R, Yamamoto M, and Harigae H.
    • Journal Title

      Haematologica

      Volume: 11 Pages: 1686-1696

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear factor erythroid 2-related factor 2 regulates toll-like receptor 4 innate responses in mouse liver ischemia-reperfusion injury through Akt-forkhead box protein O1 signaling network.2014

    • Author(s)
      Huang J, Yue S, Ke B, Zhu J, Shen XD, Zhai Y, Yamamoto M, Busuttil RW, and Kupiec-Weglinski JW.
    • Journal Title

      Transplantation

      Volume: 98 Issue: 7 Pages: 721-728

    • DOI

      10.1097/tp.0000000000000316

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An efficient quantitation method of next-generation sequencing libraries by using MiSeq sequencer.2014

    • Author(s)
      Katsuoka F, Yokozawa J, Tsuda K, Ito S, Pan X, Nagasaki M, Yasuda J, and Yamamoto M.
    • Journal Title

      Anal Biochem

      Volume: 466 Pages: 27-29

    • DOI

      10.1016/j.ab.2014.08.015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2 induces fibroblast growth factor 21 in diabetic mice2014

    • Author(s)
      Furusawa Y, Uruno A, Yagishita Y, Higashi C, and Yamamoto M.
    • Journal Title

      Genes Cells

      Volume: 19 Issue: 12 Pages: 864-878

    • DOI

      10.1111/gtc.12186

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Keap1-Nrf2系と腎臓病2014

    • Author(s)
      祢津昌広・相馬友和・山本雅之
    • Journal Title

      Annual Review腎臓

      Volume: 2014 Pages: 89-96

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Critical role of Nrf2 in oxidative stress-induced retinal ganglion cell death2013

    • Author(s)
      Himori N, Yamamoto K, Maruyama K, Ryu M, Taguchi K, Yamamoto M, Nakazawa T.
    • Journal Title

      J Neurochem

      Volume: 127 Issue: 5 Pages: 669-680

    • DOI

      10.1111/jnc.12325

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome2013

    • Author(s)
      Xue P, Hou Y, Chen Y, Yang B, Fu J, Zheng H, Yarborough K, Woods CG, Liu D, Yamamoto M, Zhang Q, Andersen ME, Pi J
    • Journal Title

      Diabetes

      Volume: 62 Issue: 3 Pages: 845-854

    • DOI

      10.2337/db12-0584

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of Keap1-Nrf2 system in upper aerodigestive tract carcinogenesis2013

    • Author(s)
      Ohkoshi A, Suzuki T, Ono M, Kobayashi T, Yamamoto M
    • Journal Title

      Cancer Prev Res

      Volume: 6 Pages: 149-159

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling2013

    • Author(s)
      Guiu J, Shimizu R. D'Altri T,Fraser ST, Hatakeyama J, Bresnick EH, Kageyama R, Dzierzak E, Yamamoto M, Espinosa L, Bigas A.
    • Journal Title

      J Exp Med

      Volume: 210(1) Issue: 1 Pages: 71-84

    • DOI

      10.1084/jem.20120993

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The absence of macrophage Nrf2 promotes early atherogenesis2013

    • Author(s)
      Ruotsalainen AK, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Makinen PI, Heinonen SE, Laitinen HM, Heikkila, Vatanen T, Horkko S, Yamamoto M, Yla-Herttuala S, Jauhiainen M, Levonen AL
    • Journal Title

      Cardiovasc Res

      Volume: 98 Issue: 1 Pages: 107-115

    • DOI

      10.1093/cvr/cvt008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia2013

    • Author(s)
      Ashino T, Yamamoto M, Yoshida T, Numazawa S
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 33 Issue: 4 Pages: 760-768

    • DOI

      10.1161/atvbaha.112.300614

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of the hbsll-myb locus causes hereditary persistence of fetal hemoglobin in a mouse model.2013

    • Author(s)
      Suzuki M, Yamazaki H, Mukai HY, Motohashi H, Shi L, Tanabe 0, Engel JD, Yamamoto M.
    • Journal Title

