Roles of stress-responsive transcription factors in health and disease

• Project/Area Number: 24249015
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Tohoku University
• Principal Investigator: YAMAMOTO Masayuki 東北大学, 医学(系)研究科(研究院), 教授 (50166823)
• Co-Investigator(Kenkyū-buntansha): KATSUOKA Fumiki 東北大学, 東北メディカルメガバンク機構, 准教授 (30447255)
• Co-Investigator(Renkei-kenkyūsha): URUNO Akira 東北大学, 大学院医学系研究科, 講師 (90396474) ; SUZUKI Norio 東北大学, 大学院医学系研究科, 講師 (20447254)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000); Fiscal Year 2014: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000); Fiscal Year 2013: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000); Fiscal Year 2012: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
• Keywords: 酸化ストレス / 転写制御 / 炎症 / 細胞分化 / 病態代謝 / オートファジー / がん / 個体発生

Outline of Final Research Achievements

Transcription factor Nrf2 regulates a broad cytoprotective response to environmental stresses through induction of cellular defense enzymes. Keap1 is an adaptor protein for cullin3-based ubiquitin E3 ligase and negatively regulates Nrf2. This notion has been best demonstrated in animal models, showing that Nrf2-null mice are sensitive to a wide variety of electrophiles and reactive oxygen species (ROS). Keap1 possesses reactive cysteine residues that act as sensors for electrophilic and oxidative stresses. We have verified this model through structure biology, mouse/zebrafish genetics, and human cancer analyses. Elevated expression of NRF2 target genes confers advantages on the growth of cancer cells through the metabolic reprogramming. Thus, the Keap1-Nrf2 system opens a new avenue to the understanding of the signal transduction and regulatory processes underlying the stress response and cancer progression.

Research Products

• [Journal Article] Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients. (2015)
  • Author(s): Kanamori M*, Higa T, Sonoda Y, Murakami S, Dodo M, Kitamura H, Taguchi K, Shibata T, Watanabe M, Suzuki H, Shibahara I, Saito R, Yamashita Y, Kumabe T, Yamamoto M, Motohashi H*, and Tominaga T.
  • Journal Title: Neuro-Oncology Volume: 17 Issue: 4 Pages: 555-565
  • DOI: 10.1093/neuonc/nou282
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of a functional antioxidant response element within the eighth intron of the human ABCC3 gene (2015)
  • Author(s): Canet MJ, Merrell MD, Harder BG, Maher JM, Wu T, Lickteig AJ, Jackson JP, Zhang DD, Yamamoto M, and Cherrington NJ.
  • Journal Title: Drug Metab Dispos. Volume: 43 Issue: 1 Pages: 93-99
  • DOI: 10.1124/dmd.114.060103
  • Peer Reviewed
• [Journal Article] Progenitor stage-specific activity of a cis-acting double GATA motif for Gata1 gene expression (2015)
  • Author(s): Moriguchi T, Suzuki M, Yu L, Takai J, Ohneda K, and Yamamoto M. “
  • Journal Title: Mol Cell Biol Volume: 35 Issue: 5 Pages: 805-815
  • DOI: 10.1128/mcb.01011-14
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism. (2015)
  • Author(s): de Aguiar Vallim TQ, Tarling EJ, Ahn H, Hagey LR, Romanoski CE, Lee RG, Graham MJ, Motohashi H, Yamamoto M, Edwards PA.
  • Journal Title: Cell Metab Volume: 21 Issue: 2 Pages: 298-310
  • DOI: 10.1016/j.cmet.2015.01.007
  • Peer Reviewed
• [Journal Article] Dnmt3a regulates osteoclast differentiation by coupling to an S-adenosyl methionine-producing metabolic pathway. (2015)
  • Author(s): Nishikawa et al.
  • Journal Title: Nature Medicine Volume: 21 Issue: 3 Pages: 281-287
  • DOI: 10.1038/nm.3774
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hypoxia-Sensitive Reporter System for High-Throughput Screening (2015)
  • Author(s): Tsujita, T.; Kawaguchi, S-i.; Dan, T.; Baird, L.; Miyata, T.; Yamamoto, M.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 235 Issue: 2 Pages: 151-159
  • DOI: 10.1620/tjem.235.151
  • NAID: 130004822440
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain (2015)
  • Author(s): Suzuki N, Mukai HY, and Yamamoto M.
  • Journal Title: PLoS One Volume: 10 Issue: 3 Pages: e0119442-e0119442
  • DOI: 10.1371/journal.pone.0119442
  • Peer Reviewed / Open Access
• [Journal Article] Nrf2 enhances cholangiocyte expansion in Pten-deficient livers. (2014)
  • Author(s): Taguchi K, Hirano I, Itoh T, Tanaka M, Miyajima A, Suzuki A, Motohashi H, and Yamamoto M.
  • Journal Title: Mol. Cell. Biol. Volume: 34 Issue: 5 Pages: 900-913
  • DOI: 10.1128/mcb.01384-13
  • Peer Reviewed / Open Access
• [Journal Article] Kinetic, Thermodynamic and Structural Characterizations of Association between Nrf2-DLGex Degron and Keap1. (2014)
  • Author(s): Fukutomi, T., Takagi, K., Mizushima, T., Ohuchi, N., and Yamamoto, M.
  • Journal Title: Moll Cell Biol. Volume: 34 Issue: 5 Pages: 832-846
  • DOI: 10.1128/mcb.01191-13
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Possible involvementof nuclear factor erythroid 2-related factor 2in the gene expression of Cyp2b10and Cyp2a5 (2014)
  • Author(s): Ashino T, Ohkubo-Morita H, Yamamoto M, Yoshida T, Numazawa S
  • Journal Title: Redox Biology Volume: 10 Pages: 284-288
  • DOI: 10.1016/j.redox.2013.12.025
  • Peer Reviewed
• [Journal Article] Keap 1-Nrf2 system regulates cell fate determination of hematopoietic stem cells (2014)
  • Author(s): Murakami S., Shimizu R., Romeo P. H., Yamamoto M. Motohashi H.
  • Journal Title: Genes to Cells Volume: 19 Issue: 3 Pages: 239-253
  • DOI: 10.1111/gtc.12126
  • Peer Reviewed
• [Journal Article] NRF2 immunolocalization in human breat cancer patients as a prognostic factor. (2014)
  • Author(s): Onodera Y, Motohashi H, Takagi K, Miki Y, Shibahara Y, Watanabe M, Ishida T, Hirakawa H, Sasano H, Yamamoto M, and Suzuki T.
