Transmission dynamics and evolution of influenza viruses in Asia

• Project/Area Number: 24249041
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Tohoku University
• Principal Investigator: Oshitani Hitoshi 東北大学, 医学(系)研究科(研究院), 教授 (80419994)
• Co-Investigator(Kenkyū-buntansha): KAMIGAKI Taro 東北大学, 大学院医学系研究科, 助教 (80451524) ; SUZUKI Akira 東北大学, 大学院医学系研究科, 助教 (20443989)
• Research Collaborator: SAITO Mariko (OBATA Mariko) ; OKAMOTO Michiko ; SAITO Mayuko ; TAMAKI Raita ; FURUSE Yuki ; NUKIWA Nao ; KHANDAKER Irona ; OKADA Takashi ; ODAGIRI Takashi ; IMAGAWA Toshifumi ; MIMURA Satoshi ; IMAMURA Tadatsugu ; KOSAI Hisato ; CHAW Liling ; Liu XIAOFANG ; Ngako Kadji Francois Marie ; OHNO Ayumu ; OTOMARU Hisano ; TOHMA Kentaro ; OHTANI Kanako ; Huo Xiang ; TAKAHASHI Yoshihiro ; FUJI Naoko ; MATSUZAKI Yoko ; HONGO Seiji ; Lupisan S. フィリピン国RITM ; Tandoc A. フィリピン国RITM ; Tallo V. フィリピン国RITM ; Tan A. フィリピン国RITM ; Alday P. フィリピン国RITM ; Nymadawa P. モンゴル国 National Influenza Center及びNational Centre of Communicable Diseases ; Nyamaa G. モンゴル国 National Influenza Center及びNational Centre of Communicable Diseases ; Burmaa A. モンゴル国 National Influenza Center及びNational Centre of Communicable Diseases ; Darmaa B. モンゴル国 National Influenza Center及びNational Centre of Communicable Diseases ; Bayasgalan N. モンゴル国 National Influenza Center及びNational Centre of Communicable Diseases ; Od I. モンゴル国 National Influenza Center及びNational Centre of Communicable Diseases ; Tsatsral S. モンゴル国 National Influenza Center及びNational Centre of Communicable Diseases ; Maitsetseg C. モンゴル国 National Influenza Center及びNational Centre of Communicable Diseases
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥39,390,000 (Direct Cost: ¥30,300,000、Indirect Cost: ¥9,090,000); Fiscal Year 2015: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000); Fiscal Year 2014: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000); Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000); Fiscal Year 2012: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
• Keywords: インフルエンザ / トランスミッション / モンゴル / フィリピン / ウイルス / 疫学 / アジア / 伝播

Outline of Final Research Achievements

Transmission dynamics of influenza viruses were analyzed in study sites in three countries; Philippines, Mongolia and Japan. Enhanced surveillance was conducted in Baguio City and Tacloban City in the Philippines and Odate City of Akita Prefecture in Japan, while the community-based cohort study was conducted in Baganuur District of Ulaanbataar City in Mongolia. Through these studies some important epidemiological findings have been obtained, which include; 1) significant role of children in transmission of influenza viruses, 2) transmission and maintenance mechanism of influenza viruses in the Philippines, which is located in tropical area, 3) low incidence of influenza in infants and pregnant women in Mongolia.