      Molecular and Cellular Biology

      Volume: 33 Issue: 8 Pages: 1687-1695

    • DOI

      10.1128/mcb.01617-12

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome2013

    • Author(s)
      Toki T, Kanezaki R, Kobayashi E, Kaneko H, Suzuki M, Wang R, Terui K, Kanegane H, Maeda M, Endo M, Mizuochi T, Adachi S, Hayashi Y, Yamamoto M, Shimizu R, Ito E.
    • Journal Title

      Blood

      Volume: 121(16) Issue: 16 Pages: 3181-3184

    • DOI

      10.1182/blood-2012-01-405746

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1a and AMPK activation2013

    • Author(s)
      Wang L, Jia Y, Rogers H, Suzuki N, Gassmann M, Wang Q, McPherron AC, Kopp J, Yamamoto M, Noguchi CT
    • Journal Title

      Int J Biochem Cell Biol

      Volume: 45 Issue: 7 Pages: 1155-1164

    • DOI

      10.1016/j.biocel.2013.03.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Keap1-Nrf2 system prevents onset of diabetes mellitus2013

    • Author(s)
      Uruno A, Furusawa Y, Yagishita Y, Fukutomi T, Muramatsu H, Negishi T, Sugawara A, Kensler TW, Yamamoto M
    • Journal Title

      Mol Cell Biol

      Volume: 33 Issue: 15 Pages: 2996-3010

    • DOI

      10.1128/mcb.00225-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mouse model of adult-onset anaemia due to erythropoietin deficiency2013

    • Author(s)
      Yamazaki S, Souma T, Hirano I, Pan X, Minegishi N, Suzuki N, Yamamoto M
    • Journal Title

      Nature Communications

      Volume: 4 Issue: 1 Pages: 1950-1950

    • DOI

      10.1038/ncomms2950

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transforming growth factor-&βinduces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene.2013

    • Author(s)
      Okita Y, Kamoshida A, Suzuki H, Itoh K, Motohashi H, Igarashi K, Ogami T, Koinuma D, Kato M.
    • Journal Title

      J Biol Chem

      Volume: 288 Issue: 28 Pages: 20658-20667

    • DOI

      10.1074/jbc.m113.450478

    • NAID

      120007136878

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasticity of renal erythropoietin-producing cells governs fibrosis2013

    • Author(s)
      Souma T, Yamazaki S, Moriguchi T, Suzuki N, Hirano I, Pan X, Minegishi N, Abe M, Kiyomoto H, Ito S, Yamamoto M
    • Journal Title

      J Am Soc Nephrol

      Volume: 24 Issue: 10 Pages: 1599-1616

    • DOI

      10.1681/asn.2013010030

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Keap1-Nrf2 complex in ischemia-induced hepatocellular damage of mouse liver transplants2013

    • Author(s)
      Ke B, Shen XD, Zhang Y, Ji H, Gao F, Yue S, Kamo N, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW
    • Journal Title

      J Hepatol

      Volume: 59 Issue: 6 Pages: 1200-1207

    • DOI

      10.1016/j.jhep.2013.07.016

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding2013

    • Author(s)
      More VR, Xu J, Shimpi PC, Belgrave C, Luyendyk JP, Yamamoto M, Slitt AL
    • Journal Title

      Free Radic Biol Med

      Volume: 61C Pages: 85-94

    • DOI

      10.1016/j.freeradbiomed.2013.03.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels.2013

    • Author(s)
      Suzuki T, Shibata T, Takaya K, Shiraishi K, Kohno T, Kunitoh H, Tsuta K, Furuta K, Goto K, Hosoda F, Sakamoto H, Motohashi H and Yamamoto M.
    • Journal Title

      Mol Cell Biol

      Volume: 33 Issue: 12 Pages: 2402-2412

    • DOI

      10.1128/mcb.00065-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of the Nrf2-mediated defense system in corneal epithelial wound healing2013

    • Author(s)
      Hayashi R, Himori N, Taguchi K, Ishikawa Y, Uesugi K, Ito M, Duncan T, Tsujikawa M, Nakazawa T, Yamamoto M, Nishida K
    • Journal Title