  • Journal Title: Endocri Relat Cancer Volume: 21 Issue: 2 Pages: 241-252
  • DOI: 10.1530/erc-13-0234
  • Peer Reviewed
• [Journal Article] Notch-Nrf2 axis: Regulation of Nrf2 gene expression and cytoprotection by Notch signaling (2014)
  • Author(s): Wakabayashi N, Skoko JJ, Chartoumpekis DV, Kimura S, Slocum SL, Noda K, Palliyaguru DL, Fujimuro M, Boley PA, Tanaka Y, Shigemura N, Biswal S, Yamamoto M, Kensler TW
  • Journal Title: Mol Cell Biol Volume: 34 Issue: 4 Pages: 653-663
  • DOI: 10.1128/mcb.01408-13
  • Peer Reviewed
• [Journal Article] Hematopoietic stem and progenitor cell activation during chronic dermatitis provoked by constitutively active aryl-hydrocarbon receptor driven by keratin 14 promoter (2014)
  • Author(s): Murakami S., Yamamoto M. and Motohashi H
  • Journal Title: Toxicological Sciences Volume: 138 Issue: 1 Pages: 47-58
  • DOI: 10.1093/toxsci/kft273
  • Peer Reviewed
• [Journal Article] Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice (2014)
  • Author(s): Yagishita Y, Fukutomi T, Sugawara A, Kawamura H, Takahashi T, Pi J, Uruno A, and Yamamoto M.
  • Journal Title: Diabetes Volume: 63 Issue: 2 Pages: 605-618
  • DOI: 10.2337/db13-0909
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Does Nrf2 gene transfer facilitate recovery after contusion spinal cord injury? (2014)
  • Author(s): Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Yla-Herttuala S, Kanninen K, Malm T, Koistinaho J
  • Journal Title: Antioxid Redox Signal Volume: 20 Issue: 8 Pages: 1313-1323
  • DOI: 10.1089/ars.2013.5453
  • Peer Reviewed
• [Journal Article] Nrf2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice. (2014)
  • Author(s): Shirasaki K, Taguchi K, Unno M, Motohashi H, and Yamamoto M
  • Journal Title: Hepatology Volume: 59 Issue: 6 Pages: 2371-2382
  • DOI: 10.1002/hep.27020
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Keap1 inhibition attenuates glomerulosclerosis. (2014)
  • Author(s): Miyazaki Y, Shimizu A, Pastan I, Taguchi K, Naganuma E, Suzuki T, Hosoya T, Yokoo T, Saito A, Miyata T, Yamamoto M, Matsusaka T.
  • Journal Title: Nephrol Dial Transplant Volume: 29 Issue: 4 Pages: 783-791
  • DOI: 10.1093/ndt/gfu002
  • Peer Reviewed / Open Access
• [Journal Article] The circadian clock regulates the NRF2/ARE-mediated antioxidant defence pathway in the mouse lung. (2014)
  • Author(s): Pekovic-Vaughan V, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, Yamamoto M, Chan J, van der Horst GTJ, Fukada Y, and Meng Q-J.
  • Journal Title: Genes Dev Volume: 28 Issue: 6 Pages: 548-560
  • DOI: 10.1101/gad.237081.113
  • Peer Reviewed / Open Access
• [Journal Article] A Remote GATA2 Hematopoietic Enhancer Drives Leukemogenesis in inv(3)(q21 ; q26) by Activating EVI1 Expression (2014)
  • Author(s): Yamazaki H, Suzuki M, Otsuki A, Shimizu R, Bresnick EH, Engel JD, Yamamoto M.
  • Journal Title: Cancer Cell Volume: 25 Issue: 4 Pages: 415-427
  • DOI: 10.1016/j.ccr.2014.02.008
  • Peer Reviewed
• [Journal Article] Nrf2 enhances myocardial clearance of toxic ubiquitinated proteins. (2014)
  • Author(s): Wang W, Li S, Wang H, Li B, Shao L, Lai Y, Horvath G, Wang Q, Yamamoto M, Janicki JS, Wang XL, Tang D, and Cui T.
  • Journal Title: J Mol Cell Cardiol 72, Volume: 72 Pages: 305-315
  • Peer Reviewed
• [Journal Article] Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis (2014)
  • Author(s): Cazanave SC, Wang X, Zhou H, Rahmani M, Grant S, Durrant DE, Klaassen CD, Yamamoto M, and Sanyal AJ.
  • Journal Title: Cell Death Differ Volume: 21 Pages: 1303-1312
  • Peer Reviewed
• [Journal Article] Isocitrate dehydrogenase mutation is frequently observed in giant cell tumor of bone (2014)
  • Author(s): Kato-Kaneko M, Liu X, Oki H, Ogasawara S, Nakamura T, Saidoh N, Tsujimoto Y, Matsuyama Y, Uruno A, Sugawara M, Tsuchiya T, Yamakawa M, Yamamoto M, Takagi M, Kato Y.
  • Journal Title: Cancer Sci Volume: 105 Issue: 6 Pages: 744-748
  • DOI: 10.1111/cas.12413
  • Peer Reviewed / Open Access
• [Journal Article] Myeloid lineage-specific deletion of antioxidant system enhances tumor metastasis (2014)
  • Author(s): Hiramoto K, Satoh H, Suzuki T, Moriguchi T, Pi J, Shimosegawa T, and Yamamoto M.
  • Journal Title: Cancer Prev Res (Phila) Volume: 7 Pages: 835-844
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice. (2014)
  • Author(s): Hirotsu Y, Higashi C, Fukutomi T, Katsuoka F, Tsujita T, Yagishita Y, Matsuyama Y, Motohashi H, Uruno A, and Yamamoto M.
  • Journal Title: Mol Cell Biol Volume: 19 Issue: 8 Pages: 650-665
  • DOI: 10.1111/gtc.12165
  • Peer Reviewed / Open Access
• [Journal Article] Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway (2014)
  • Author(s): Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, and Komatsu M.
  • Journal Title: J Biol Chem Volume: 289 Issue: 36 Pages: 24944-24955
  • DOI: 10.1074/jbc.m114.580357
  • Peer Reviewed / Open Access
• [Journal Article] Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes (2014)
  • Author(s): Tsujita T, Peirce V, Baird L, Matsuyama Y, Takaku M, Walsh SV, Griffin JL, Uruno A, Yamamoto M, and Hayes JD.
