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Identification of human bone marrow niche to support HSCs

Research Project

Project/Area Number 24249056
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionThe University of Tokyo

Principal Investigator

NAKAUCHI Hiromitsu  東京大学, 医科学研究所, 教授 (40175485)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥44,460,000 (Direct Cost: ¥34,200,000、Indirect Cost: ¥10,260,000)
Fiscal Year 2014: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2013: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2012: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Keywords骨髄ニッチ / TGF-beta / 休眠状態
Outline of Final Research Achievements

This project describes identification of human bone marrow niche to support HSCs. We hypothesized that identification of BM niche leads us to manipulate the function of human HSPCs in vivo and in vitro. Given that TGF-beta induces human HSPC hibernation, we analyzed the area where TGF is activated. Our result clearly showed that GFAP+ cells activate TGF and induce hibernation of human HSPCs in mouse BM. These findings were confirmed by the fact that nerve denervation reduces the number of human HSPCs in human BM. Furthermore, We first report suggesting an association between neural and hematopoietic systems.In this paper, we first described an innovative strategy to generate large numbers of HSCs from pluripotent stem cells. More specifically, we established in vivo differentiation system generating fully functional HSCs from mouse induced pluripotent stem cells. Using this system, we also succeeded in generating human HSCs from human iPSCs.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report

Research Products

(69 results)

All 2015 2014 2013 2012 Other

All Journal Article Presentation Book Patent(Industrial Property Rights)

  • [Journal Article] Effect of donor chimerism to reduce the level of glycosaminoglycans following bone marrow transplantation in a murine model of mucopolysaccharidosis type II2015

    • Author(s)
      Yokoi K, Akiyama K, Kaneshiro E, Higuchi T, Shimada Y, Kobayashi H, Akiyama M, Otsu M, Nakauchi H, Ohashi T, Ida H
    • Journal Title

      J Inherit Metab Dis

      Volume: 38 Pages: 333-340

    • DOI

      10.1007/s10545-014-9800-x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Screening of Drugs to Treat 8p11 Myeloproliferative Syndrome Using Patient-Derived Induced Pluripotent Stem Cells with Fusion Gene CEP110-FGFR1.2015

    • Author(s)
      Yamamoto S, Otsu M, Matsuzaka E, Konishi C, Takagi H, Hanada S, Mochizuki S, Nakauchi H, Imai K, Tsuji K, Ebihara Y
    • Journal Title

      PloS one

      Volume: 10

    • DOI

      10.1371/journal.pone.0120841

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating cells contribute to cardiomyocyte regeneration after injury2015

    • Author(s)
      Wu JM, Hsueh YC, Ch'ang HJ, Luo CY, Wu LW, Nakauchi H, Hsieh PC
    • Journal Title

      Circ Res

      Volume: 116 Pages: 633-41

    • DOI

      10.1161/circresaha.116.304564

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking2015

    • Author(s)
      A Sato, C Nishida, K Sato-Kusubata, M Ishihara, Y Tashiro, I Gritli, H Shimazu, S Munakata, H Yagita, K Okumura, Y Tsuda, Y Okada, A Tojo, H Nakauchi, S Takahashi, B Heissig and K Hattori
    • Journal Title

      Leukemia

      Volume: 29 Pages: 145-156

    • DOI

      10.1038/leu.2014.151

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effective treatment against severe graft-versus-host disease with allele-specific anti-HLA monoclonal antibody in a humanized mouse model.2015

    • Author(s)
      Nakauchi Y, Yamazaki S, Napier SC, Usui J, Ota Y, Takahashi S, Watanabe N, Nakauchi H
    • Journal Title

      Exp Hematol

      Volume: 43 Pages: 79-88

    • DOI

      10.1016/j.exphem.2014.10.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Quantification of adult T-cell leukemia/lymphoma cells using simple four-color flow cytometry.2015

    • Author(s)
      Ishigaki T, Zaike Y, Nojima M, Kobayashi S, Ohno N, Uchimaru K, Tojo A, Nakauchi H, Watanabe N
    • Journal Title

      Clin Chem Lab Med

      Volume: 53(1) Pages: 85-93

    • DOI

      10.1515/cclm-2014-0183

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T cell-restricted T-bet overexpression induces aberrant hematopoiesis of myeloid cells and impairs function of lung macrophages in the lung.2015