      Free Radic Biol Med

      Volume: 61C Pages: 333-342

    • DOI

      10.1016/j.freeradbiomed.2013.04.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice2013

    • Author(s)
      Eba S, Hoshikawa Y, Moriguchi T, Mitsuishi Y, Satoh H, Ishida K, Watanabe T, Shimizu T, Shimokawa H, Okada Y, Yamamoto M, Kondo T
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 49 Pages: 324-333

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis2013

    • Author(s)
      Satoh H, Moriguchi T, Takai J, Ebina M, Yamamoto M
    • Journal Title

      Cancer Res

      Volume: 73 Issue: 13 Pages: 4158-4168

    • DOI

      10.1158/0008-5472.can-12-4499

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NF-E2 p45 is important for establishing normal function of platelets.2013

    • Author(s)
      Fujita R, Takayama-Tsujimoto M, Satoh H, Gutiérrez L, Aburatani H, Fujii S, Sarai A, Bresnick EH, Yamamoto M*, and Motohashi H* (* corresponding authors)
    • Journal Title

      Mol Cell Biol

      Volume: 33 Issue: 14 Pages: 2659-2670

    • DOI

      10.1128/mcb.01274-12

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of erythroleukemic GAK14 cells and characterization of GATA1 N-terminal domain2013

    • Author(s)
      Mukai HY, Suzuki M, Nagano M, Ohmori S, Otsuki A, Tsuchida K, Moriguchi T, Ohneda K, Shimizu R, Ohneda O, Yamamoto M,
    • Journal Title

      Genes Cells

      Volume: 18 Issue: 10 Pages: 886-898

    • DOI

      10.1111/gtc.12084

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2 deficiency leads to behavioral, neurochemical and transcriptional changes in mice2013

    • Author(s)
      Muramatsu H, Katsuoka F, Toide K, Shimizu Y, Furusako S, Yamamoto M
    • Journal Title

      Genes Cells

      Volume: 18 Issue: 10 Pages: 899-908

    • DOI

      10.1111/gtc.12083

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation2013

    • Author(s)
      Suzuki M, Kobayashi-Osaki M, Tsutsumi S, Pan X, Ohmori S, Takai J, Moriguchi T, Ohneda O, Ohneda K, Shimizu R, Kanki Y, Kodama T, Aburatani H, Yamamoto M
    • Journal Title

      Genes Cells

      Volume: 18 Issue: 11 Pages: 921-933

    • DOI

      10.1111/gtc.12086

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation2013

    • Author(s)
      Ishikado A, Morino K, Nishio Y, Nakagawa F, Mukose A, Sono Y, Yoshioka N, Kondo K, Sekine O, Yoshizaki T, Ugi S, Uzu T, Kawai H, Makino T, Okamura T, Yamamoto M, Kashiwagi A, Maegawa H
    • Journal Title

      PLoS One

      Volume: 8 Issue: 7 Pages: e69415-e69415

    • DOI

      10.1371/journal.pone.0069415

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration2013

    • Author(s)
      Holmstrom KM, Baird L, Zhang Y, Hargreaves I, Chalasani A, Land JM, Stanyer L, Yamamoto M, Dinkova-Kostova AT, Abramov AY
    • Journal Title

      Biol Open

      Volume: 2 Issue: 8 Pages: 761-770

    • DOI

      10.1242/bio.20134853

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.2013

    • Author(s)
      Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T., Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
    • Journal Title

      Mol Cell

      Volume: 51 Issue: 5 Pages: 618-631

    • DOI

      10.1016/j.molcel.2013.08.003

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Gatal 5' region harbors distinct cis-regulatory modules that direct gene activation in erythroid cells and gene inactivation in HSCs2013

    • Author(s)
      Takai J, Moriguchi T, Suzuki M, Yu L, Ohneda K, and Yamamoto M.
    • Journal Title

      Blood.