  • Journal Title: Mol Cell Biol Volume: 34 Issue: 20 Pages: 3800-3816
  • DOI: 10.1128/mcb.00110-14
  • Peer Reviewed / Open Access
• [Journal Article] Validation of multiple single nucleotide variation calls by additional exome analysis with a semiconductor sequencer to supplement data of whole-genome sequencing of a human population (2014)
  • Author(s): Motoike IN, Matsumoto M, Danjoh I, Katsuoka F, Kojima K, Nariai N, Sato Y, Yamaguchi-Kabata Y, Ito S, Kudo H, Nishijima I, Nishikawa S, Pan X, Saito R, Saito S, Saito T, Shirota M, Tsuda K, Yokozawa J, Igarashi K, Minegishi N, Tanabe O, Fuse N, Nagasaki M, Kinoshita K, Yasuda J, and Yamamoto M.
  • Journal Title: BMC Genomics Volume: 10 Issue: 1 Pages: 637-637
  • DOI: 10.1186/1471-2164-15-673
  • Peer Reviewed / Open Access
• [Journal Article] PGC-1 Coactivator Activity is Required for Murine Erythropoiesis (2014)
  • Author(s): Cui S, Tanabe O, Lim K-C, Xu HE, Zhou XE, Lin JD, Shi L, Shimizu R, Schmidt L, Campbell A, Yamamoto M, and Engel JD,
  • Journal Title: Mol Cell Biol Volume: 34 Issue: 11 Pages: 1956-1965
  • DOI: 10.1128/mcb.00247-14
  • Peer Reviewed
• [Journal Article] GATA2 regulates differentiation of bone marrow-derived mesenchymal stem cells (2014)
  • Author(s): Kamata M, Okitsu Y, Fujiwara T, Kanehira M, Nakajima S, Takahashi T, Inoue A, Fukuhara N, Onishi Y, Ishizawa K, Shimizu R, Yamamoto M, and Harigae H.
  • Journal Title: Haematologica Volume: 11 Pages: 1686-1696
  • Peer Reviewed
• [Journal Article] Nuclear factor erythroid 2-related factor 2 regulates toll-like receptor 4 innate responses in mouse liver ischemia-reperfusion injury through Akt-forkhead box protein O1 signaling network. (2014)
  • Author(s): Huang J, Yue S, Ke B, Zhu J, Shen XD, Zhai Y, Yamamoto M, Busuttil RW, and Kupiec-Weglinski JW.
  • Journal Title: Transplantation Volume: 98 Issue: 7 Pages: 721-728
  • DOI: 10.1097/tp.0000000000000316
  • Peer Reviewed
• [Journal Article] An efficient quantitation method of next-generation sequencing libraries by using MiSeq sequencer. (2014)
  • Author(s): Katsuoka F, Yokozawa J, Tsuda K, Ito S, Pan X, Nagasaki M, Yasuda J, and Yamamoto M.
  • Journal Title: Anal Biochem Volume: 466 Pages: 27-29
  • DOI: 10.1016/j.ab.2014.08.015
  • Peer Reviewed
• [Journal Article] Nrf2 induces fibroblast growth factor 21 in diabetic mice (2014)
  • Author(s): Furusawa Y, Uruno A, Yagishita Y, Higashi C, and Yamamoto M.
  • Journal Title: Genes Cells Volume: 19 Issue: 12 Pages: 864-878
  • DOI: 10.1111/gtc.12186
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Keap1-Nrf2系と腎臓病 (2014)
  • Author(s): 祢津昌広・相馬友和・山本雅之
  • Journal Title: Annual Review腎臓 Volume: 2014 Pages: 89-96
• [Journal Article] Critical role of Nrf2 in oxidative stress-induced retinal ganglion cell death (2013)
  • Author(s): Himori N, Yamamoto K, Maruyama K, Ryu M, Taguchi K, Yamamoto M, Nakazawa T.
  • Journal Title: J Neurochem Volume: 127 Issue: 5 Pages: 669-680
  • DOI: 10.1111/jnc.12325
  • Peer Reviewed
• [Journal Article] Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome (2013)
  • Author(s): Xue P, Hou Y, Chen Y, Yang B, Fu J, Zheng H, Yarborough K, Woods CG, Liu D, Yamamoto M, Zhang Q, Andersen ME, Pi J
  • Journal Title: Diabetes Volume: 62 Issue: 3 Pages: 845-854
  • DOI: 10.2337/db12-0584
  • Peer Reviewed
• [Journal Article] Roles of Keap1-Nrf2 system in upper aerodigestive tract carcinogenesis (2013)
  • Author(s): Ohkoshi A, Suzuki T, Ono M, Kobayashi T, Yamamoto M
  • Journal Title: Cancer Prev Res Volume: 6 Pages: 149-159
  • Peer Reviewed
• [Journal Article] Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling (2013)
  • Author(s): Guiu J, Shimizu R. D'Altri T,Fraser ST, Hatakeyama J, Bresnick EH, Kageyama R, Dzierzak E, Yamamoto M, Espinosa L, Bigas A.
  • Journal Title: J Exp Med Volume: 210(1) Issue: 1 Pages: 71-84
  • DOI: 10.1084/jem.20120993
  • Peer Reviewed
• [Journal Article] The absence of macrophage Nrf2 promotes early atherogenesis (2013)
  • Author(s): Ruotsalainen AK, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Makinen PI, Heinonen SE, Laitinen HM, Heikkila, Vatanen T, Horkko S, Yamamoto M, Yla-Herttuala S, Jauhiainen M, Levonen AL
  • Journal Title: Cardiovasc Res Volume: 98 Issue: 1 Pages: 107-115
  • DOI: 10.1093/cvr/cvt008
  • Peer Reviewed
• [Journal Article] Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia (2013)
  • Author(s): Ashino T, Yamamoto M, Yoshida T, Numazawa S
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 33 Issue: 4 Pages: 760-768
  • DOI: 10.1161/atvbaha.112.300614
  • Peer Reviewed
• [Journal Article] Disruption of the hbsll-myb locus causes hereditary persistence of fetal hemoglobin in a mouse model. (2013)
  • Author(s): Suzuki M, Yamazaki H, Mukai HY, Motohashi H, Shi L, Tanabe 0, Engel JD, Yamamoto M.