    • Author(s)
      Iriguchi S, Kikuchi N, Kaneko S, Noguchi E, Morishima Y, Matsuyama M, Yoh K, Takahashi S, Nakauchi H, Ishii Y
    • Journal Title

      Blood

      Volume: 125 Pages: 370-382

    • DOI

      10.1182/blood-2014-05-575225

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bone marrow Schwann cells induce hematopoietic stem cell hibernation.2014

    • Author(s)
      Yamazaki S, Nakauchi H
    • Journal Title

      Int J Hematol

      Volume: 99 Pages: 695-698

    • DOI

      10.1007/s12185-014-1588-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Five-lineage clonal analysis of hematopoietic stem/progenitor cells2014

    • Author(s)
      Yamamoto R, Morita Y, Nakauchi H
    • Journal Title

      Methods in molecular biology

      Volume: 1185 Pages: 237-45

    • DOI

      10.1007/978-1-4939-1133-2_16

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired hematopoietic differentiation of RUNX1-mutated induced pluripotent stem cells derived from FPD/AML patients. Leukemia,2014

    • Author(s)
      Sakurai M, Kunimoto H, Watanabe N, Fukuchi Y, Yuasa S, Yamazaki S, Nishimura T, Sadahira K, Fukuda K, Okano H, Nakauchi H, Morita Y, Matsumura I, Kudo K, Ito E, Ebihara Y, Tsuji K, Harada Y, Harada H, Okamoto S, Nakajima H
    • Journal Title

      Leukemia.

      Volume: 28 Pages: 2344-2354

    • DOI

      10.1038/leu.2014.136

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Multicolor staining of globin subtypes reveals impaired globin switching during erythropoiesis in human pluripotent stem cells.2014

    • Author(s)
      Ochi K, Takayama N, Hirose S, Nakahata T, Nakauchi H, Eto K
    • Journal Title

      Stem Cells Transl Med.

      Volume: 3 Pages: 792-800

    • DOI

      10.5966/sctm.2013-0216

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells.2014

    • Author(s)
      Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita KI, Koike T, Harimoto KI, Dohda T, Watanabe A, Okita K, Takahashi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K.
    • Journal Title

      Cell Stem Cell

      Volume: 14 Pages: 535-48

    • DOI

      10.1016/j.stem.2014.01.011

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Tif1β-Hp1 system maintains transcriptional integrity of hematopoietic stem cells.2014

    • Author(s)
      Miyagi S, Koide S, Saraya A, Wendt GR, Oshima M, Konuma T, Yamazaki S, Mochizuki-Kashio M, Nakajima-Takagi Y, Wang C, Chiba T, Kitabayashi I, Nakauchi H, Iwama A.
    • Journal Title

      Stem cell reports

      Volume: 2 Pages: 145-52

    • DOI

      10.1016/j.stemcr.2013.12.008

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not tomyelodysplasia2014

    • Author(s)
      Matsunawa M, Yoshida K
    • Journal Title

      Leukemia.

      Volume: (Epub ahead of print) Pages: 1844-1850

    • DOI

      10.1038/leu.2014.73

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Stage-specific roles for Cxcr4 signaling in murine hematopoietic stem/progenitor cells in the process of bone marrow repopulation2014

    • Author(s)
      Lai CY, Yamazaki S, Okabe M, Suzuki S, Maeyama Y, Iimura Y, Onodera M, Kakuta S, Iwakura Y, Nojima M, Otsu M, Nakauchi H.
    • Journal Title

      Stem Cells

      Volume: - Pages: 1929-42

    • DOI

      10.1002/stem.1670

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies.2014

    • Author(s)
      Kazuki Y, Yakura Y, Abe S, Osaki M, Kajitani N, Kazuki K, Takehara S, Honma K, Suemori H, Yamazaki S, Sakuma T, Toki T, Shimizu R, Nakauchi H, Yamamoto T, Oshimura M
    • Journal Title

      Sci Rep

      Volume: 4 Pages: 6136-6136

    • DOI

      10.1038/srep06136

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice.2014

    • Author(s)
      Keiichi Ito, Satoshi Yamazaki, Ryo Yamamoto, Yoko Tajima, Ayaka Yanagida, Toshihiro Kobayashi, Megumi Kato-Itoh, Shigeru Kakuta, Yoichiro Iwakura, Hiromitsu Nakauchi, Akihide Kamiya,
    • Journal Title

      J Biol Chem.

