A prospective cohort study on factors affecting quality of life and functioning of health among the elderly living in a community

• Project/Area Number: 24249043
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Nara Medical University
• Principal Investigator: KURUMATANI Norio 奈良県立医科大学, 医学部, 教授 (10124877)
• Co-Investigator(Kenkyū-buntansha): OKAMOTO Nozomi 奈良県立医科大学, 医学部, 講師 (70364057) ; KIMURA Hiroshi 奈良県立医科大学, 医学部, 教授 (20195374) ; OGATA Nahoko 奈良県立医科大学, 医学部, 教授 (60204062) ; SAEKI Keigo 奈良県立医科大学, 医学部, 講師 (60364056)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000); Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2012: ¥31,720,000 (Direct Cost: ¥24,400,000、Indirect Cost: ¥7,320,000)
• Keywords: コホート研究 / 高齢者 / QOL / 生活機能 / 健康関連QOL

Outline of Final Research Achievements

This was a prospective cohort study which aimed to detect risk factors and prospective factors of cognitive impairment, depression, hearing impairment, swallowing problems, dysuria, chronic obstructive pulmonary disease, and eye diseases, which were likely to induce a decline in higher-level functional capacity and quality of life in the old age. The subjects were 4427 community-dwelling independent elderly people. We performed a follow-up examination in the fifth year. The results of our study showed that tooth loss (a risk factor of mild cognitive impairment and swallowing problems), metabolic syndrome (a risk factor of depression), presence of urination symptom (a risk factor of nocturia), and nonparticipation in community activities were associated with a decline in higher-level functional capacity and QOL.

Research Products

• [Journal Article] Association between tooth loss and the development of mild memory impairment in the elderly: the Fujiwara-kyo study. (2015)
  • Author(s): Okamoto N, Morikawa M, Tomioka K, Yanagi M, Amano N, Kurumatanai N.
  • Journal Title: J Alzheimers Dis Volume: 44 Pages: 777-786
  • DOI: 10.3233/jad-141665
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Trabecular bone score may improve FRAX prediction accuracy for major osteoporotic fractures in elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in men (FORMEN) Study. (2015)
  • Author(s): Iki M, Fujita Y, Tamaki J, Kouda K, Yura A, Sato Y, Moon JS, Winzenrieth R, Okamoto N, Kurumatani N.
  • Journal Title: Osteoporos Int. Volume: 印刷中
  • DOI: 10.1007/s00198-015-3092-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Greater milk intake is associated with lower bone turnover, higher bone density, and higher bone microarchitecture index in a population of elderly Japanese men with relatively low dietary calcium intake: Fujiwara-kyo Osteoporosis Risk in men (FORMEN) Study. (2015)
  • Author(s): Sato Y, Iki M, Fujita Y, Tamaki J, Kouda K, Yura A, Moon JS, Winzenrieth R, Iwaki H, Ishizuka R, Amano N, Tomioka K, Okamoto N, Kurumatani N.
  • Journal Title: Osteoporos Int. Volume: 印刷中
  • DOI: 10.1007/s00198-015-3032-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Walking Speed Associated with Self-Perceived Hearing Handicap in the High-Functioning Elderly: the Fujiwara-kyo Study. (2015)
  • Author(s): Tomioka K, Harano A, Hazaki K, Morikawa M, Iwamoto J, Saeki K, Okamoto N, Kurumatani N.
  • Journal Title: Geriatr Gerontol Int. Volume: 印刷中 Pages: 745-754
  • DOI: 10.1111/ggi.12344
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Health-related Quality of Life (HRQOL) Decreases Independently of Chronic Conditions and Geriatric Syndromes in Older Adults With Diabetes: The Fujiwara-kyo Study (2014)
  • Author(s): Nezu S, Okamoto N, Morikawa M, Saeki K, Obayashi K, Tomioka K, Komatsu M, Iwamoto J, Kurumatani N.