  • Journal Title: Molecular and Cellular Biology Volume: 33 Issue: 8 Pages: 1687-1695
  • DOI: 10.1128/mcb.01617-12
  • Peer Reviewed
• [Journal Article] Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome (2013)
  • Author(s): Toki T, Kanezaki R, Kobayashi E, Kaneko H, Suzuki M, Wang R, Terui K, Kanegane H, Maeda M, Endo M, Mizuochi T, Adachi S, Hayashi Y, Yamamoto M, Shimizu R, Ito E.
  • Journal Title: Blood Volume: 121(16) Issue: 16 Pages: 3181-3184
  • DOI: 10.1182/blood-2012-01-405746
  • Peer Reviewed
• [Journal Article] Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1a and AMPK activation (2013)
  • Author(s): Wang L, Jia Y, Rogers H, Suzuki N, Gassmann M, Wang Q, McPherron AC, Kopp J, Yamamoto M, Noguchi CT
  • Journal Title: Int J Biochem Cell Biol Volume: 45 Issue: 7 Pages: 1155-1164
  • DOI: 10.1016/j.biocel.2013.03.007
  • Peer Reviewed
• [Journal Article] The Keap1-Nrf2 system prevents onset of diabetes mellitus (2013)
  • Author(s): Uruno A, Furusawa Y, Yagishita Y, Fukutomi T, Muramatsu H, Negishi T, Sugawara A, Kensler TW, Yamamoto M
  • Journal Title: Mol Cell Biol Volume: 33 Issue: 15 Pages: 2996-3010
  • DOI: 10.1128/mcb.00225-13
  • Peer Reviewed
• [Journal Article] A mouse model of adult-onset anaemia due to erythropoietin deficiency (2013)
  • Author(s): Yamazaki S, Souma T, Hirano I, Pan X, Minegishi N, Suzuki N, Yamamoto M
  • Journal Title: Nature Communications Volume: 4 Issue: 1 Pages: 1950-1950
  • DOI: 10.1038/ncomms2950
  • Peer Reviewed
• [Journal Article] Transforming growth factor-&βinduces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene. (2013)
  • Author(s): Okita Y, Kamoshida A, Suzuki H, Itoh K, Motohashi H, Igarashi K, Ogami T, Koinuma D, Kato M.
  • Journal Title: J Biol Chem Volume: 288 Issue: 28 Pages: 20658-20667
  • DOI: 10.1074/jbc.m113.450478
  • NAID: 120007136878
  • Peer Reviewed
• [Journal Article] Plasticity of renal erythropoietin-producing cells governs fibrosis (2013)
  • Author(s): Souma T, Yamazaki S, Moriguchi T, Suzuki N, Hirano I, Pan X, Minegishi N, Abe M, Kiyomoto H, Ito S, Yamamoto M
  • Journal Title: J Am Soc Nephrol Volume: 24 Issue: 10 Pages: 1599-1616
  • DOI: 10.1681/asn.2013010030
  • Peer Reviewed / Open Access
• [Journal Article] Keap1-Nrf2 complex in ischemia-induced hepatocellular damage of mouse liver transplants (2013)
  • Author(s): Ke B, Shen XD, Zhang Y, Ji H, Gao F, Yue S, Kamo N, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW
  • Journal Title: J Hepatol Volume: 59 Issue: 6 Pages: 1200-1207
  • DOI: 10.1016/j.jhep.2013.07.016
  • Peer Reviewed
• [Journal Article] Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding (2013)
  • Author(s): More VR, Xu J, Shimpi PC, Belgrave C, Luyendyk JP, Yamamoto M, Slitt AL
  • Journal Title: Free Radic Biol Med Volume: 61C Pages: 85-94
  • DOI: 10.1016/j.freeradbiomed.2013.03.007
  • Peer Reviewed
• [Journal Article] Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels. (2013)
  • Author(s): Suzuki T, Shibata T, Takaya K, Shiraishi K, Kohno T, Kunitoh H, Tsuta K, Furuta K, Goto K, Hosoda F, Sakamoto H, Motohashi H and Yamamoto M.
  • Journal Title: Mol Cell Biol Volume: 33 Issue: 12 Pages: 2402-2412
  • DOI: 10.1128/mcb.00065-13
  • Peer Reviewed
• [Journal Article] The role of the Nrf2-mediated defense system in corneal epithelial wound healing (2013)
  • Author(s): Hayashi R, Himori N, Taguchi K, Ishikawa Y, Uesugi K, Ito M, Duncan T, Tsujikawa M, Nakazawa T, Yamamoto M, Nishida K
  • Journal Title: Free Radic Biol Med Volume: 61C Pages: 333-342
  • DOI: 10.1016/j.freeradbiomed.2013.04.008
  • Peer Reviewed
• [Journal Article] The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice (2013)
  • Author(s): Eba S, Hoshikawa Y, Moriguchi T, Mitsuishi Y, Satoh H, Ishida K, Watanabe T, Shimizu T, Shimokawa H, Okada Y, Yamamoto M, Kondo T
  • Journal Title: Am J Respir Cell Mol Biol Volume: 49 Pages: 324-333
  • Peer Reviewed
• [Journal Article] Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis (2013)
  • Author(s): Satoh H, Moriguchi T, Takai J, Ebina M, Yamamoto M
  • Journal Title: Cancer Res Volume: 73 Issue: 13 Pages: 4158-4168
  • DOI: 10.1158/0008-5472.can-12-4499
  • Peer Reviewed
• [Journal Article] NF-E2 p45 is important for establishing normal function of platelets. (2013)
  • Author(s): Fujita R, Takayama-Tsujimoto M, Satoh H, Gutiérrez L, Aburatani H, Fujii S, Sarai A, Bresnick EH, Yamamoto M*, and Motohashi H* (* corresponding authors)
  • Journal Title: Mol Cell Biol Volume: 33 Issue: 14 Pages: 2659-2670
  • DOI: 10.1128/mcb.01274-12
  • Peer Reviewed
• [Journal Article] Establishment of erythroleukemic GAK14 cells and characterization of GATA1 N-terminal domain (2013)