      Volume: 289(43) Pages: 29892-298911

    • DOI

      10.1074/jbc.m114.580084

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clock gene Bmal1 is dispensable for intrinsic properties of murine hematopoietic stem cells2014

    • Author(s)
      Ieyasu A, Tajima Y, Shimba S, Nakauchi H, Yamazaki S
    • Journal Title

      Journal of negative results in biomedicine

      Volume: 13 Pages: 4-4

    • DOI

      10.1186/1477-5751-13-4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of induced pluripotent stem cells derived from primary and secondary myelofibrosis patient samples.2014

    • Author(s)
      Hosoi M, Kumano K, Taoka K, Arai S, Kataoka K, Ueda K, Kamikubo Y, Takayama N, Otsu M, Eto K, Nakauchi H, Kurokawa M
    • Journal Title

      Experimental Hematology

      Volume: (in press) Pages: 816-25

    • DOI

      10.1016/j.exphem.2014.03.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Chemical Probe That Labels Human Pluripotent Stem Cells.2014

    • Author(s)
      Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato S, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M
    • Journal Title

      Cell Rep

      Volume: 6 Pages: 1165-1174

    • DOI

      10.1016/j.celrep.2014.02.006

    • NAID

      120005466668

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The generation of induced pluripotent stem cells (iPSCs) from patients with infantile and late-onset types of Pompe disease and the effects of treatment with acid-α-glucosidase in Pompe's iPSCs.2014

    • Author(s)
      Higuchi T, Kawagoe S, Otsu M, Shimada Y, Kobayashi H, Hirayama R, Eto K, Ida H, Ohashi T, Nakauchi H, Eto Y
    • Journal Title

      Mol Genet Metab

      Volume: 112 Pages: 44-48

    • DOI

      10.1016/j.ymgme.2014.02.012

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nov/CCN regulates long term repopulation activity of murine hematopietic stem cells via integrin avb32014

    • Author(s)
      J. Ishihara, et al
    • Journal Title

      Int J Hematol

      Volume: (印刷中) Pages: 393-406

    • DOI

      10.1007/s12185-014-1534-x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Homeodomain transcription factor meis1 is a critical regulator of adult bone marrow hematopoiesis2014

    • Author(s)
      Ariki R, Morikawa S, Mabuchi Y, Suzuki S, Nakatake M, Yoshioka K, Hidano S, Nakauchi H, Matsuzaki Y, Nakamura T, Goitsuka R.
    • Journal Title

      PLOS ONE

      Volume: 9 Pages: 87646-87646

    • DOI

      10.1371/journal.pone.0087646

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enzyme augmentation therapy enhances the therapeutic efficacy of bone marrow transplantation in mucopolysaccharidosis type II mice.2014

    • Author(s)
      Akiyama K, Shimada Y, Higuchi T, Ohtsu M, Nakauchi H, Kobayashi H, Fukuda T, Ida H, Eto Y, Crawford BE, Brown JR, Ohashi T
    • Journal Title

      Mol Genet Metab.

      Volume: 111 Pages: 139-46

    • DOI

      10.1016/j.ymgme.2013.09.013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of Col2a1-EGFP-iPS cells for monitoring chondrogenic differentiation.2014

    • Author(s)
      Saito T, Yano F, Mori D, Ohba S, Hojo H, Otsu M, Eto K, Nakauchi H, Tanaka S, Chung UI, Kawaguchi H
    • Journal Title

      PLoS ONE

      Volume: 16;8(9)

    • DOI

      10.1371/journal.pone.0074137

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Derivation of Embryonic Stem Cell Lines from Parthenogenetically Developing Rat Blastocysts.2014

    • Author(s)
      Hirabayashi M, Goto T, Tamura C, Sanbo M, Hara H, Kato-Itoh M, Sato H, Kobayashi T, Nakaushi H, Hochi S.
    • Journal Title

      Stem Cell Dev.