  • Journal Title: Journal of Epidemiology Volume: 24 Issue: 4 Pages: 259-266
  • DOI: 10.2188/jea.je20130131 10.2188/jea.JE20130131
  • NAID: 130004449406
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 健常高齢者とアルツハイマー型認知症患者における樹木画特徴の比較：冠状樹冠に注目して (2014)
  • Author(s): 谷村昌美、木内邦明、森川将行、岡本希、車谷典男、岸本年史、佐藤豪.
  • Journal Title: 最新精神医学 Volume: 19 Pages: 235-243
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Renal function and bone mineral density in community-dwelling elderly Japanese men: The Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study. (2013)
  • Author(s): Fujita Y, Iki M, Tamaki J, Kouda K, Yura A, Kadowaki E, Sato Y, Moon JS, Tomioka K, Okamoto N, Kurumatani N.
  • Journal Title: Bone Volume: 56 Pages: 61-66
  • DOI: 10.1016/j.bone.2013.05.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Development of the Japanese 15D Instrument of Health-Relataed Quality of Life: Verification of Reliability and Validity among Elderly People (2013)
  • Author(s): Nozomi Okamoto
  • Journal Title: PLoS One Volume: 8
  • DOI: 10.1371/journal.pone.0061721
  • Peer Reviewed
• [Journal Article] Association between depressive symptoms and metabolic syndrome in Japanese community-dwelling older people: a cross-sectional analysis from the baseline results of the Fujiwara-kyo prospective cohort study. (2013)
  • Author(s): Morikawa M, Okamoto N, Kiuchi K, Tomioka K, Iwamoto J, Harano A, Saeki K, Fukusumi M, Hashimoto K, Amano N, Hazaki K, Yanagi M, Iki M, Yamada F, Kishimoto T, Kurumatani N.
  • Journal Title: Int J Geriatr Psychiatry Volume: 28 Pages: 1251-1259
  • DOI: 10.1002/gps.3950
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ―大規模コホート研究（藤原京スタディ）ベースライン健診結果― (2013)
  • Author(s): 小松雅代，根津智子，冨岡公子，羽崎完，原納明博，森川将行，高木正博，山田全啓，松本 善孝，岩本淳子，石塚理香，佐伯圭吾，岡本希，車谷典男
  • Journal Title: 日本衛生学雑誌 Volume: 68 Pages: 22-32
  • Peer Reviewed
• [Journal Article] A screening model for low bone mass in elderly Japanese men using quantitative ultrasound measurements: Fujiwara-Kyo Study. (2012)
  • Author(s): Minematsu A, Hazaki K, Harano A, Iki M, Fujita Y, Okamoto N, Kurumatani N.
  • Journal Title: J Clin Densitom Volume: 15 Pages: 343-350
  • DOI: 10.1016/j.jocd.2012.02.001
  • Peer Reviewed
• [Journal Article] Risk factors for new-onset overactive bladder in older subjects: results of the Fujiwara-kyo study. (2012)
  • Author(s): Hirayama A, Torimoto K, Mastusita C, Okamoto N, Morikawa M, Tanaka N, Fujimoto K, Yoshida K, Hirao Y, Kurumatani N.
  • Journal Title: Urology Volume: 80 Pages: 71-76
  • Peer Reviewed
• [Journal Article] Relationship between swallowing problems and tooth loss in community-dwelling independent elderly adults: the Fujiwara-kyo study. (2012)
  • Author(s): Okamoto N, Tomioka K, Saeki K, Iwamoto J, Morikawa M, Harano A, Kurumatani N.