  • Author(s): Mukai HY, Suzuki M, Nagano M, Ohmori S, Otsuki A, Tsuchida K, Moriguchi T, Ohneda K, Shimizu R, Ohneda O, Yamamoto M,
  • Journal Title: Genes Cells Volume: 18 Issue: 10 Pages: 886-898
  • DOI: 10.1111/gtc.12084
  • Peer Reviewed
• [Journal Article] Nrf2 deficiency leads to behavioral, neurochemical and transcriptional changes in mice (2013)
  • Author(s): Muramatsu H, Katsuoka F, Toide K, Shimizu Y, Furusako S, Yamamoto M
  • Journal Title: Genes Cells Volume: 18 Issue: 10 Pages: 899-908
  • DOI: 10.1111/gtc.12083
  • Peer Reviewed
• [Journal Article] GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation (2013)
  • Author(s): Suzuki M, Kobayashi-Osaki M, Tsutsumi S, Pan X, Ohmori S, Takai J, Moriguchi T, Ohneda O, Ohneda K, Shimizu R, Kanki Y, Kodama T, Aburatani H, Yamamoto M
  • Journal Title: Genes Cells Volume: 18 Issue: 11 Pages: 921-933
  • DOI: 10.1111/gtc.12086
  • Peer Reviewed
• [Journal Article] 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation (2013)
  • Author(s): Ishikado A, Morino K, Nishio Y, Nakagawa F, Mukose A, Sono Y, Yoshioka N, Kondo K, Sekine O, Yoshizaki T, Ugi S, Uzu T, Kawai H, Makino T, Okamura T, Yamamoto M, Kashiwagi A, Maegawa H
  • Journal Title: PLoS One Volume: 8 Issue: 7 Pages: e69415-e69415
  • DOI: 10.1371/journal.pone.0069415
  • Peer Reviewed
• [Journal Article] Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration (2013)
  • Author(s): Holmstrom KM, Baird L, Zhang Y, Hargreaves I, Chalasani A, Land JM, Stanyer L, Yamamoto M, Dinkova-Kostova AT, Abramov AY
  • Journal Title: Biol Open Volume: 2 Issue: 8 Pages: 761-770
  • DOI: 10.1242/bio.20134853
  • Peer Reviewed
• [Journal Article] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. (2013)
  • Author(s): Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T., Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
  • Journal Title: Mol Cell Volume: 51 Issue: 5 Pages: 618-631
  • DOI: 10.1016/j.molcel.2013.08.003
  • Peer Reviewed / Open Access
• [Journal Article] The Gatal 5' region harbors distinct cis-regulatory modules that direct gene activation in erythroid cells and gene inactivation in HSCs (2013)
  • Author(s): Takai J, Moriguchi T, Suzuki M, Yu L, Ohneda K, and Yamamoto M.
  • Journal Title: Blood. Volume: 122 Issue: 20 Pages: 3450-3460
  • DOI: 10.1182/blood-2013-01-476911
  • Peer Reviewed
• [Journal Article] Verification of the in vivo activity of three distinct cis-acting elements within the Gatal gene promoter-proximal enhancer in mice (2013)
  • Author(s): Shimizu R, Hasegawa A, Ottolenghi S, Ronchi A, Yamamoto M.
  • Journal Title: Genes to Cells Volume: 18(11) Issue: 11 Pages: 1032-1041
  • DOI: 10.1111/gtc.12096
  • Peer Reviewed
• [Journal Article] Loss of a Rho-regulated actin nucleator, mDia2, impairs cytokinesis during mouse fetal erythropoiesis. (2013)
  • Author(s): Watanabe S, De Zan T, Ishizalki T, Yasuda S, Kamijo H, Yamada D, Aoki T, Kiyonari H, Kaneko H, Shimizu R, Yamamoto M, Goshima G, and, Narummiya S
  • Journal Title: Cell Reports Volume: 5(4) Issue: 4 Pages: 926-932
  • DOI: 10.1016/j.celrep.2013.10.021
  • Peer Reviewed
• [Journal Article] Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis (2013)
  • Author(s): Suzuki N, Hirano I, Pan X, Minegishi N, Yamamoto M
  • Journal Title: Nature Commun Volume: 4 Issue: 1 Pages: 2902-2902
  • DOI: 10.1038/ncomms3902
  • Peer Reviewed
• [Journal Article] 酸化ストレス応答の新展開 (2013)
  • Author(s): 福富俊明、山本雅之
  • Journal Title: 医学のあゆみ Volume: 247 Pages: 731-736
• [Journal Article] Targeted deletion of Nrf2 impairs lung development and oxidant injury in neonatal mice (2012)
  • Author(s): Cho HY, van Houten B, Wang X, Miller-Degraff L, Fostel J, Gladwell W, Perrow L, Panduri V, Kobzik L, Yamamoto M, Bell DA, and Kleeberger SR
  • Journal Title: Antioxid Redox Signal Volume: 17 Issue: 8 Pages: 1066-1082
  • DOI: 10.1089/ars.2011.4288
  • Peer Reviewed
• [Journal Article] Transcript profiling identifies dynamic gene expression patterns and an important role for Nrf2/Keap1 pathway in the developing mouse esophagus (2012)
  • Author(s): Chen H, Li J, Li H, Hu Y, Tevebaugh W, Yamamoto M, Que J, and Chen X
  • Journal Title: PLoS One Volume: 7 Issue: 5 Pages: e36504-e36504
  • DOI: 10.1371/journal.pone.0036504
  • Peer Reviewed
• [Journal Article] Validation of the multiple sensor mechanism of the Keap1-Nrf2 system. (2012)
  • Author(s): Takaya K, Suzuki T, Motohashi H, Onodera K, Satomi S, Kensler TW and Yamamoto M.
  • Journal Title: Free Rad Biol Med Volume: 53 Issue: 4 Pages: 817-827
  • DOI: 10.1016/j.freeradbiomed.2012.06.023
  • Peer Reviewed
• [Journal Article] NF-E2-Related Factor 1 (Nrf1) Serves as a Novel Regulator of Hepatic Lipid Metabolism through Regulation of the Lipin1 and PGC-1β Genes (2012)
  • Author(s): Hirotsu Y, Hataya N, Katsuoka F, Yamamoto M.