      Volume: 122 Issue: 20 Pages: 3450-3460

    • DOI

      10.1182/blood-2013-01-476911

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Verification of the in vivo activity of three distinct cis-acting elements within the Gatal gene promoter-proximal enhancer in mice2013

    • Author(s)
      Shimizu R, Hasegawa A, Ottolenghi S, Ronchi A, Yamamoto M.
    • Journal Title

      Genes to Cells

      Volume: 18(11) Issue: 11 Pages: 1032-1041

    • DOI

      10.1111/gtc.12096

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of a Rho-regulated actin nucleator, mDia2, impairs cytokinesis during mouse fetal erythropoiesis.2013

    • Author(s)
      Watanabe S, De Zan T, Ishizalki T, Yasuda S, Kamijo H, Yamada D, Aoki T, Kiyonari H, Kaneko H, Shimizu R, Yamamoto M, Goshima G, and, Narummiya S
    • Journal Title

      Cell Reports

      Volume: 5(4) Issue: 4 Pages: 926-932

    • DOI

      10.1016/j.celrep.2013.10.021

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis2013

    • Author(s)
      Suzuki N, Hirano I, Pan X, Minegishi N, Yamamoto M
    • Journal Title

      Nature Commun

      Volume: 4 Issue: 1 Pages: 2902-2902

    • DOI

      10.1038/ncomms3902

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 酸化ストレス応答の新展開2013

    • Author(s)
      福富俊明、山本雅之
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 731-736

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Targeted deletion of Nrf2 impairs lung development and oxidant injury in neonatal mice2012

    • Author(s)
      Cho HY, van Houten B, Wang X, Miller-Degraff L, Fostel J, Gladwell W, Perrow L, Panduri V, Kobzik L, Yamamoto M, Bell DA, and Kleeberger SR
    • Journal Title

      Antioxid Redox Signal

      Volume: 17 Issue: 8 Pages: 1066-1082

    • DOI

      10.1089/ars.2011.4288

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcript profiling identifies dynamic gene expression patterns and an important role for Nrf2/Keap1 pathway in the developing mouse esophagus2012

    • Author(s)
      Chen H, Li J, Li H, Hu Y, Tevebaugh W, Yamamoto M, Que J, and Chen X
    • Journal Title

      PLoS One

      Volume: 7 Issue: 5 Pages: e36504-e36504

    • DOI

      10.1371/journal.pone.0036504

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validation of the multiple sensor mechanism of the Keap1-Nrf2 system.2012

    • Author(s)
      Takaya K, Suzuki T, Motohashi H, Onodera K, Satomi S, Kensler TW and Yamamoto M.
    • Journal Title

      Free Rad Biol Med

      Volume: 53 Issue: 4 Pages: 817-827

    • DOI

      10.1016/j.freeradbiomed.2012.06.023

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NF-E2-Related Factor 1 (Nrf1) Serves as a Novel Regulator of Hepatic Lipid Metabolism through Regulation of the Lipin1 and PGC-1β Genes2012

    • Author(s)
      Hirotsu Y, Hataya N, Katsuoka F, Yamamoto M.
    • Journal Title

      Mol Cell Biol.

      Volume: 32 Issue: 14 Pages: 2760-2770

    • DOI

      10.1128/mcb.06706-11

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly Potent Activation of Nrf2 by Topical Tricyclic Bis (Cyano Enone): Implications for Protection against UV Radiation during Thiopurine Therapy2012

    • Author(s)
      Kalra S, Knatko EV, Zhang Y, Honda T, Yamamoto M, and Dinkova-Kostova AT
    • Journal Title

      Cancer Prev Res

      Volume: 5 Issue: 7 Pages: 973-981

    • DOI

      10.1158/1940-6207.capr-12-0041

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuates dopaminergic neurotoxicity in the MPTP- mouse model of Parkinson's disease2012

    • Author(s)
      Kaidery NA, Banerjee R, Yang L, Smirnova NA, Hushpulian DM, Liby KT, Williams CR, Yamamoto M, Kensler TW, Ratan RR, Sporn MB, Beal MF, Gazaryan IG, and Thomas B
    • Journal Title