Research Products

• [Int'l Joint Research] National Center of Communicable Diseases/Monglian Academy of Medical Sciences(モンゴル)
• [Int'l Joint Research] Research Institute for Tropical Medicine(フィリピン)
• [Journal Article] Burden of Influenza and Respiratory Syncytial Virus Infection in Pregnant Women and Infants Under 6 Months in Mongolia: A Prospective Cohort Study. (2016)
  • Author(s): Chaw L, Kamigaki T, Burmaa A, Urtnasan C, Od I, Nyamaa G, Nymadawa P, Oshitani H.
  • Journal Title: PLoS One Volume: 11
  • DOI: 10.1371/journal.pone.0148421
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Local persistence and global dissemination play a significant role in the circulation of influenza B viruses in Leyte Island, Philippines. (2016)
  • Author(s): Furuse Y, Odagiri T, Tamaki R, Kamigaki T, Otomaru H, Opinion J, Santo A, Dolina-Lacaba D, Daya E, Okamoto M, Saito-Obata M, Inobaya M, Tan A, Tallo V, Lupisan S, Suzuki A, Oshitani H.
  • Journal Title: Virology Volume: 492 Pages: 21-24
  • DOI: 10.1016/j.virol.2016.02.001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influenza and other respiratory viruses detected by influenza-like illness surveillance in Leyte Island, the Philippines, 2010-2013 (2015)
  • Author(s): Otomaru H, Kamigaki T, Tamaki R, Opinion J, Santo A, Daya E, Okamoto M, Saito M, Tallo V, Lupisan S, Suzuki A, Oshitani H
  • Journal Title: PLoS One Volume: -
  • DOI: 10.1371/journal.pone.0123755
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Role of Preschool and Primary School Children in Epidemics of Influenza A in a Local Community in Japan during Two Consecutive Seasons with A(H3N2) as a Predominant Subtype. (2015)
  • Author(s): Mimura S, Kamigaki T, Takahashi Y, Umenai T, Kudou M, Oshitani H.
  • Journal Title: PLoS One Volume: 10
  • DOI: 10.1371/journal.pone.0125642
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Analysis of influenza transmission in the households of primary and junior high school students during the 2012-13 influenza season in Odate, Japan. (2015)
  • Author(s): Kamigaki T, Mimura S, Takahashi Y, Oshitani H.
  • Journal Title: BMC Infect Dis Volume: 23 Pages: 282-282
  • DOI: 10.1186/s12879-015-1007-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Molecular Epidemiology of the Human Rhinovirus Infection in Mongolia during 2008–2013 (2015)
  • Author(s): Tsatsral S, Xiang Z, Fuji N, Maitsetseg C, Khulan J, Oshitani H, Wang J, Nymadawa P.
  • Journal Title: Japanese Journal of Infectious Diseases Volume: 68 Issue: 4 Pages: 280-287
  • DOI: 10.7883/yoken.jjid.2014.090 10.7883/yoken.JJID.2014.090
  • NAID: 130005088807
  • ISSN: 1344-6304, 1884-2836
  • Peer Reviewed / Open Access
• [Journal Article] Isolation and characterization of influenza C viruses in the Philippines and Japan (2015)
  • Author(s): Odagiri T, Matsuzaki Y, Okamoto M, Suzuki A, Saito M, Tamaki R, Lupisan SP, Sombrero LT, Hongo S, Oshitani H.
  • Journal Title: J Clin Microbiol Volume: 53 Pages: 847-858
  • DOI: 10.1128/jcm.02628-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Role of preschool and primary school children in epidemics of influenza A in a local community in Japan during two consecutive seasons with A(H3N2) as a predominant subtype (2015)
  • Author(s): Mimura S, Kamigaki T, Takahashi Y, Umenai T, Kudou M, Oshitani H
  • Journal Title: PLoS One Volume: 印刷中
  • Acknowledgement Compliant
• [Journal Article] School closures during the 2009 influenza pandemic: national and local experiences. (2014)
  • Author(s): Cauchemez S, Van Kerkhove MD, Archer BN, Cetron M, Cowling BJ, Grove P, Hunt D, Kojouharova M, Kon P, Ungchusak K, Oshitani H, Pugliese A, Rizzo C, Saour G, Sunagawa T, Uzicanin A, Wachtel C, Weisfuse I, Yu H, Nicoll A.
  • Journal Title: BMC Infect Dis. Volume: 14 Pages: 1-1
  • DOI: 10.1186/1471-2334-14-207
  • Peer Reviewed / Open Access
• [Journal Article] Epidemiology and impact of influenza in Mongolia, 2007-2012 (2014)
  • Author(s): Burmaa A, Kamigaki T, Darmaa B, Nymadawa P, Oshitani H.
  • Journal Title: Influenza Other Respir Viruses. Volume: 8 Pages: 530-537
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of medical consultation interval between the symptom onset and consultation observed in multiple medical facilities in Odate city, Japan, 2011-2013 seasons (2014)
  • Author(s): Huo X, Kamigaki T, Mimura S, Takahashi Y, Oshitani H
  • Journal Title: J Infect Chemother. Volume: In press Pages: 370-374
  • DOI: 10.1016/j.jiac.2014.02.005
  • Peer Reviewed / Open Access
• [Journal Article] Estimating influenza outpatients' and inpatients' incidences from 2009 to 2011 in a tropical urban setting in the Philippines (2014)
  • Author(s): Tallo VL, Kamigaki T, Tan AG, Pamaran RR, Alday PP, Mercado ES, Javier JB, Oshitani H, Olveda RM
  • Journal Title: Influenza Other Respir Viruses Volume: 8 Pages: 159-168
  • DOI: 10.1111/irv.12223
  • Peer Reviewed
• [Journal Article] Epidemiological characterization of influenza A(H1N1)pdm09 cases from 2009 to 2010 in Baguio City, the Philippines (2013)
  • Author(s): Pamaran RR, Kamigaki T, Hewe TT, Flores KM, Mercado ES, Alday PP, Tan AG, Oshitani H, Olveda RM, Tallo VL
  • Journal Title: PLoS One Volume: 8
  • DOI: 10.1371/journal.pone.0079916
  • Peer Reviewed
• [Presentation] Epidemiology Of Influenza Infection Among Pregnant Women And Children Under 6 Months In Mongolia, 2013/14 and 2014/15 season: A Prospective Cohort Study (2015)
  • Author(s): Chaw, L.
  • Organizer: 1st The International Meeting on Respiratory Pathogens (IMRP) 2015
  • Place of Presentation: Singapore
  • Year and Date: 2015-09-02
  • Int'l Joint Research
• [Presentation] Epidemiology Of Influenza Infection Among Pregnant Women And Children Under 6 Months In Mongolia, 2013/14 Season: A Prospective Cohort Study (2014)
  • Author(s): Chaw Liling
  • Organizer: Third ISIRV-Antiviral Group Conference ("Influenza and Other Respiratory Virus Infections: Advances in Clinical Management")
  • Place of Presentation: 京王プラザホテル（東京）
  • Year and Date: 2014-06-04 – 2014-06-06
• [Presentation] Evidence gaps for informing policy development: burden of disease in Asia Pacific region. (2012)
  • Author(s): Oshitani H
  • Organizer: The First Asia Pacific Influenza Summit
  • Place of Presentation: Bangkok, Thailand
  • Invited
• [Presentation] Influenza surveillance in resource poor countries. (2012)
  • Author(s): Oshitani H
  • Organizer: An ISIRV International Conference on Seasonal and Pandemic Influenza: Incidence, Severity and Impact 2012
  • Place of Presentation: Munich, Germany
  • Invited
• [Presentation] Influenza disease and epidemiology (2012)
  • Author(s): Oshitani H
  • Organizer: The First Meeting on Seasonal Influenza Vaccines in Western Pacific Region
  • Place of Presentation: Manila, the Philippines
  • Invited
• [Remarks] 東北大学大学院医学系研究科・微生物学分野
  • URL: http://www.virology.med.tohoku.ac.jp/
• [Remarks] 東北大学医学系研究科 病理病態学講座 微生物学分野
  • URL: http://www.virology.med.tohoku.ac.jp/