  • Journal Title: Mol Cell Biol. Volume: 32 Issue: 14 Pages: 2760-2770
  • DOI: 10.1128/mcb.06706-11
  • Peer Reviewed
• [Journal Article] Highly Potent Activation of Nrf2 by Topical Tricyclic Bis (Cyano Enone): Implications for Protection against UV Radiation during Thiopurine Therapy (2012)
  • Author(s): Kalra S, Knatko EV, Zhang Y, Honda T, Yamamoto M, and Dinkova-Kostova AT
  • Journal Title: Cancer Prev Res Volume: 5 Issue: 7 Pages: 973-981
  • DOI: 10.1158/1940-6207.capr-12-0041
  • Peer Reviewed
• [Journal Article] Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuates dopaminergic neurotoxicity in the MPTP- mouse model of Parkinson's disease (2012)
  • Author(s): Kaidery NA, Banerjee R, Yang L, Smirnova NA, Hushpulian DM, Liby KT, Williams CR, Yamamoto M, Kensler TW, Ratan RR, Sporn MB, Beal MF, Gazaryan IG, and Thomas B
  • Journal Title: Antioxid Redox Signal Volume: 18 Issue: 2 Pages: 139-157
  • DOI: 10.1089/ars.2011.4491
  • Peer Reviewed
• [Journal Article] Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics (2012)
  • Author(s): Abdullah A, Kitteringham NR, Jenkins RE, Goldring C, Higgins L, Yamamoto M, Hayes J, and Park BK
  • Journal Title: Pharmacol Rep Volume: 64 Pages: 680-697
  • Peer Reviewed
• [Journal Article] Heme and heme biosynthesis intermediates induce Heme oxygenase-1 and Cytochrome P450 2A5, enzymes with putative sequential roles in heme and bilirubin metabolism: Different requirement for transcription factor Nuclear factor erythroid-derived 2-like 2 (2012)
  • Author(s): Lämsä V, Levonen AL, Sormunen R, Yamamoto M, Hakkola J
  • Journal Title: Toxicol Sci Volume: 130 Issue: 1 Pages: 132-144
  • DOI: 10.1093/toxsci/kfs237
  • Peer Reviewed
• [Journal Article] Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. (2012)
  • Author(s): Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, Yamamoto M*, and Motohashi H*.
  • Journal Title: Cancer Cell Volume: 22 Issue: 1 Pages: 66-79
  • DOI: 10.1016/j.ccr.2012.05.016
  • Peer Reviewed
• [Journal Article] Keap1 degradation by autophagy for the maintenance of redox homeostasis (2012)
  • Author(s): Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, and Yamamoto M
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 109 Issue: 34 Pages: 13561-13566
  • DOI: 10.1073/pnas.1121572109
  • Peer Reviewed
• [Journal Article] Genetic evidence of an evolutionarily conserved role for Nrf2 in the protection against oxidative stress (2012)
  • Author(s): Mukaigasa K, Nguyen LT, Li L, Nakajima H, Yamamoto M, and Kobayashi M
  • Journal Title: Mol Cell Biol Volume: 32 Issue: 21 Pages: 4455-4461
  • DOI: 10.1128/mcb.00481-12
  • Peer Reviewed
• [Journal Article] Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks (2012)
  • Author(s): Hirotsu Y, Katsuoka F, Funayama R, Nagashima T, Nishida Y, Nakayama K, Engel JD, Yamamoto M.
  • Journal Title: Nucleic Acids Res. Volume: 40 Issue: 20 Pages: 10228-10239
  • DOI: 10.1093/nar/gks827
  • Peer Reviewed
• [Journal Article] Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation (2012)
  • Author(s): Harada N, Ito K, Hosoya T, Mimura J, Maruyama A, Noguchi N, Yagami KI, Morito N, Takahashi S, Maher JM, Yamamoto M, Itoh K
  • Journal Title: Free Radic Biol Med Volume: 53 Issue: 12 Pages: 2256-2262
  • DOI: 10.1016/j.freeradbiomed.2012.10.001
  • Peer Reviewed
• [Journal Article] Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation (2012)
  • Author(s): Harada N, Ito K, Hosoya T, Mimura J, Maruyama A, Noguchi N, Yagami KI, Morito N, Takahashi S, Maher JM, Yamamoto M, Itoh K
  • Journal Title: Free Radic Biol Med Volume: 53 Issue: 2 Pages: 2256-2262
  • DOI: 10.1158/1940-6207.capr-12-0401-t
  • Peer Reviewed
• [Journal Article] The Keap1-Nrf2 system in cancers: Stress response and anabolic metabolism. (2012)
  • Author(s): Mitsuishi Y, Motohashi H*, and Yamamoto M*
  • Journal Title: Front. Oncol. Volume: 2 Pages: 200-200
  • DOI: 10.3389/fonc.2012.00200
  • Peer Reviewed
• [Journal Article] Pathophysiological regulation of cellular stress response by Keap1-Nrf2 system (2012)
  • Author(s): Yamamoto M
  • Journal Title: Rinsho Shinkeigaku Volume: 52 Pages: 861-861
  • NAID: 130004505186
• [Journal Article] がん細胞におけるKeap1-Nrf2システムの破綻 (2012)
  • Author(s): 藤田理恵，本橋ほづみ，山本雅之
  • Journal Title: 実験医学 Volume: 30 Pages: 2814-2821
• [Presentation] エリスロポエチン産生細胞とエリスロポエチン遺伝子の発現制御機構 (2014)
  • Author(s): 山本雅之
  • Organizer: 日本血液学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪）
  • Year and Date: 2014-11-02
  • Invited
• [Presentation] 酸素と医学 (2014)
  • Author(s): 山本雅之
  • Organizer: レドックスシンポジウム
  • Place of Presentation: 名古屋大学（名古屋）
  • Year and Date: 2014-10-11
  • Invited
• [Presentation] Keap1-Nrf2制御系と発がん (2014)
  • Author(s): 山本雅之
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜）
  • Year and Date: 2014-09-27
  • Invited
• [Presentation] 9.山本雅之、エリスロポエチン産生細胞と腎疾患、 (2014)
  • Author(s): 山本雅之
  • Organizer: 第45回新潟腎カンファランス
  • Place of Presentation: 新潟大学（新潟）
  • Year and Date: 2014-09-25
  • Invited
• [Presentation] Erythropoietin production in neural and neural crest cells during primitive erythropoiesis (2014)
  • Author(s): Masayuki Yamamoto.