      Antioxid Redox Signal

      Volume: 18 Issue: 2 Pages: 139-157

    • DOI

      10.1089/ars.2011.4491

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics2012

    • Author(s)
      Abdullah A, Kitteringham NR, Jenkins RE, Goldring C, Higgins L, Yamamoto M, Hayes J, and Park BK
    • Journal Title

      Pharmacol Rep

      Volume: 64 Pages: 680-697

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heme and heme biosynthesis intermediates induce Heme oxygenase-1 and Cytochrome P450 2A5, enzymes with putative sequential roles in heme and bilirubin metabolism: Different requirement for transcription factor Nuclear factor erythroid-derived 2-like 22012

    • Author(s)
      Lämsä V, Levonen AL, Sormunen R, Yamamoto M, Hakkola J
    • Journal Title

      Toxicol Sci

      Volume: 130 Issue: 1 Pages: 132-144

    • DOI

      10.1093/toxsci/kfs237

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.2012

    • Author(s)
      Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, Yamamoto M*, and Motohashi H*.
    • Journal Title

      Cancer Cell

      Volume: 22 Issue: 1 Pages: 66-79

    • DOI

      10.1016/j.ccr.2012.05.016

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Keap1 degradation by autophagy for the maintenance of redox homeostasis2012

    • Author(s)
      Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, and Yamamoto M
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 109 Issue: 34 Pages: 13561-13566

    • DOI

      10.1073/pnas.1121572109

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic evidence of an evolutionarily conserved role for Nrf2 in the protection against oxidative stress2012

    • Author(s)
      Mukaigasa K, Nguyen LT, Li L, Nakajima H, Yamamoto M, and Kobayashi M
    • Journal Title

      Mol Cell Biol

      Volume: 32 Issue: 21 Pages: 4455-4461

    • DOI

      10.1128/mcb.00481-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks2012

    • Author(s)
      Hirotsu Y, Katsuoka F, Funayama R, Nagashima T, Nishida Y, Nakayama K, Engel JD, Yamamoto M.
    • Journal Title

      Nucleic Acids Res.

      Volume: 40 Issue: 20 Pages: 10228-10239

    • DOI

      10.1093/nar/gks827

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation2012

    • Author(s)
      Harada N, Ito K, Hosoya T, Mimura J, Maruyama A, Noguchi N, Yagami KI, Morito N, Takahashi S, Maher JM, Yamamoto M, Itoh K
    • Journal Title

      Free Radic Biol Med

      Volume: 53 Issue: 12 Pages: 2256-2262

    • DOI

      10.1016/j.freeradbiomed.2012.10.001

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation2012

    • Author(s)
      Harada N, Ito K, Hosoya T, Mimura J, Maruyama A, Noguchi N, Yagami KI, Morito N, Takahashi S, Maher JM, Yamamoto M, Itoh K
    • Journal Title

      Free Radic Biol Med

      Volume: 53 Issue: 2 Pages: 2256-2262

    • DOI

      10.1158/1940-6207.capr-12-0401-t

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Keap1-Nrf2 system in cancers: Stress response and anabolic metabolism.2012

    • Author(s)
      Mitsuishi Y, Motohashi H*, and Yamamoto M*
    • Journal Title

      Front. Oncol.

      Volume: 2 Pages: 200-200

    • DOI

      10.3389/fonc.2012.00200

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathophysiological regulation of cellular stress response by Keap1-Nrf2 system2012

    • Author(s)
      Yamamoto M
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 52 Pages: 861-861

    • NAID

      130004505186

    • Related Report
      2012 Annual Research Report
  • [Journal Article] がん細胞におけるKeap1-Nrf2システムの破綻2012

    • Author(s)
      藤田理恵,本橋ほづみ,山本雅之
    • Journal Title

      実験医学

      Volume: 30 Pages: 2814-2821

    • Related Report
      2012 Annual Research Report
  • [Presentation] エリスロポエチン産生細胞とエリスロポエチン遺伝子の発現制御機構2014

    • Author(s)
      山本雅之
    • Organizer
      日本血液学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2014-11-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 酸素と医学2014

