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Transmission dynamics and evolution of influenza viruses in Asia

Research Project

Project/Area Number 24249041
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionTohoku University

Principal Investigator

Oshitani Hitoshi  東北大学, 医学(系)研究科(研究院), 教授 (80419994)

Co-Investigator(Kenkyū-buntansha) KAMIGAKI Taro  東北大学, 大学院医学系研究科, 助教 (80451524)
SUZUKI Akira  東北大学, 大学院医学系研究科, 助教 (20443989)
Research Collaborator SAITO Mariko (OBATA Mariko)  
OKAMOTO Michiko  
SAITO Mayuko  
TAMAKI Raita  
FURUSE Yuki  
NUKIWA Nao  
KHANDAKER Irona  
OKADA Takashi  
ODAGIRI Takashi  
IMAGAWA Toshifumi  
MIMURA Satoshi  
IMAMURA Tadatsugu  
KOSAI Hisato  
CHAW Liling  
Liu XIAOFANG  
Ngako Kadji Francois Marie  
OHNO Ayumu  
OTOMARU Hisano  
TOHMA Kentaro  
OHTANI Kanako  
Huo Xiang  
TAKAHASHI Yoshihiro  
FUJI Naoko  
MATSUZAKI Yoko  
HONGO Seiji  
Lupisan S.  フィリピン国RITM
Tandoc A.  フィリピン国RITM
Tallo V.  フィリピン国RITM
Tan A.  フィリピン国RITM
Alday P.  フィリピン国RITM
Nymadawa P.  モンゴル国 National Influenza Center及びNational Centre of Communicable Diseases
Nyamaa G.  モンゴル国 National Influenza Center及びNational Centre of Communicable Diseases
Burmaa A.  モンゴル国 National Influenza Center及びNational Centre of Communicable Diseases
Darmaa B.  モンゴル国 National Influenza Center及びNational Centre of Communicable Diseases
Bayasgalan N.  モンゴル国 National Influenza Center及びNational Centre of Communicable Diseases
Od I.  モンゴル国 National Influenza Center及びNational Centre of Communicable Diseases
Tsatsral S.  モンゴル国 National Influenza Center及びNational Centre of Communicable Diseases
Maitsetseg C.  モンゴル国 National Influenza Center及びNational Centre of Communicable Diseases
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥39,390,000 (Direct Cost: ¥30,300,000、Indirect Cost: ¥9,090,000)
Fiscal Year 2015: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2014: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Keywordsインフルエンザ / トランスミッション / モンゴル / フィリピン / ウイルス / 疫学 / アジア / 伝播
Outline of Final Research Achievements

Transmission dynamics of influenza viruses were analyzed in study sites in three countries; Philippines, Mongolia and Japan. Enhanced surveillance was conducted in Baguio City and Tacloban City in the Philippines and Odate City of Akita Prefecture in Japan, while the community-based cohort study was conducted in Baganuur District of Ulaanbataar City in Mongolia. Through these studies some important epidemiological findings have been obtained, which include; 1) significant role of children in transmission of influenza viruses, 2) transmission and maintenance mechanism of influenza viruses in the Philippines, which is located in tropical area, 3) low incidence of influenza in infants and pregnant women in Mongolia.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (22 results)

All 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (2 results) Journal Article (13 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 12 results,  Open Access: 10 results,  Acknowledgement Compliant: 6 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Remarks (2 results)

  • [Int'l Joint Research] National Center of Communicable Diseases/Monglian Academy of Medical Sciences(モンゴル)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Research Institute for Tropical Medicine(フィリピン)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Burden of Influenza and Respiratory Syncytial Virus Infection in Pregnant Women and Infants Under 6 Months in Mongolia: A Prospective Cohort Study.2016

    • Author(s)
      Chaw L, Kamigaki T, Burmaa A, Urtnasan C, Od I, Nyamaa G, Nymadawa P, Oshitani H.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 2 Pages: e0148421-e0148421

    • DOI

      10.1371/journal.pone.0148421

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Local persistence and global dissemination play a significant role in the circulation of influenza B viruses in Leyte Island, Philippines.2016

    • Author(s)
      Furuse Y, Odagiri T, Tamaki R, Kamigaki T, Otomaru H, Opinion J, Santo A, Dolina-Lacaba D, Daya E, Okamoto M, Saito-Obata M, Inobaya M, Tan A, Tallo V, Lupisan S, Suzuki A, Oshitani H.
    • Journal Title

      Virology

      Volume: 492 Pages: 21-24

    • DOI

      10.1016/j.virol.2016.02.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influenza and other respiratory viruses detected by influenza-like illness surveillance in Leyte Island, the Philippines, 2010-20132015

    • Author(s)
      Otomaru H, Kamigaki T, Tamaki R, Opinion J, Santo A, Daya E, Okamoto M, Saito M, Tallo V, Lupisan S, Suzuki A, Oshitani H
    • Journal Title

      PLoS One

      Volume: - Issue: 4 Pages: e0123755-e0123755

    • DOI

      10.1371/journal.pone.0123755

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Role of Preschool and Primary School Children in Epidemics of Influenza A in a Local Community in Japan during Two Consecutive Seasons with A(H3N2) as a Predominant Subtype.2015

    • Author(s)
      Mimura S, Kamigaki T, Takahashi Y, Umenai T, Kudou M, Oshitani H.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 5 Pages: e0125642-e0125642

    • DOI

      10.1371/journal.pone.0125642

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Analysis of influenza transmission in the households of primary and junior high school students during the 2012-13 influenza season in Odate, Japan.2015