  • Journal Title: J Am Geriatr Soc Volume: 60 Pages: 849-853
  • Peer Reviewed
• [Presentation] Incident clinical fracture was associated with increased risk of death after adjustment for frailty indices in elderly Japanese men: a cohort study (2015)
  • Author(s): Masayuki Iki , Yuki Fujita , Junko Tamaki , Katsuyasu Kouda , Akiko Yura , Yuho Sato , Jong-Seong Moon , Akihiro Harano , Kan Hazaki , Etsuko Kajita , Masami Hamada , Kiyomi Arai , Kimiko Tomioka , Nozomi Okamoto , Norio Kurumatani and Fujiwara-kyo Study Group
  • Organizer: World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases
  • Place of Presentation: Italy, Milan
  • Year and Date: 2015-03-26 – 2015-03-29
• [Presentation] Association between tooth loss and memory impairment in the elderly: the Fujiwara-kyo study. (2014)
  • Author(s): Nozomi Okamoto, Masayuki Morikawa, Kimiko Tomioka, Motokazu Yanagi, Nobuko Amano, Noriko Kurumatnai.
  • Organizer: WPA Section on Epidemiology and Public Health 2014 Meeting
  • Place of Presentation: Nara Prefectural New Public Hall
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] Trabecular Bone Score Improves Prediction accuracy of FRAX for Major Osteoporotic Fractures in Elderly Japanese Men: The Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Cohort Study (2014)
  • Author(s): Iki, Masayuki1; Fujita, Yuki1; Tamaki, Junko2; Sato, Yuho3; Winzenrieth, Renaud4; Kouda, Katuyasu1; Yura, Akiko1; Moon, Jong Seong5; Okamoto, Nozomi6; Kurumatani, Norio.
  • Organizer: 2014 ASBMR Annual Meeting
  • Place of Presentation: Houston, Texas, USA
  • Year and Date: 2014-09-12 – 2014-09-15
• [Presentation] 高齢者の眼疾患と視力の関連（大規模疫学研究：藤原京Study） (2014)
  • Author(s): 宮田季美恵、西智、大林賢史、佐伯圭吾、岡本希、松浦豊明、竹谷太、峯正志、岡本全弘、長谷川泰司、車谷典男、緒方奈保子
  • Organizer: 第118回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] 高齢者の視機能と認知機能―大規模疫学調査における眼科検診（藤原京アイスタディ） (2014)
  • Author(s): 峯正志、宮田季美恵、大林賢史、佐伯圭吾、岡本希、西智、森川将行、車谷典男、緒方奈保子
  • Organizer: 第118回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] 藤原京スタディにおける高齢一般住民における呼吸機能の検討 (2014)
  • Author(s): 山本佳史，吉川雅則，友田恒一，熊本牧子，藤田幸男，児山紀子，山内基雄，岡本希，車谷 典男，木村弘
  • Organizer: 第111回日本内科学会講演会
  • Place of Presentation: 東京
• [Presentation] 藤原京スタディにおける高齢一般住民のCOPD有病率とその実態 (2014)
  • Author(s): 山本佳史，吉川雅則，友田恒一，熊本牧子，藤田幸男，児山紀子，山内基雄，岡本希，車谷 典男，木村弘
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪
• [Presentation] 地域在住高齢者の5年後の認知機能低下の要因（認知機能別比較）：藤原京スタディ (2013)
  • Author(s): 森川将行、岡本 希、冨岡公子、佐伯圭吾、大林賢史、原納明博、天野信子、羽崎 完、岩本淳子、柳 元和、伊木雅之、車谷典男