    • Author(s)
      山本雅之
    • Organizer
      レドックスシンポジウム
    • Place of Presentation
      名古屋大学(名古屋)
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Keap1-Nrf2制御系と発がん2014

    • Author(s)
      山本雅之
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 9.山本雅之、エリスロポエチン産生細胞と腎疾患、2014

    • Author(s)
      山本雅之
    • Organizer
      第45回新潟腎カンファランス
    • Place of Presentation
      新潟大学(新潟)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Erythropoietin production in neural and neural crest cells during primitive erythropoiesis2014

    • Author(s)
      Masayuki Yamamoto.
    • Organizer
      19th Hemoglobin Switching Conference
    • Place of Presentation
      Oxford, UK
    • Year and Date
      2014-09-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Keap1-Nrf2システムと肝臓・糖尿病2014

    • Author(s)
      山本雅之
    • Organizer
      第1回肝臓と糖尿病・代謝研究会
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 腎臓EPO産生細胞を巡る最近の話題2014

    • Author(s)
      山本雅之
    • Organizer
      第59回日本透析医学会学術集会・総会
    • Place of Presentation
      ポートピアホテル(神戸)
    • Year and Date
      2014-06-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Renal erythropoietin producing cells for anemia and fibrosis2014

    • Author(s)
      Masayuki Yamamoto
    • Organizer
      ISN( International Society of Nephrology ) Nexus Symposium
    • Place of Presentation
      Bergamo, Italy
    • Year and Date
      2014-04-05 – 2014-04-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 肝毒性物質による肝肥大における転写因子Nrf2の役割2013

    • Author(s)
      田口恵子、本橋ほづみ、伊藤暢、田中稔、宮島篤、山本雅之
    • Organizer
      フォーラム2013:衛生薬学・環境トキシコロジー
    • Place of Presentation
      九州大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 転写因子GATA2の尿細管特異的欠損マウスは尿濃縮障害を呈する2013

    • Author(s)
      Yu Lei 、森口 尚、相馬友和、高井淳、山本雅之
    • Organizer
      第23回バゾプレシン研究会
    • Place of Presentation
      慶應義塾大学病院
    • Related Report
      2012 Annual Research Report
  • [Presentation] 転写因子GATA1による胎児型グロビン遺伝子発現制御機構の解析2013

    • Author(s)
      濱中悠賀、鈴木未来子、山㟢博未、清水律子、James Douglas Engel、山本雅之
    • Organizer
      転写研究会 若手ワークショップ@鬼怒川
    • Place of Presentation
      日光市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Reciprocal activation between Nrf2 and a proliferative signaling in liver2013

    • Author(s)
      Keiko Taguchi, Hozumi Motohashi, Masayuki Yamamoto
    • Organizer
      1st International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling
    • Place of Presentation
      University of Tokyo
    • Related Report
      2012 Annual Research Report
  • [Presentation] 白血病逆位モデルマウスを用いたEVI1高発現白血病発症機構の解析2013

    • Author(s)
      鈴木未来子、山㟢博未、加藤幸一郎、清水律子、James Douglas Engel、山本雅之
    • Organizer
      第17回造血器腫瘍研究会
    • Place of Presentation
      宮崎
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functional expansion of Nrf2 under the sustained activation of proliferative signals2013

    • Author(s)
      Hozumi Motohashi, Tsuyoshi Higa, Keiko Taguchi, Yoichiro Mitsuishi, Masayuki Yamamoto
    • Organizer
      Keystone Symposium
    • Place of Presentation
      Santa Fe, NM, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular Mechanisms of the Keap1-Nrf2 Pathway in Stress Response and Cancer Evolution2013

    • Author(s)
      Yamamoto M
    • Organizer
      Special lecture, University of Pittsburgh Cancer Institute
    • Place of Presentation
      Pittsburgh, PA, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 環境応答の分子基盤と病態2013

    • Author(s)
      山本雅之
    • Organizer
      第6回システム疾患生命科学による先端医療技術開発シンポジウム
    • Place of Presentation
      東京大学山上会館
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 動物モデルによる環境応答研究の展開2013