      Volume: VOL.23 Pages: 107-114

    • DOI

      10.1089/scd.2013.0200

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Immortalization of Erythroblasts by c-MYC and BCL-XL Enables Large-Scale Erythrocyte Production from Human Pluripotent Stem Cells2013

    • Author(s)
      Hirose, S., N. Takayama, S. Nakamura, K. Nagasawa, K. Ochi, S. Hirata, S. Yamazaki, T. Yamaguchi, M. Otsu, S. Sano, N. Takahashi, A. Sawaguchi, M. Ito, T. Kato, H. Nakauchi, and K. Eto.
    • Journal Title

      Stem cell reports

      Volume: 1 Pages: 499-508

    • DOI

      10.1016/j.stemcr.2013.10.010

    • NAID

      120005350227

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Profiling of microRNA in human and mouse ES and iPS cells reveals overlapping but distinct microRNA expression patterns2013

    • Author(s)
      Razak SR, Ueno K, Takayama N, Nariai N, Nagasaki M, Saito R, Koso H, Lai CY, Murakami M, Tsuji K, Michiue T, Nakauchi H, Otsu M, Watanabe S.
    • Journal Title

      Plos One

      Volume: 8

    • DOI

      10.1371/journal.pone.0073532

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Top-down motif engineering of a cytokine receptor for directing ex vivo expansion of hematopoietic stem cells2013

    • Author(s)
      Saka K, Kawahara M, Teng J, Otsu M, Nakauchi H, Nagamune T.
    • Journal Title

      J Biotechnol

      Volume: 168 Pages: 659-65

    • DOI

      10.1016/j.jbiotec.2013.09.012

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Do pluripotent stem cells exist in adult mice as very small embryonic stem cells?2013

    • Author(s)
      Miyanishi M, Mori Y, Seita J, Chen JY, Karten S, Chan CK, Nakauchi H, Weissman IL.
    • Journal Title

      Stem Cell Reports.

      Volume: 1 Pages: 198-208

    • DOI

      10.1016/j.stemcr.2013.07.001

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells2013

    • Author(s)
      Yamamoto R, Morita Y, Ooehara J, Hamanaka S, Onodera M, Rudolph KL, Ema H, Nakauchi H.
    • Journal Title

      CELL

      Volume: 154 Pages: 1112-1126

    • DOI

      10.1016/j.cell.2013.08.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recurrent mutations in multiple components of the cohesin complex inmyeloid neoplasms2013

    • Author(s)
      Kon A, Yoshida K
    • Journal Title

      Nature Genetics

      Volume: 45 Pages: 1232-1237

    • DOI

      10.1038/ng.2731

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An in vitro expansion system for generation of human iPS cell-derived hepatic progenitor-like cells exhibiting a bipotent differentiation potential.2013

    • Author(s)
      Yanagida A, Ito K, Chikada H, Nakauchi H, Kamiya A.
    • Journal Title

      Plos One

      Volume: 8

    • DOI

      10.1371/journal.pone.0067541

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling2013

    • Author(s)
      Shinji Hirata, Naoya Takayama,Ryoko Jono-Ohnishi, Hiroshi Endo, Sou Nakamura, Takeaki Dohda, Masanori Nishi, Yuhei Hamazaki, Ei-ichi Ishii, Shin Kaneko, Makoto Otsu, Hiromitsu Nakauchi, Shinji Kunishima, and Koji Eto.
    • Journal Title

      The Journal of clinical investigation

      Volume: 123 Pages: 3802-14

    • DOI

      10.1172/jci64721

    • NAID

      120005312065

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell-derived megakaryocytes2013

    • Author(s)
      Nakagawa Y, Nakamura S, Nakajima M, Endo H, Dohda T, Takayama N, Nakauchi H, Arai F, Fukuda T, Eto K.
    • Journal Title

      Experimental Hematology

      Volume: 41 Pages: 742-748

    • DOI

      10.1016/j.exphem.2013.04.007

    • NAID

      120005312061

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation2013

    • Author(s)
      Suzuki N, Yamazaki S, Yamaguchi T, Okabe M, Masaki H, Takaki S, Otsu M, Nakauchi H.
    • Journal Title

      Mol Ther

      Volume: 21 Pages: 1424-1431

    • DOI

      10.1038/mt.2013.71

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of transgenic mouse line expressing Kusabira Orange throughout body, including erythrocytes, by random segregation of provirus method.2013

    • Author(s)
      Hamanaka S, Ooehara J, Morita Y, Ema H, Takahashi S, Miyawaki A, Otsu M, Yamaguchi T, Onodera M, Nakauchi H
    • Journal Title

      Biochemical and biophysical research communications

      Volume: i435(4) Pages: 586-591

    • DOI

      10.1016/j.bbrc.2013.05.017

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Sendai virus vectors and their potential applications in gene therapy and regenerative medicine.2013

    • Author(s)
      Keiki Kumano
    • Journal Title

      Curr Gene Ther.