    • Author(s)
      Kamigaki T, Mimura S, Takahashi Y, Oshitani H.
    • Journal Title

      BMC Infect Dis

      Volume: 23 Issue: 1 Pages: 282-282

    • DOI

      10.1186/s12879-015-1007-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular Epidemiology of the Human Rhinovirus Infection in Mongolia during 2008–20132015

    • Author(s)
      Tsatsral S, Xiang Z, Fuji N, Maitsetseg C, Khulan J, Oshitani H, Wang J, Nymadawa P.
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 68 Issue: 4 Pages: 280-287

    • DOI

      10.7883/yoken.JJID.2014.090

    • NAID

      130005088807

    • ISSN
      1344-6304, 1884-2836
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isolation and characterization of influenza C viruses in the Philippines and Japan2015

    • Author(s)
      Odagiri T, Matsuzaki Y, Okamoto M, Suzuki A, Saito M, Tamaki R, Lupisan SP, Sombrero LT, Hongo S, Oshitani H.
    • Journal Title

      J Clin Microbiol.

      Volume: 53 Issue: 3 Pages: 847-858

    • DOI

      10.1128/jcm.02628-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Role of preschool and primary school children in epidemics of influenza A in a local community in Japan during two consecutive seasons with A(H3N2) as a predominant subtype2015

    • Author(s)
      Mimura S, Kamigaki T, Takahashi Y, Umenai T, Kudou M, Oshitani H
    • Journal Title

      PLoS One

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] School closures during the 2009 influenza pandemic: national and local experiences.2014

    • Author(s)
      Cauchemez S, Van Kerkhove MD, Archer BN, Cetron M, Cowling BJ, Grove P, Hunt D, Kojouharova M, Kon P, Ungchusak K, Oshitani H, Pugliese A, Rizzo C, Saour G, Sunagawa T, Uzicanin A, Wachtel C, Weisfuse I, Yu H, Nicoll A.
    • Journal Title

      BMC Infect Dis.

      Volume: 14 Issue: 1 Pages: 1-1

    • DOI

      10.1186/1471-2334-14-207

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epidemiology and impact of influenza in Mongolia, 2007-20122014

    • Author(s)
      Burmaa A, Kamigaki T, Darmaa B, Nymadawa P, Oshitani H.
    • Journal Title

      Influenza Other Respir Viruses.

      Volume: 8 Pages: 530-537

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of medical consultation interval between the symptom onset and consultation observed in multiple medical facilities in Odate city, Japan, 2011-2013 seasons2014

    • Author(s)
      Huo X, Kamigaki T, Mimura S, Takahashi Y, Oshitani H
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: In press Issue: 6 Pages: 370-374

    • DOI

      10.1016/j.jiac.2014.02.005

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Estimating influenza outpatients' and inpatients' incidences from 2009 to 2011 in a tropical urban setting in the Philippines2014

    • Author(s)
      Tallo VL, Kamigaki T, Tan AG, Pamaran RR, Alday PP, Mercado ES, Javier JB, Oshitani H, Olveda RM
    • Journal Title

      Influenza Other Respir Viruses

      Volume: 8 Issue: 2 Pages: 159-168

    • DOI

      10.1111/irv.12223

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidemiological characterization of influenza A(H1N1)pdm09 cases from 2009 to 2010 in Baguio City, the Philippines2013

    • Author(s)
      Pamaran RR, Kamigaki T, Hewe TT, Flores KM, Mercado ES, Alday PP, Tan AG, Oshitani H, Olveda RM, Tallo VL
    • Journal Title

      PLoS One

      Volume: 8 Issue: 11 Pages: e79916-e79916

    • DOI

      10.1371/journal.pone.0079916

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Epidemiology Of Influenza Infection Among Pregnant Women And Children Under 6 Months In Mongolia, 2013/14 and 2014/15 season: A Prospective Cohort Study2015

    • Author(s)
      Chaw, L.
    • Organizer
      1st The International Meeting on Respiratory Pathogens (IMRP) 2015
    • Place of Presentation
      Singapore
    • Year and Date
      2015-09-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Epidemiology Of Influenza Infection Among Pregnant Women And Children Under 6 Months In Mongolia, 2013/14 Season: A Prospective Cohort Study2014

    • Author(s)
      Chaw Liling
    • Organizer
      Third ISIRV-Antiviral Group Conference ("Influenza and Other Respiratory Virus Infections: Advances in Clinical Management")
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2014-06-04 – 2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Evidence gaps for informing policy development: burden of disease in Asia Pacific region.2012

    • Author(s)
      Oshitani H
    • Organizer
      The First Asia Pacific Influenza Summit
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Influenza surveillance in resource poor countries.2012

    • Author(s)
      Oshitani H
    • Organizer
      An ISIRV International Conference on Seasonal and Pandemic Influenza: Incidence, Severity and Impact 2012
    • Place of Presentation
      Munich, Germany
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Influenza disease and epidemiology2012

    • Author(s)
      Oshitani H
    • Organizer
      The First Meeting on Seasonal Influenza Vaccines in Western Pacific Region
    • Place of Presentation
      Manila, the Philippines
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks] 東北大学大学院医学系研究科・微生物学分野

    • URL

      http://www.virology.med.tohoku.ac.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東北大学医学系研究科 病理病態学講座 微生物学分野

    • URL

      http://www.virology.med.tohoku.ac.jp/

    • Related Report
      2012 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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