  • Organizer: 19th Hemoglobin Switching Conference
  • Place of Presentation: Oxford, UK
  • Year and Date: 2014-09-05
  • Invited
• [Presentation] Keap1-Nrf2システムと肝臓・糖尿病 (2014)
  • Author(s): 山本雅之
  • Organizer: 第1回肝臓と糖尿病・代謝研究会
  • Place of Presentation: 東京大学（東京）
  • Year and Date: 2014-07-04
  • Invited
• [Presentation] 腎臓EPO産生細胞を巡る最近の話題 (2014)
  • Author(s): 山本雅之
  • Organizer: 第59回日本透析医学会学術集会・総会
  • Place of Presentation: ポートピアホテル（神戸）
  • Year and Date: 2014-06-13
  • Invited
• [Presentation] Renal erythropoietin producing cells for anemia and fibrosis (2014)
  • Author(s): Masayuki Yamamoto
  • Organizer: ISN( International Society of Nephrology ) Nexus Symposium
  • Place of Presentation: Bergamo, Italy
  • Year and Date: 2014-04-05 – 2014-04-06
  • Invited
• [Presentation] 肝毒性物質による肝肥大における転写因子Nrf2の役割 (2013)
  • Author(s): 田口恵子、本橋ほづみ、伊藤暢、田中稔、宮島篤、山本雅之
  • Organizer: フォーラム2013：衛生薬学・環境トキシコロジー
  • Place of Presentation: 九州大学
• [Presentation] 転写因子GATA2の尿細管特異的欠損マウスは尿濃縮障害を呈する (2013)
  • Author(s): Yu Lei 、森口 尚、相馬友和、高井淳、山本雅之
  • Organizer: 第23回バゾプレシン研究会
  • Place of Presentation: 慶應義塾大学病院
• [Presentation] 転写因子GATA1による胎児型グロビン遺伝子発現制御機構の解析 (2013)
  • Author(s): 濱中悠賀、鈴木未来子、山㟢博未、清水律子、James Douglas Engel、山本雅之
  • Organizer: 転写研究会 若手ワークショップ＠鬼怒川
  • Place of Presentation: 日光市
• [Presentation] Reciprocal activation between Nrf2 and a proliferative signaling in liver (2013)
  • Author(s): Keiko Taguchi, Hozumi Motohashi, Masayuki Yamamoto
  • Organizer: 1st International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling
  • Place of Presentation: University of Tokyo
• [Presentation] 白血病逆位モデルマウスを用いたEVI1高発現白血病発症機構の解析 (2013)
  • Author(s): 鈴木未来子、山㟢博未、加藤幸一郎、清水律子、James Douglas Engel、山本雅之
  • Organizer: 第17回造血器腫瘍研究会
  • Place of Presentation: 宮崎
• [Presentation] Functional expansion of Nrf2 under the sustained activation of proliferative signals (2013)
  • Author(s): Hozumi Motohashi, Tsuyoshi Higa, Keiko Taguchi, Yoichiro Mitsuishi, Masayuki Yamamoto
  • Organizer: Keystone Symposium
  • Place of Presentation: Santa Fe, NM, USA
• [Presentation] Molecular Mechanisms of the Keap1-Nrf2 Pathway in Stress Response and Cancer Evolution (2013)
  • Author(s): Yamamoto M
  • Organizer: Special lecture, University of Pittsburgh Cancer Institute
  • Place of Presentation: Pittsburgh, PA, USA
  • Invited
• [Presentation] 環境応答の分子基盤と病態 (2013)
  • Author(s): 山本雅之
  • Organizer: 第6回システム疾患生命科学による先端医療技術開発シンポジウム
  • Place of Presentation: 東京大学山上会館
  • Invited
• [Presentation] 動物モデルによる環境応答研究の展開 (2013)
  • Author(s): 山本雅之
  • Organizer: 第２９回日本毒性病理学会学術集会
  • Place of Presentation: つくば
  • Invited
• [Presentation] 癌悪性化に関わるNrf2-DLG癌変異のKeap1結合阻害の構造的基盤 (2012)
  • Author(s): 福富俊明,黒河博文,内堀雄介,佐藤雅紀,磯達朗,和泉喜子,里見進,山本雅之
  • Organizer: 第８５回日本生化学会大会
  • Place of Presentation: 福岡国際会議場
• [Presentation] 転写因子NF-E2 p45による血小板機能調節遺伝子の転写活性化 (2012)
  • Author(s): 藤田理恵、辻本昌理子、藤井聡、皿井明倫、油谷浩幸、本橋ほづみ、山本雅之
  • Organizer: 第８５回日本生化学会大会
  • Place of Presentation: 福岡国際会議場
• [Presentation] がん細胞における酸化ストレス応答機構の役割と代謝リプログラミングへの貢献 (2012)
  • Author(s): 光石陽一郎、田口恵子、山本雅之、本橋ほづみ
  • Organizer: 第８５回日本生化学会大会
  • Place of Presentation: 福岡国際会議場
• [Presentation] Molecular Basis Connecting Environmental Stress to Gene Expression Regulation (2012)
  • Author(s): 山本雅之
  • Organizer: 第８５回日本生化学会大会
  • Place of Presentation: 福岡国際会議場
  • Invited
• [Presentation] 肝臓における２つのNrf2活性制御機構と胆管形成 (2012)
  • Author(s): 田口恵子、本橋ほづみ、山本雅之
  • Organizer: 第８５回日本生化学会大会
  • Place of Presentation: 福岡国際会議場
• [Presentation] 肝特異的Nrf1欠損マウスの作出と肝における脂質代謝経路の解析 (2012)
  • Author(s): 辻田忠志,Vivian Mullin,Jullian L Griffin,山本雅之,John D Hayes
  • Organizer: 第８５回日本生化学会大会
  • Place of Presentation: 福岡国際会議場
• [Presentation] Construction of a mammalian artificial chromosome vector for multiple gene delivery (2012)
  • Author(s): Yukari Ogino, Yuji Nakayama, Naruka Matsumori, Nobuyuki Tanaka, Mitsuo Oshimura, Eiji Nanba, Toshiaki Inoue
  • Organizer: 第３５回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場
• [Presentation] Nrf2-小Maf転写因子のゲノムワイド解析による遺伝子発現制御システムの解明 (2012)
  • Author(s): 弘津陽介, 勝岡史城, 舟山 亮, 長嶋 剛史, 西田 有一郎, 中山 啓子, James Douglas Engel, 山本雅之
  • Organizer: 第３５回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場
• [Presentation] 造血幹細胞・前駆細胞におけるKeap1-Nrf2制御系の役割の解明 (2012)
  • Author(s): 村上昌平、本橋ほづみ、山本雅之
  • Organizer: 第３５回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場
• [Presentation] 転写因子Nrf2欠損はKras経路の抑制と肺発生関連遺伝子の発現低下を介してウレタン誘導性肺発癌悪性化を阻害する (2012)
  • Author(s): 佐藤 大希,森口 尚,海老名 雅仁,貫和 敏博,山本 雅之
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 特定のヘテロ型Keap1変異体は野性型Keap1に対してドミナントネガティブに働く (2012)
  • Author(s): 鈴木隆史, Jonathan Maher, 山本雅之