    • Author(s)
      山本雅之
    • Organizer
      第29回日本毒性病理学会学術集会
    • Place of Presentation
      つくば
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 癌悪性化に関わるNrf2-DLG癌変異のKeap1結合阻害の構造的基盤2012

    • Author(s)
      福富俊明,黒河博文,内堀雄介,佐藤雅紀,磯達朗,和泉喜子,里見進,山本雅之
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 転写因子NF-E2 p45による血小板機能調節遺伝子の転写活性化2012

    • Author(s)
      藤田理恵、辻本昌理子、藤井聡、皿井明倫、油谷浩幸、本橋ほづみ、山本雅之
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] がん細胞における酸化ストレス応答機構の役割と代謝リプログラミングへの貢献2012

    • Author(s)
      光石陽一郎、田口恵子、山本雅之、本橋ほづみ
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular Basis Connecting Environmental Stress to Gene Expression Regulation2012

    • Author(s)
      山本雅之
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 肝臓における2つのNrf2活性制御機構と胆管形成2012

    • Author(s)
      田口恵子、本橋ほづみ、山本雅之
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肝特異的Nrf1欠損マウスの作出と肝における脂質代謝経路の解析2012

    • Author(s)
      辻田忠志,Vivian Mullin,Jullian L Griffin,山本雅之,John D Hayes
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Construction of a mammalian artificial chromosome vector for multiple gene delivery2012

    • Author(s)
      Yukari Ogino, Yuji Nakayama, Naruka Matsumori, Nobuyuki Tanaka, Mitsuo Oshimura, Eiji Nanba, Toshiaki Inoue
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Nrf2-小Maf転写因子のゲノムワイド解析による遺伝子発現制御システムの解明2012

    • Author(s)
      弘津陽介, 勝岡史城, 舟山 亮, 長嶋 剛史, 西田 有一郎, 中山 啓子, James Douglas Engel, 山本雅之
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 造血幹細胞・前駆細胞におけるKeap1-Nrf2制御系の役割の解明2012

    • Author(s)
      村上昌平、本橋ほづみ、山本雅之
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 転写因子Nrf2欠損はKras経路の抑制と肺発生関連遺伝子の発現低下を介してウレタン誘導性肺発癌悪性化を阻害する2012

    • Author(s)
      佐藤 大希,森口 尚,海老名 雅仁,貫和 敏博,山本 雅之
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 特定のヘテロ型Keap1変異体は野性型Keap1に対してドミナントネガティブに働く2012

    • Author(s)
      鈴木隆史, Jonathan Maher, 山本雅之
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] The molecular insights into degradation process of ErbB32012

    • Author(s)
      Tomo Funaki, Junko Suga, Tamai Keiichi, Satoh Kennichi, Sugamura Kazuo, Tanaka Nobuyuk
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] Nrf2 ノックアウトマウスはウレタン肺発癌に抵抗性を示し,Nrf2 欠損癌結節はNude マウスへの著しい生着不全を示す2012

    • Author(s)
      佐藤大希,森口尚,海老名雅仁,山本雅之
    • Organizer
      第52回日本呼吸器学会学術総会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Keap1-Nrf2 system for maintenance of redox homeostasis.2012

    • Author(s)
      Taguchi K, Fujikawa N, Motohashi H, and Yamamoto M
    • Organizer
      The 6th International Congress of Asian Society of Toxicology (ASIATOX-VI)
    • Place of Presentation
      Sendai
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vivo validation of the multiple sensing mechanism of the Keap1-Nrf2 system2012

    • Author(s)
      Takafumi Suzuki, Kai Takaya, Hozumi Motohashi, Thomas W Kensler and Masayuki Yamamoto
    • Organizer
      The 33rd NAITO conference
    • Place of Presentation
      Sapporo
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of an inducible liver-specific Nrf1 knockout mouse that has allowed a metabolomic analysis of the development of non-alcoholic steato hepatitis (NASH) in adult animals2012