  • Organizer: 第７２回日本公衆衛生学会総会
  • Place of Presentation: 三重
• [Presentation] 高齢者の認知機能と料理摂取頻度との関連について 藤原京スタディから (2013)
  • Author(s): 柳 元和, 天野 信子, 森川 将行, 岡本 希, 車谷 典男, 冨岡 公子, 佐伯 圭吾, 岩本 淳子, 原納 明博, 羽崎 完
  • Organizer: 第７２回日本公衆衛生学会総会
  • Place of Presentation: 三重
• [Presentation] 地域在住高齢者における歯牙喪失と嚥下障害との関連：藤原京スタディ (2013)
  • Author(s): 岡本希, 冨岡公子, 佐伯圭吾, 大林賢史, 天野信子, 柳元和, 森川将行, 車谷典男
  • Organizer: 第７２回日本公衆衛生学会総会
  • Place of Presentation: 三重
• [Presentation] Tooth Loss and Mild Memory Impairment in the Elderly: The Fujiwara-kyo study (2013)
  • Author(s): Nozomi Okamoto, Masayuki Morikawa, Kimiko Tomioka , Kenji Obayashi, Keigo Saeki , Norio Kurumatani
  • Organizer: 10th Asian Pacific Society of Periodontology
  • Place of Presentation: Nara, Japan
• [Presentation] 健常高齢者における身体機能の変化と運動能力および住環境との関係 －藤原京スタディ追跡調査結果による後向き分析－ (2013)
  • Author(s): 羽崎 完，峯松 亮，原納明博，岡本 希，車谷典男
  • Organizer: 第48回日本理学療法学術大会
  • Place of Presentation: 名古屋
• [Presentation] 高齢者大規模疫学調査 における眼科健診 (藤原京 Eye Study) (2013)
  • Author(s): 宮田季美恵、大林賢史、佐伯圭吾、岡本希、松浦豊明、西智、岡本全弘、小林武史、長谷川泰司、車谷典男、緒方奈保子
  • Organizer: 第117回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] 高齢者の白内障が視力と独立して視機能関連QOL 低下に 及ぼす影響（藤原京Eye Study） (2013)
  • Author(s): 宮田季美恵、佐伯圭吾、大林賢史、岡本希、長谷川泰司、丸山清子、竹谷太、松浦豊明、車谷典男、緒方奈保子
  • Organizer: 第67回日本臨床眼科学会総会
  • Place of Presentation: 横浜
• [Presentation] 地域在住高齢者の主観的認知機能障害に影響する要因：藤原京スタディ (2012)
  • Author(s): 森川将行、岡本希、岩本淳子、冨岡公子、原納明博、佐伯圭吾、天野信子、羽崎 完、柳 元和、伊木雅之、車谷典男
  • Organizer: 第７１回日本公衆衛生学会総会
  • Place of Presentation: 山口
• [Presentation] 独歩可能な高齢者の骨折発生の実態と医療機関調査の有用性～QOLと生活機能に関する高齢者コホート研究「藤原京スタディ」より～ (2012)
  • Author(s): 原納明博、清水豊信、車谷典男、岡本希、冨岡公子、伊木雅之、羽崎完、仲川喜之、田中康仁
  • Organizer: 第25回日本臨床整形外科学会学術集会
  • Place of Presentation: 神戸
• [Presentation] 高齢男性の新規骨折は生命予後を悪化させる：藤原京スタディ男性 (2012)
  • Author(s): 伊木雅之、藤田 裕規、玉置 淳子、甲田勝康、由良晶子、門脇英子、佐藤裕保、文鐘聲、原納明博、羽崎完、岡本希、車谷典男
  • Organizer: 第７１回日本公衆衛生学会総会
  • Place of Presentation: 山口
• [Presentation] INCIDENT CLINICAL FRACTURE INCREASES THE RISK OF MORTALITY IN COMMUNITY-DWELLING ELDERLY MEN: FUJIWARA-KYO OSTEOPOROSIS RISK IN MEN (FORMEN) STUDY (2012)
  • Author(s): Iki M, Fujita Y, Tamaki J, Kouda K, Yura A, Kadowaki E, Sato Y, Moon J.S, Harano A, Hazaki K, Okamoto N, Kurumatani N.
  • Organizer: 3rd Asia-Pacific Osteoporosis Meeting
  • Place of Presentation: Kuala Lumpur
• [Remarks] 奈良県立医科大学地域健康医学教室
  • URL: http://www.naramed-u.ac.jp/~che/
• [Remarks] 奈良県立医科大学地域健康医学教室
  • URL: http://www.naramed-u.ac.jp/~che/