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] The molecular insights into degradation process of ErbB3 (2012)
  • Author(s): Tomo Funaki, Junko Suga, Tamai Keiichi, Satoh Kennichi, Sugamura Kazuo, Tanaka Nobuyuk
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] Nrf2 ノックアウトマウスはウレタン肺発癌に抵抗性を示し,Nrf2 欠損癌結節はNude マウスへの著しい生着不全を示す (2012)
  • Author(s): 佐藤大希,森口尚,海老名雅仁,山本雅之
  • Organizer: 第５２回日本呼吸器学会学術総会
  • Place of Presentation: 神戸
• [Presentation] Keap1-Nrf2 system for maintenance of redox homeostasis. (2012)
  • Author(s): Taguchi K, Fujikawa N, Motohashi H, and Yamamoto M
  • Organizer: The 6th International Congress of Asian Society of Toxicology (ASIATOX-VI)
  • Place of Presentation: Sendai
• [Presentation] In vivo validation of the multiple sensing mechanism of the Keap1-Nrf2 system (2012)
  • Author(s): Takafumi Suzuki, Kai Takaya, Hozumi Motohashi, Thomas W Kensler and Masayuki Yamamoto
  • Organizer: The 33rd NAITO conference
  • Place of Presentation: Sapporo
• [Presentation] Development of an inducible liver-specific Nrf1 knockout mouse that has allowed a metabolomic analysis of the development of non-alcoholic steato hepatitis (NASH) in adult animals (2012)
  • Author(s): Tadayuki Tsujita, Vivian Mullin, Jullian L Griffin, Masayuki Yamamoto and John D Hayes
  • Organizer: The 33rd NAITO conference
  • Place of Presentation: Sapporo
• [Presentation] Crosstalk between Keap1-Nrf2 system and Pten-PI3K-Akt signaling regulates cellular proliferation and differentiation (2012)
  • Author(s): Taguchi K, Motohashi H, and Yamamoto M
  • Organizer: The 33rd NAITO conference
  • Place of Presentation: Sapporo
• [Presentation] Keap1-Nrf2 System: A Master Regulator of Redox Signaling (2012)
  • Author(s): Yamamoto M
  • Organizer: The 33rd NAITO conference
  • Place of Presentation: Sapporo
  • Invited
• [Presentation] Molecular Basis of Keap1-Nrf2 System Function (2012)
  • Author(s): Yamamoto M
  • Organizer: Oxygen Club California Conference
  • Place of Presentation: Alba, Italy
  • Invited
• [Presentation] Keap1-Nrf2 system and hematopoiesis (2012)
  • Author(s): Yamamoto M
  • Organizer: 18th Hemoglobin Switching Meeting
  • Place of Presentation: Asilomar, CA, USA
  • Invited
• [Presentation] 酸化・低酸素ストレスと腎臓 (2012)
  • Author(s): 山本雅之
  • Organizer: 腎臓内科セミナー
  • Place of Presentation: 東京医科歯科大学
  • Invited
• [Presentation] 腎臓におけるエリスロポエチン産生REP細胞と線維化 (2012)
  • Author(s): 山本雅之
  • Organizer: 第21回 腎とエリスロポエチン研究会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 酸化・低酸素ストレスと腎疾患 (2012)
  • Author(s): 山本雅之
  • Organizer: 第42回日本腎臓学会西部学術大会
  • Place of Presentation: 沖縄
  • Invited
• [Presentation] Keap1-Nrf2系機能の分子および遺伝学基盤 (2012)
  • Author(s): 山本雅之
  • Organizer: 日本遺伝学会84回大会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] Keap1-Nrf2システム機能の分子構造基盤 (2012)
  • Author(s): 山本雅之
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Invited
• [Presentation] 環境ストレス応答の分子基盤 (2012)
  • Author(s): 山本雅之
  • Organizer: 信州大学セミナー
  • Place of Presentation: 信州大学
  • Invited
• [Presentation] 酸化・低酸素ストレスと腎臓 (2012)
  • Author(s): 山本雅之
  • Organizer: 第34回腎臓セミナー
  • Place of Presentation: 東京
  • Invited
• [Presentation] 環境応答破綻と炎症の慢性化 (2012)
  • Author(s): 山本雅之
  • Organizer: 千里ライフサイエンスセミナー
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 環境応答の分子基盤 (2012)
  • Author(s): 山本雅之
  • Organizer: 大阪大学GCOEセミナー
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 酸化ストレス応答の分子基盤 (2012)
  • Author(s): 山本雅之
  • Organizer: 神戸先端医療センターセミナー
  • Place of Presentation: 神戸
  • Invited
• [Presentation] Nrf2酸化ストレス応答系による病態制御 (2012)
  • Author(s): 山本雅之
  • Organizer: 第53回神経学会学術大会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 酸化ストレス応答の分子メカニズムと病態
  • Author(s): 山本雅之
  • Organizer: 第50回日本臨床分子医学会学術集会
  • Place of Presentation: 東京国際フォーラム
  • Invited
• [Presentation] エリスロポエチン遺伝子の発現制御メカニズム
  • Author(s): 山本雅之
  • Organizer: 第86回日本内分泌学会学術集会
  • Place of Presentation: 仙台国際センター
  • Invited
• [Presentation] 赤血球系転写因子の発現制御とエピジェネティクス機構
  • Author(s): 山本雅之
  • Organizer: 第7回日本エピジェネティクス研究会年会
  • Place of Presentation: 奈良県新公会堂
  • Invited
• [Presentation] Molecular Basis of Environmental Response by Keap1-Nrf2 System
  • Author(s): Yamamoto M
  • Organizer: RCCH symposium
  • Place of Presentation: Seoul, Korea
  • Invited
• [Presentation] 抗酸化ストレス転写因子Nrf2欠損マウス由来肺腫瘍はKras経路の抑制と肺腺癌特異的な遺伝子発現低下をきたす
  • Author(s): 佐藤大希、森口尚、海老名雅仁、山本雅之
  • Organizer: 第53回日本呼吸器学会学術総会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 門脈枝結紮による代償性肝肥大におけるNrf2の役割
  • Author(s): 白崎圭一、田口恵子、本橋ほづみ、海野倫明、山本雅之
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: パシフィコ横浜