    • Author(s)
      Tadayuki Tsujita, Vivian Mullin, Jullian L Griffin, Masayuki Yamamoto and John D Hayes
    • Organizer
      The 33rd NAITO conference
    • Place of Presentation
      Sapporo
    • Related Report
      2012 Annual Research Report
  • [Presentation] Crosstalk between Keap1-Nrf2 system and Pten-PI3K-Akt signaling regulates cellular proliferation and differentiation2012

    • Author(s)
      Taguchi K, Motohashi H, and Yamamoto M
    • Organizer
      The 33rd NAITO conference
    • Place of Presentation
      Sapporo
    • Related Report
      2012 Annual Research Report
  • [Presentation] Keap1-Nrf2 System: A Master Regulator of Redox Signaling2012

    • Author(s)
      Yamamoto M
    • Organizer
      The 33rd NAITO conference
    • Place of Presentation
      Sapporo
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Molecular Basis of Keap1-Nrf2 System Function2012

    • Author(s)
      Yamamoto M
    • Organizer
      Oxygen Club California Conference
    • Place of Presentation
      Alba, Italy
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Keap1-Nrf2 system and hematopoiesis2012

    • Author(s)
      Yamamoto M
    • Organizer
      18th Hemoglobin Switching Meeting
    • Place of Presentation
      Asilomar, CA, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 酸化・低酸素ストレスと腎臓2012

    • Author(s)
      山本雅之
    • Organizer
      腎臓内科セミナー
    • Place of Presentation
      東京医科歯科大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 腎臓におけるエリスロポエチン産生REP細胞と線維化2012

    • Author(s)
      山本雅之
    • Organizer
      第21回 腎とエリスロポエチン研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 酸化・低酸素ストレスと腎疾患2012

    • Author(s)
      山本雅之
    • Organizer
      第42回日本腎臓学会西部学術大会
    • Place of Presentation
      沖縄
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Keap1-Nrf2系機能の分子および遺伝学基盤2012

    • Author(s)
      山本雅之
    • Organizer
      日本遺伝学会84回大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Keap1-Nrf2システム機能の分子構造基盤2012

    • Author(s)
      山本雅之
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 環境ストレス応答の分子基盤2012

    • Author(s)
      山本雅之
    • Organizer
      信州大学セミナー
    • Place of Presentation
      信州大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 酸化・低酸素ストレスと腎臓2012

    • Author(s)
      山本雅之
    • Organizer
      第34回腎臓セミナー
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 環境応答破綻と炎症の慢性化2012

    • Author(s)
      山本雅之
    • Organizer
      千里ライフサイエンスセミナー
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 環境応答の分子基盤2012

    • Author(s)
      山本雅之
    • Organizer
      大阪大学GCOEセミナー
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 酸化ストレス応答の分子基盤2012

    • Author(s)
      山本雅之
    • Organizer
      神戸先端医療センターセミナー
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Nrf2酸化ストレス応答系による病態制御2012

    • Author(s)
      山本雅之
    • Organizer
      第53回神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 酸化ストレス応答の分子メカニズムと病態

    • Author(s)
      山本雅之
    • Organizer
      第50回日本臨床分子医学会学術集会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] エリスロポエチン遺伝子の発現制御メカニズム

    • Author(s)
      山本雅之
    • Organizer
      第86回日本内分泌学会学術集会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 赤血球系転写因子の発現制御とエピジェネティクス機構

    • Author(s)
      山本雅之
    • Organizer
      第7回日本エピジェネティクス研究会年会
    • Place of Presentation
      奈良県新公会堂
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Molecular Basis of Environmental Response by Keap1-Nrf2 System

    • Author(s)
      Yamamoto M
    • Organizer
      RCCH symposium
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 抗酸化ストレス転写因子Nrf2欠損マウス由来肺腫瘍はKras経路の抑制と肺腺癌特異的な遺伝子発現低下をきたす

    • Author(s)
      佐藤大希、森口尚、海老名雅仁、山本雅之
    • Organizer
      第53回日本呼吸器学会学術総会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] 門脈枝結紮による代償性肝肥大におけるNrf2の役割

    • Author(s)
      白崎圭一、田口恵子、本橋ほづみ、海野倫明、山本雅之
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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