      Volume: 119 Pages: 6234-42

    • DOI

      10.1182/blood-2011-07-367441

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stem cell therapy: an exercise in patience and prudence. Stem cell therapy: an exercise in patience and prudence.2013

    • Author(s)
      Lin HT, Otsu M, Nakauchi H.
    • Journal Title

      Biological sciences

      Volume: 5 Pages: 20110334-20110334

    • DOI

      10.1098/rstb.2011.0334

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Manipulation of hematopoietic stem cells for regenerative medicine2013

    • Author(s)
      Nakajima-Takagi Y, Osawa M, Oshima M, Takagi H, Miyagi S, Endoh M, Endo TA, Takayama N, Eto K, Toyoda T, Koseki H, Nakauchi H, Iwama A.
    • Journal Title

      Blood

      Volume: 121 Pages: 447-458

    • DOI

      10.1182/blood-2012-05-431403

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of rejuvenated antigen-specific T cells by pluripotency reprogramming and dedifferentiation.2013

    • Author(s)
      Nishimura T, Koseki H, Nakauchi H. 他
    • Journal Title

      Cell StemCell.

      Volume: 12 Pages: 114-126

    • DOI

      10.1016/j.stem.2012.11.002

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells2012

    • Author(s)
      Chiemi Nishida, Kaori Kusubata, Yoshihiko Tashiro, Ismael Gritli, Aki Sato, Makiko Ohki-Koizumi, Yohei Morita, Makoto Nagano, Takeharu Sakamoto, Naohiko Koshikawa, Takahiro Kuchimaru, Shinae Kizaka-Kondoh, Motoharu Seiki, Hiromitsu Nakauchi, Beate Heissig, and Koichi Hattori.
    • Journal Title

      Blood.

      Volume: 119 Pages: 5405-16

    • DOI

      10.1182/blood-2011-11-390849

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] nhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration viaproduction of angiocrine factors in mice2012

    • Author(s)
      Yoshihiko Tashiro, Chiemi Nishida, Kaori Sato-Kusubata, Makiko Ohki-Koizumi, Makoto Ishihara, Aki Sato, Ismael Gritli, Hiromitsu Komiyama, Yayoi Sato, Takashi Dan, Toshio Miyata, Ko Okumura, Yuichi Tomiki, Kazuhiro Sakamoto, Hiromitsu Nakauchi, Beate Heissig, and Koichi Hattori.
    • Journal Title

      blood

      Volume: 119 Pages: 6382-6393

    • DOI

      10.1182/blood-2011-12-399659

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.2012

    • Author(s)
      Nakamura S, Oshima M, Yuan J, Saray a A, Miyagi S, Konuma T, Yamazaki S, Osawa M, Nakauchi H, Koseki H, Iwama A.
    • Journal Title

      PLoS ONE

      Volume: 7(5)

    • DOI

      10.1371/journal.pone.0036209

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.2012

    • Author(s)
      Yamaguchi T, Hamanaka S, Kamiya A, Okabe M, Kawarai M, Wakiyama Y, Umino A, Hayama T, Sato H, Lee YS, Kato-Itoh M, Masaki H, Kobayashi T, Yamazaki S, Nakauchi H.
    • Journal Title

      PLoS One

      Volume: 7

    • DOI

      10.1371/journal.pone.0041007

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid T-cell chimerism switch and memory T-cell expansion are associated with pre-engraftment immune reaction early after cord blood transplantation.2012

    • Author(s)
      Matsuno N, Yamamoto H, Watanabe N, Uchida N, Ota H, Nishida A, Ikebe T, Ishiwata K, Nakano N, Tsuji M, Asano-Mori Y, Izutsu K, Masuoka K, Wake A, Yoneyama A, Nakauchi H, Taniguchi S.
    • Journal Title

      Br J Haematol

      Volume: 160 Pages: 255-8

    • DOI

      10.1111/bjh.12097

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Myeloid-biased hematopoiesis in aged mouse bone marrow2015

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      Japan-US Hematology conference
    • Place of Presentation
      Hawaii, U.S.
    • Year and Date
      2015-03-16 – 2015-03-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The Stem Cell Niche2015

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Ventura Beach Marriott, Ventura, CA. US
    • Year and Date
      2015-02-15 – 2015-02-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] In vivo generation of hematopoietic stem cells from iPSCs2014

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      JST-CIHR Epigenetics F2F Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2014-10-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Single cell transplantation and clonal analysis of hematopoietic stem cells: Exploring heterogeneity and hierarchy2014

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      Till&McCulloch Meetings
    • Place of Presentation
      Ottawa, Canada
    • Year and Date
      2014-10-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] "Novel non-stepwise early differentiation pathways of HSCs revealed by 5-lineage in vivo tracing"2013

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      Gordon Research Conference “Stem Cells & Cancer”
    • Place of Presentation
      Les Diablerets, Switzerland
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] In Vivo Clonal Analysis of Hematopoietic Stem Cells Unveils Novel Myeloid Bypass Differentiation Pathways.2013

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      2013 USA-Japan Science Conference
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] iPS technology and its future therapeutic potentials.2012

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      The 5th Dutch Society for Stem Cell Research Meeting (DSSCR)
    • Place of Presentation
      Amsterdam, Holland
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Isolation, Clonal Characterization and Hibernation of Hematopoietic Stem Cells.2012

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      Wellcome Trust Centre for Stem Cell Research, University of Cambridge
    • Place of Presentation
      Cambridge, England
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Generation of functional organs from pluripotent stem cells.2012

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      ISSCR 10th Annual Meeting
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Generation of functional organs from pluripotent stem cells.2012

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      Lecture Theatre, Department of Biochemistry, Cambridge Stem Cell Club
    • Place of Presentation
      Cambridge, England
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] iPS technology and its future therapeutic potentials.2012

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      The Sanger Institute
    • Place of Presentation
      Cambridge, England
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] iPS technology and its potential for future medicine.2012

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      University of Geneva Hospital
    • Place of Presentation
      Geneva, Switzerland
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Stem cell biology and its potentials for future medicine.2012

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      University of Zurich
    • Place of Presentation
      Zurich, Switzerland
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] iPS technology and its potential for future medicine.2012

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      The Babraham Institute
    • Place of Presentation
      Cambridge, England
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Stem Cell Niche and TGF-beta signaling.2012

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      EMBL Conference, Stem Cells in Cancer and Regenerative Medicine
    • Place of Presentation
      Edinburgh, England
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Hibernation of Hematopoietic Stem Cells in the Bone Marrow Niche.2012

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      The University of Edinburgh
    • Place of Presentation
      Edinburgh, England
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Glial cell regulation of hematopoietic stem cell hibernation in the bone marrow niche.2012

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      ESGCT/SFTCG Congress
    • Place of Presentation
      Versailles, France
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Rat-mouse interspecific chimeras for study of organogenesis and elucidation of xenogenic barrier.2012

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      Joint meeting of ISD and NIRM
    • Place of Presentation
      Amsterdam, Netherland
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Non-myelinating Schwann cells in the mouse bone marrow niche maintain hematopoietic stem cell hibernation through TGF-β signaling.2012

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      Cold Spring Harbor Asia Conferences
    • Place of Presentation
      Suzhou, China
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Exploring heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment

    • Author(s)
      中内啓光
    • Organizer
      日本分子生物学会シンポジウム
    • Place of Presentation
      兵庫
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 幹細胞研究と再生医療2013

    • Author(s)
      中内啓光(編集)
    • Total Pages
      238
    • Publisher
      南山堂
    • Related Report
      2013 Annual Research Report
  • [Book] 直伝!フローサイトメトリー2013

    • Author(s)
      中内啓光(監修)清田純(編集)
    • Total Pages
      278
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 造血幹細胞を減少させる組成物およびその製造法2014

    • Inventor(s)
      中内 啓光、山崎 聡、田矢 祐規
    • Industrial Property Rights Holder
      国立大学法人 東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-11-25
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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